Deficits in medial prefrontal cortex parvalbumin expression and distraction-dependent memory in rats and mice in the sub-chronic phencyclidine model for schizophrenia [PDF]
Frontiers in Cellular NeuroscienceIntroductionCognitive impairments associated with schizophrenia (CIAS) include deficits in declarative memory. This is associated with an inability to maintain information in short-term memory when distracted, and increased sensitivity to proactive ...
Katie R. Landreth +9 more
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Nicotine’s Effects on Schizophrenia-like Symptoms in a Mice Model: Time Matters [PDF]
Brain SciencesTobacco consumption in schizophrenia (SCHZ) patients is highly prevalent. Data support the occurrence of sequential events during comorbidity establishment, and both smoking first, SCHZ second and SCHZ first, smoking second sequences have been proposed ...
Ana Carolina Dutra-Tavares +8 more
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Phencyclidine Disrupts the Auditory Steady State Response in Rats. [PDF]
PLoS ONE, 2015 The Auditory Steady-State Response (ASSR) in the electroencephalogram (EEG) is usually reduced in schizophrenia (SZ), particularly to 40 Hz stimulation.
Emma Leishman +7 more
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A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits [PDF]
Brain SciencesBackground/Objectives: Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of neurodevelopmental disorders is essential ...
Imane Mouffok +5 more
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Reassessment of amphetamine- and phencyclidine-induced locomotor hyperactivity as a model of psychosis-like behavior in rats [PDF]
Journal of Integrative Neuroscience, 2022 Locomotor hyperactivity induced by psychotomimetic drugs, such as amphetamine and phencyclidine, is widely used as an animal model of psychosis-like behaviour and is commonly attributed to an interaction with dopamine release and N-methyl-D-aspartate (
Snezana Kusljic +2 more
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Effects of Long-term antipsychotic treatment on enkephalin-immunoreactive neurons in rats perinatally treated with phencyclidine [PDF]
Medicinski Podmladak, 2023 Introduction: Schizophrenia is a chronic mental illness that affects 1% of the world's population. The phencyclidine animal model of schizophrenia is based on the glutamate theory of the development of schizophrenia.
Kompanijec Anja +2 more
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PLoS ONE, 2021 The first symptoms of schizophrenia (SCHZ) are usually observed during adolescence, a developmental period during which first exposure to psychoactive drugs also occurs.
Ana Carolina Dutra-Tavares +7 more
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Synthesis and characterization of phencyclidine and his derivatives [PDF]
Hemijska Industrija, 2010 Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best known representative drug from the compound class of arylcyclohexylamines. On an account of pharmacological activities it belongs to the family of drugs known as a dissociative anesthetics.
Ilić Nataša C. +3 more
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Frontiers in Cellular Neuroscience, 2023 N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP ...
Cristina Delgado-Sallent +9 more
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Cells, 2022 Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm in hippocampal slice
Michael Spedding +18 more
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