Results 31 to 40 of about 1,759 (167)

Phenoconversion and therapeutic drug monitoring [PDF]

British Journal of Clinical Pharmacology, 2015
Keywords: clobazam; clozapine; genotype–phenotype mismatch; personalized medicine; pharmacogenetics; risperidone; therapeutic drug monitoring ...
Jose de Leon, Jose de Leon, Jose de Leon
openaire   +3 more sources

Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort [PDF]

Neurological Sciences, 2023
AbstractBackgroundA brain glucose metabolism pattern related to phenoconversion in patients with idiopathic/isolated REM sleep behaviour disorder (iRBDconvRP) was recently identified. However, the validation of the iRBDconvRP in an external, independent group of iRBD patients is needed to verify the reproducibility of such pattern, so to increase its ...
Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Claudio Liguori, Francesco Famà, Andrea Donniaquio, Federico Massa, David Vállez García, Sanne K. Meles, Klaus L. Leenders, Agostino Chiaravalloti, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Flavio Nobili, Jee‐Young Lee, Dario Arnaldi   +20 more
openalex   +5 more sources

Differential subcellular expression of P525LFUS as a putative biomarker for ALS phenoconversion [PDF]

Neurology Genetics, 2020
P525LFused-in-Sarcoma ( FUS ) mutation is associated with a specific amyotrophic lateral sclerosis (ALS) phenotype characterized by a juvenile-onset and a severe course.1 This harmful point mutation is located in the nuclear localization signal (NLS) domain at the protein C-terminal.2 Although wild-type FUS protein is expressed almost exclusively in ...
Maria Caputo, Vincenzo La Bella, Antonietta Notaro   +2 more
openalex   +5 more sources

The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

Pharmaceuticals, 2021
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
doaj   +1 more source

Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment ...
Navid Neyshaburinezhad, Mohammad Reza Rouini, Hanieh Entezari, Hoda Lavasani, Yalda Hosseinzadeh Ardakani   +4 more
doaj   +1 more source

Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder [PDF]

Journal of Clinical Medicine, 2021
Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD). Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 ...
Hyunjin Jo, Dongyeop Kim, Jooyeon Song, Sujung Choi, Eunyeon Joo   +4 more
openaire   +3 more sources

Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder

npj Parkinson's Disease, 2022
Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and ...
Li Zhou, Steven W. H. Chau, Yaping Liu, Jing Wang, Jihui Zhang, Ngan Yin Chan, Joey W. Y. Chan, Bei Huang, Sijing Chen, Shirley Xin Li, Vincent Chung Tong Mok, Yun Kwok Wing   +11 more
doaj   +1 more source

‘Phenoconversion’ in adult patients with β‐thalassemia

American Journal of Hematology
Rate and risk factors for phenoconversion from non-transfusion-dependent β-thalassemia (NTDT) to transfusion-dependent β-thalassemia (TDT) during a 10-year follow up of adult patients in Italy.
Khaled M. Musallam, Susanna Barella, Raffaella Origa, Giovanni Battista Ferrero, Roberto Lisi, A Pasanisi, Filomena Longo, Barbara Gianesin, Gian Luca Forni   +8 more
openalex   +5 more sources

Clinical effects of CYP2D6 phenoconversion in patients with psychosis. [PDF]

J Psychopharmacol
Background: Pharmacogenetics is considered a promising avenue for improving treatment outcomes, yet evidence arguing for the use of pharmacogenetics in the treatment of psychotic disorders is mixed and clinical usefulness is under debate.
De Brabander EY, Breddels E, van Amelsvoort T, van Westrhenen R, GROUP Investigators.   +4 more
europepmc   +4 more sources

Pitfalls and challenges associated with phenoconversion in forensic toxcicology

Forensic Science International: Genetics, 2021
In recent years, several publications have demonstrated the interest and the usefulness of pharmacogenetics in forensic toxicology. However, this approach remains namely focused on DNA-based phenotype, which may potentially lead to misinterpretation.
Drevin, G., Picard, N., Jousset, N., Briet, M., Abbara, C.   +4 more
openaire   +4 more sources