Results 51 to 60 of about 30,643 (283)

Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine [PDF]

, 2006
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP) and ketamine can evoke psychotic symptoms in normal individuals and schizophrenic patients.
D. Hanisch, G. Liu, H.P. Kriegel, L. Pitsoulis, S. Günnemann, S. Günnemann, Y. Zhou   +6 more
core   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

The Effects of Perinatal Phencyclidine Administration on the Density and Branching of Astrocytes in the Brain of Aged Rats

Acta Veterinaria
Phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate glutamate receptor (NMDA-R), is used for modeling schizophrenia in animals, as NMDA-R hypofunction is vital in its pathophysiology.
Ivaz Sava, Puškaš Nela, Paunović Bojana, Stojković Tihomir, Nikolić Tatjana, Bogosavljević Milica Velimirović, Živković Milica, Petronijević Nataša   +7 more
doaj   +1 more source

Ketamine Hydrochloride - a useful drug for the field immobilization of the Spotted Hyaena Crocuta Crocuta

Koedoe: African Protected Area Conservation and Science, 1973
The use of Ketamine hydrochloride (Vetalar, Parke-Davis) for the capture and restraint of five spotted hyaenas (Crocuta crocuta) is discussed. The wide margin of safety andrelatively short recovery period associated with Ketamine makeit a useful ...
G.L. Smuts
doaj   +1 more source

Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation [PDF]

, 2017
yesRationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly validated ...
Andrew MJ Young, Joanna C Neill, Michael K Harte, Paxinos G, Samantha L McLean, Snigdha S, Yee BK   +6 more
core   +2 more sources

Chiral Metal Halide Perovskites for Spin‐Polarized Light‐Emitting Diodes

Advanced Materials, EarlyView.
Chiral metal–halide perovskites offer a route to circularly polarized light without external polarizers. This Perspective compares two spin‐light emitting diode concepts: intrinsically chiral emissive layers and chiral spin‐filter interlayers that inject spin‐polarized carriers into efficient achiral emitters.
Ashish Gaurav, Jihyun Kim, Nadesh Fiuza‐Maneiro, Hongki Kim, Hae‐Jun Seok, Sergio Gómez Grana, Robert L. Z. Hoye, Lakshminarayana Polavarapu, Matthew J. Fuchter   +8 more
wiley   +1 more source

Clozapine Prevents a Decrease in Neurogenesis in Mice Repeatedly Treated With Phencyclidine

Journal of Pharmacological Sciences, 2007
It has recently been suggested that neurogenesis in the dentate gyrus is decreased in schizophrenia and this phenomenon may contribute to the pathogenesis of the disorder.
Kenji Maeda, Haruhiko Sugino, Tsuyoshi Hirose, Hisashi Kitagawa, Taku Nagai, Hiroyuki Mizoguchi, Kazuhiro Takuma, Kiyofumi Yamada   +7 more
doaj   +1 more source

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Identification of developmentally regulated PCP-responsive non-coding RNA, prt6, in the rat thalamus. [PDF]

PLoS ONE, 2014
Schizophrenia and similar psychoses induced by NMDA-type glutamate receptor antagonists, such as phencyclidine (PCP) and ketamine, usually develop after adolescence.
Hironao Takebayashi, Naoki Yamamoto, Asami Umino, Toru Nishikawa   +3 more
doaj   +1 more source

Aisha Bano - The Role of KCNQ (Kv7) Potassium Channels in Schizophrenia Deficits [PDF]

, 2013
For years, studies have been conducted to treat the positive and negative symptoms and cognitive deficits of schizophrenia; it has allowed to treat the positive symptoms through regulation of dopaminergic neurons and dopamine pathways; however, we still ...
Bano, Aisha
core   +1 more source