Results 151 to 160 of about 2,349 (173)

Establishment of cocrystal cocktail grinding method for rational screening of pharmaceutical cocrystals

International Journal of Pharmaceutics, 2012
Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto, Shunichirou, Tsutsumi, Yukihiro, Ikeda   +2 more
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ChemInform Abstract: Pharmaceutical Cocrystals

ChemInform, 2011
AbstractReview: 98 refs.
Ning Qiao, Mingzhong Li, Walkiria Schlindwein, Nazneen Malek, Angela Davies, Gary Trappitt   +5 more
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Solubility Advantage of Pharmaceutical Cocrystals

Crystal Growth & Design, 2009
Pharmaceutical cocrystals can improve solubility, dissolution, and bioavailability of poorly water soluble drugs. However, true cocrystal solubility is not readily measured for highly soluble cocrystals because they can transform to the most stable drug form in solution.
David J. Good, Naír Rodríguez-Hornedo
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Impact of pharmaceutical cocrystals: the effects on drug pharmacokinetics

Expert Opinion on Drug Metabolism & Toxicology, 2014
Pharmaceutical cocrystallization has emerged in the past decade as a new strategy to enhance the clinical performance of orally administered drugs. A pharmaceutical cocrystal is a multi-component crystalline material in which the active pharmaceutical ingredient is in a stoichiometric ratio with a second compound that is generally a solid under ambient
Ning, Shan, Miranda L, Perry, David R, Weyna, Michael J, Zaworotko   +3 more
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Pharmaceutical cocrystals: along the path to improved medicines

Chemical Communications, 2016
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest from crystal engineers and pharmaceutical scientists in the past decade and are now an integral part of the preformulation stage of drug development.
Naga K, Duggirala, Miranda L, Perry, Örn, Almarsson, Michael J, Zaworotko   +3 more
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Cocrystal Systems of Pharmaceutical Interest: 2009

2011
As scientists become more aware of a substantial expansion in the scope of solid-state structural variations that can be obtained through the cocrystallization of several molecules in a single lattice structure, studies of the mixed molecular crystal systems known as cocrystals have mushroomed. Along these lines, workers have researched the assembly of
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Mass transport of pharmaceutical cocrystals

2018
<p>Cocrystals have two or more neutral components (drug and cocrystal former) in the same crystal lattice which are held together via non-covalent bonds. Since the presence of the cocrystal former alters the energy of the drug molecules and their physicochemical properties, the drug dissolution characteristics can be manipulated by ...
Hui Zu, Leonard R. MacGillivray, Dale Eric Wurster, Douglas R. Flanagan, Maureen D. Donovan, Geoff G.Z. Zhang, Lewis L. Stevens   +6 more
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Cocrystal Systems of Pharmaceutical Interest: 2007–2008

2010
Publisher Summary The chapter focuses on the literature published primarily during 2007 and 2008 regarding cocrystal systems that have a pharmaceutical interest. The literature cited in the chapter reviews primarily from the major physical, crystallographic, and pharmaceutical journals, and consequently the coverage cannot be represented as being ...
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Molecular cocrystals of pharmaceutical interest [PDF]

, 2015
Crystal form (cocrystals, polymorphs, salts, hydrates and solvates) assortment remains a scientific challenge that implicates practical issues in the pharmaceutical industry at the late stage of drug development of pharmaceutical formulations and in early stage of synthesis and isolation of an API in favorable defined crystalline form.
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Solution Stability of Pharmaceutical Cocrystals

Crystal Growth & Design, 2022
Amin Alvani, Ali Shayanfar
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