Results 71 to 80 of about 1,759 (167)

Brain olfactory‐related atrophy in isolated rapid eye movement sleep behavior disorder

Annals of Clinical and Translational Neurology, 2023
Objective To investigate structural and functional connectivity changes in brain olfactory‐related structures in a longitudinal prospective cohort of isolated REM sleep behavior disorder (iRBD) and their clinical correlations, longitudinal evolution, and
Kyung Ah Woo, Heejung Kim, Eun Jin Yoon, Jung Hwan Shin, Hyunwoo Nam, Beomseok Jeon, Yu Kyeong Kim, Jee‐Young Lee   +7 more
doaj   +1 more source

Hyponatremic Cognitive Dysfunction Resulting from Drug-Drug-Gene Interaction between Sertraline and Cannabidiol in an Intermediate CYP2C19 Metabolizer Patient

INNOVATIONS in Pharmacy, 2022
Background: Pharmacogenomics (PGx) can provide more precision in determining causation of adverse drug reactions (ADRs) from drug-drug-gene interaction clinical application.
Jade Nanan, Sheena Crosby, Michael J. Schuh   +2 more
doaj   +1 more source

Plasma Neurofilament Light Chain and TNF‐α Correlate with Motor Features in Isolated REM Sleep Behavior Disorder

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Isolated RBD (iRBD) is a prominent early marker of Parkinson's disease and related disorders. Objectives Evaluate biomarkers of inflammation and axonal damage people with iRBD for disease progression. Methods Plasma samples from 27 video‐polysomnography confirmed iRBD patients and 25 controls were analyzed for inflammatory ...
Brook Huxford, Cristina Simonet, Laura Pérez‐Carbonell, Guy Leschziner, Anette Schrag, Ruth Dobson, Alastair J. Noyce   +6 more
wiley   +1 more source

Pharmacist assessment of drug-gene interactions and drug-induced phenoconversion in major depressive disorder: a case report [PDF]

, 2022
Nicole Marie Del Toro-Pagán, Adriana Matos, Chandni Bardolia, Véronique Michaud, Jacques Turgeon, Nishita Shah Amin   +5 more
openalex   +1 more source

Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The basal forebrain (BF), a key cholinergic structure, is a site of known pathology in later stages of Lewy body disorders.
Lachlan Churchill, Ajay Konuri, Anna Ignatavicius, Jack Anderson, Simon J.G. Lewis, Elie Matar   +5 more
wiley   +1 more source

Derivation and Validation of a Phenoconversion‐Related Pattern in Idiopathic Rapid Eye Movement Behavior Disorder [PDF]

, 2022
Pietro Mattioli, Beatrice Orso, Claudio Liguori, Francesco Famà, Laura Giorgetti, Andrea Donniaquio, Federico Massa, Andrea Giberti, David Vállez García, Sanne K. Meles, Klaus L. Leenders, Fabio Placidi, Matteo Spanetta, Agostino Chiaravalloti, Riccardo Camedda, Orazio Schillaci, Francesca Izzi, Nicola Biagio Mercuri, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Flavio Nobili, Dario Arnaldi   +22 more
openalex   +1 more source

Dysphagia in Huntington's Disease: An Evaluation of Swallowing Disturbance across the HD‐ISS Staging Spectrum

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background The onset and pattern of progression of swallowing impairment in HD remain poorly understood. The Swallowing Disturbance Questionnaire (SDQ) has proven useful in assessing dysphagia across various neurological conditions, but its use in HD remains largely unexplored. Objectives To evaluate swallowing difficulties in HD using the SDQ
Japleen Kaur, Krisha Bagga, Paul E. Gilbert, Jody Corey‐Bloom   +3 more
wiley   +1 more source

Assessing user perspectives on clinical pharmacogenomics consultation documentation: a user-centered evaluation

Frontiers in Pharmacology
The University of Florida Health Precision Medicine Program plays a crucial role in delivering pharmacogenomics (PGx) result notes to providers who request PGx testing.
Nina Desai, Namratha Ravindra, Bradley Hall, Hana Al Alshaykh, Hana Al Alshaykh, Lauren Lemke, Eda Eken, Emily J. Cicali, Kristin Wiisanen, Larisa H. Cavallari, Khoa A. Nguyen   +10 more
doaj   +1 more source

Using a Brief Body Sway Assessment Device to Track Balance Differences across the Huntington's Disease Integrated Staging System Spectrum

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin gene on chromosome 4, leading to progressive cognitive decline, motor impairment, and functional disability. Although balance impairment is recognized in HD, its onset and evolution with disease stage remain poorly ...
Japleen Kaur, Nadeen Youhanan, Krisha Bagga, Andrew Hall, Paul E. Gilbert, Daniel J. Goble, Jody Corey‐Bloom   +6 more
wiley   +1 more source

Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies

Movement Disorders, EarlyView.
Abstract Background Plasma biomarkers of neurodegeneration, astrogliosis, and neuroinflammation have been studied as potential biomarkers in neurodegenerative diseases. This study investigated whether these markers may predict phenoconversion to Parkinson's disease or dementia with Lewy bodies (DLB) in idiopathic/isolated REM sleep behavior disorder ...
Aline Delva, Cinzia Zatti, Amélie Pelletier, Jacques Montplaisir, Jean‐François Gagnon, Gwendlyn Kollmorgen, Tony Kam‐Thong, Thomas Kustermann, Venissa Machado, Ronald B. Postuma   +9 more
wiley   +1 more source