Deficits in medial prefrontal cortex parvalbumin expression and distraction-dependent memory in rats and mice in the sub-chronic phencyclidine model for schizophrenia [PDF]
Frontiers in Cellular NeuroscienceIntroductionCognitive impairments associated with schizophrenia (CIAS) include deficits in declarative memory. This is associated with an inability to maintain information in short-term memory when distracted, and increased sensitivity to proactive ...
Katie R. Landreth +9 more
doaj +4 more sources
PLoS ONE, 2021 The first symptoms of schizophrenia (SCHZ) are usually observed during adolescence, a developmental period during which first exposure to psychoactive drugs also occurs.
Ana Carolina Dutra-Tavares +7 more
doaj +2 more sources
Nicotine’s Effects on Schizophrenia-like Symptoms in a Mice Model: Time Matters [PDF]
Brain SciencesTobacco consumption in schizophrenia (SCHZ) patients is highly prevalent. Data support the occurrence of sequential events during comorbidity establishment, and both smoking first, SCHZ second and SCHZ first, smoking second sequences have been proposed ...
Ana Carolina Dutra-Tavares +8 more
doaj +2 more sources
Phencyclidine Disrupts the Auditory Steady State Response in Rats. [PDF]
PLoS ONE, 2015 The Auditory Steady-State Response (ASSR) in the electroencephalogram (EEG) is usually reduced in schizophrenia (SZ), particularly to 40 Hz stimulation.
Emma Leishman +7 more
doaj +2 more sources
The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. [PDF]
PLoS ONE, 2013 In this paper we determined the pharmacological profiles of novel ketamine and phencyclidine analogues currently used as 'designer drugs' and compared them to the parent substances via the resources of the National Institute of Mental Health Psychoactive
Bryan L Roth +6 more
doaj +2 more sources
A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits [PDF]
Brain SciencesBackground/Objectives: Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of neurodevelopmental disorders is essential ...
Imane Mouffok +5 more
doaj +2 more sources
Fatality Following Ingestion of Tetrahydrofuranylfentanyl, U-49900 and Methoxy-Phencyclidine [PDF]
Journal of Analytical Toxicology, 2017 Alex J. Krotulski +5 more
openalex +2 more sources
Phencyclidine Intoxication Case Series Study [PDF]
Journal of Medical Toxicology, 2014 Paul Dominici +5 more
openalex +2 more sources
Translational aspects of the novel object recognition task in rats abstinent following sub-chronic treatment with phencyclidine (PCP): effects of modafinil and relevance to cognitive deficits in schizophrenia? [PDF]
Frontiers in Psychiatry, 2010 Phencyclidine (PCP) induces a behavioural syndrome in rodents that bears remarkable similarities to some of the core symptoms observed in schizophrenic patients, among those cognitive deficits.
John P Redrobe +2 more
doaj +2 more sources
DFT and QTAIM insights into C<sub>20</sub> fullerene derivatives as advanced sensors for phencyclidine drug detection in clinical settings. [PDF]
Sci RepAlamri A, Alafnan A.
europepmc +3 more sources