Results 61 to 70 of about 9,767 (219)
International Journal of Hepatology, 2018 Background and Aims. Both paracetamol (PA) and phenacetin (PH) are analgesic and antipyretic agents. Part of phenacetin therapeutic activity is attributed to its metabolism into paracetamol. Paracetamol causes direct hepatic oxidative stress damage.
Tahia H. Saleem +6 more
doaj +1 more source
Systemic Inflammation and Oxidative Stress Markers in Patients With Medication Overuse Headache
Brain and Behavior, Volume 15, Issue 10, October 2025.Patients with medication overuse headache (MOH) showed distinct inflammatory and oxidative stress profiles compared to healthy controls. Elevated values of lymphocyte to high‐density lipoprotein (HDL) ratio (LHR), monocyte to HDL ratio (MHR), and neutrophil to HDL ratio (NHR) were independently associated with MOH. ABSTRACT Background Recent scientific
Changling Li +11 more
wiley +1 more source
Microchip electrophoresis-electrochemical detection platform for analysis of drugs and their metabolites [PDF]
, 2015 U razdoblju ubrzanog rasta farmaceutske industrije razvoj postojećih analitičkih metoda je prespor i ne može zadovoljiti potrebe zahtjevnih metaboličkih analiza novih lijekova i novih kemijskih entiteta (kemikalija iz okoliša i kućanstva).
Lenić, Ines
core +1 more source
Treading the fine white line: cocaine trafficking [PDF]
, 2016 The illicit drug’s trade is a highly profitable business that grasps the interest of millions of people and equally affects millions of others. Cocaine is a highly addictive drug that plagues many countries.
McNicholl, S, O'Hagan, A
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Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.ABSTRACT Alzheimer's disease (AD) is the most prevalent cause of dementia, characterized by progressive cognitive decline and cerebral metabolic impairment. Yet, the therapeutic options for addressing the disease pathogenesis are limited. Here, we report an approach by targeting brain nucleoside homeostasis and energy metabolism to alleviate AD ...
Kuo‐Chen Wu +7 more
wiley +1 more source
Metabolism of six CYP probe substrates in fetal hepatocytes
ADMET and DMPK, 2016 Cytochrome P-450 (CYP) are the most common drug metabolizing enzymes and are abundantly expressed in liver apart from kidney, lungs, intestine, brain etc. Their expression levels change with physiological conditions and disease states.
Abdul Naveed Shaik +2 more
doaj +1 more source
Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 5, Page 433-438, September 2025.ABSTRACT Our aim was to investigate whether vatinoxan, a peripherally acting alpha2‐adrenoceptor antagonist, would affect the concentrations of medetomidine, midazolam, and fentanyl in the central nervous system after subcutaneous co‐administration. Twelve healthy male Wistar rats, aged between 13 and 15 weeks, were used in this study.
Juhana Honkavaara +5 more
wiley +1 more source
End-stage renal failure due to analgesic nephropathy, its changing pattern and cardiovascular mortality [PDF]
, 2017 The changing pattern of prevalence and age distribution of analgesic nephropathy as a cause of end-stage renal failure (ESRF) in patients on RRT was analysed using the EDTA-ERA Registry's files.
Brunner, F. P., Selwood, Neville H.
core
Advanced Science, Volume 12, Issue 32, August 28, 2025.The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye +16 more
wiley +1 more source
Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature [PDF]
, 2016 BACKGROUND: Information about drug-drug interactions (DDIs) supported by scientific evidence is crucial for establishing computational knowledge bases for applications like pharmacovigilance.
Li, Lang +6 more
core +1 more source