Frontiers in Psychiatry, 2021 Introduction: Polypharmacy and genetic variants that strongly influence medication response (pharmacogenomics, PGx) are two well-described risk factors for adverse drug reactions.
Sam Mostafa +9 more
doaj +2 more sources
Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample [PDF]
, 2017 © 2017 The Authors Introduction Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal ...
Boeve, Bradley F +11 more
core +3 more sources
Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD [PDF]
npj Parkinson's DiseaseQuantitative MRI techniques, including quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI), may detect early neurodegenerative changes in ɑ-synucleinopathies, especially within the midbrain.
Zsoka Varga +8 more
doaj +2 more sources
REM Sleep Behaviour Disorder in Multiple System Atrophy: From Prodromal to Progression of Disease [PDF]
Frontiers in Neurology, 2021 A higher frequency of motor and breathing sleep-related disorders in multiple system atrophy (MSA) populations is reported. REM sleep behaviour disorder (RBD) is one of the most robust markers of an underlying alpha-synucleinopathy.
Giulia Giannini +7 more
doaj +3 more sources
NeurologyBackground and Objectives Isolated REM sleep behavior disorder (iRBD) is a prodromal state of α-synucleinopathies, presenting years before overt neurodegenerative disorders.
L. Baldelli +12 more
semanticscholar +2 more sources
CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling. [PDF]
PLoS ONE, 2016 Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower Urinary Tract Symptoms (LUTS).
José A Rodríguez-Nieves +4 more
doaj +3 more sources
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong +11 more
doaj +6 more sources
Glymphatic Function in Prodromal Parkinson's Disease: Associations With Symptoms, Gray Matter Volume, and Phenoconversion Risk. [PDF]
Eur J NeurolGlymphatic dysfunction occurs in Parkinson's disease (PD), but its status in prodromal PD (pPD) is unclear. Using the diffusion tensor imaging along perivascular spaces (DTI‐ALPS) index as an indirect proxy, this study aims to evaluate glymphatic‐related
Chen A +8 more
europepmc +2 more sources
Spiritual Well-Being and Phenoconversion in Huntington's Disease: Analysis from the Prospective Huntington at Risk Observational Study. [PDF]
J Palliat MedObjective: Spiritual well-being (SWB) has been shown to delay the onset of cognitive decline among older adults predisposed to Alzheimer’s disease and related neurodegenerative dementias.
Sokol LL +7 more
europepmc +2 more sources
0417 Preclinical Model to Test Potential Therapeutics to Prevent Phenoconversion of REM Sleep Behavior Disorder to Parkinson’s Disease After Neurotrauma [PDF]
SleepNeurotrauma, including traumatic brain injury (TBI) and/or post-traumatic stress disorder (PTSD), often results in persistent sleep disturbances and impaired neurological function.
Laura Dovek +10 more
semanticscholar +2 more sources