Results 71 to 80 of about 3,784 (223)

Phenoconversion of CYP2D6 by inhibitors modifies aripiprazole exposure [PDF]

European Archives of Psychiatry and Clinical Neuroscience, 2019
The efficacy of aripiprazole therapy and the risk of adverse reactions are influenced by substantial inter-individual variability in aripiprazole metabolizing capacity. In vitro studies assigned the potential role in aripiprazole metabolism to CYP2D6 and CYP3A enzymes; therefore, the association between the steady-state aripiprazole plasma ...
Ádám Kiss, Ádám Menus, Katalin Tóth, Máté Déri, Dávid Sirok, Evelyn Gabri, Ales Belic, Gábor Csukly, István Bitter, Katalin Monostory   +9 more
openaire   +3 more sources

Drug-drug-gene interactions and adverse drug reactions [PDF]

, 2020
The economic and health burden caused by adverse drug reactions has increased dramatically in the last few years. This is likely to be mediated by increasing polypharmacy, which increases the likelihood for drug-drug interactions.
Malki, Mustafa Adnan, Pearson, Ewan Robert   +1 more
core   +2 more sources

Relationship of Mediterranean Diet and Caloric Intake to Phenoconversion in Huntington Disease [PDF]

JAMA Neurology, 2013
Adherence to Mediterranean-type diet (MeDi) may delay onset of Alzheimer and Parkinson diseases. Whether adherence to MeDi affects time to phenoconversion in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown.To determine if MeDi modifies the time to clinical onset of HD (phenoconversion) in premanifest carriers participating
Karen Marder
openalex   +6 more sources

Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion [PDF]

International Journal of Molecular Sciences, 2019
The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named cardiosomes when deriving from cardiomyocytes) allows their active transportation and ensures cell-cell communication. We hypothesize that cardiosomal miRNAs play a pivotal role in the activation of myofibroblasts following ischemic injury.
Morelli Marco Bruno, Shu J, Sardu Celestino, Matarese Alessandro, Santulli Gaetano   +4 more
openaire   +5 more sources

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers. [PDF]

, 2019
Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Gunter, Jeffrey L, Haley, Dana, Jones, David, Kantarci, Kejal, Knopman, David, Kraft, Ruth, Lapid, Maria, Lesnick, Timothy, Rademakers, Rosa, Rosen, Howie, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +22 more
core   +3 more sources

CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting

Frontiers in Pharmacology, 2021
Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes P450 are among the most studied enzymes from a pharmacokinetic point of view.
Kuntheavy Ing Lorenzini, Jules Desmeules, Victoria Rollason, Stéphane Bertin, Marie Besson, Youssef Daali, Caroline F. Samer   +6 more
doaj   +1 more source

Case Report: Performing a Medication Safety Review Assisted by Pharmacogenomics to Explain a Prescribing Cascade Resulting in a Patient Fall

Medicina, 2023
Pharmacotherapy for major depressive disorder (MDD) typically consists of trial-and-error and clinician preference approaches, where patients often fail one or more antidepressants before finding an optimal regimen.
Joshua Russell, Meghan J. Arwood, Nicole M. Del Toro-Pagán, Nishita S. Amin, Michele D. Cambridge, Jacques Turgeon, Veronique Michaud   +6 more
doaj   +1 more source

The Impact of Striatal Dopaminergic Deficits and Alpha‐Synucleinopathy on Cognitive Function in REM Sleep Behavior Disorder [PDF]

Alzheimers Dement
Abstract Background Presynaptic protein α‐synuclein (αSyn) plays a role in Alzheimer's disease (AD) and Parkinson's disease (PD) with evidence suggesting αSyn pathology preceding and driving striatal dopaminergic neurodegeneration in PD. Elevated cerebrospinal fluid (CSF) αSyn seeding activity and reduced striatal dopaminergic activity are associated ...
Reddy V, Cedarbaum J, Seibyl J, Mead K, Renkl E, Patel S, Esposito S, Moret S, Lawrence M, Vin R, Fredericks C.   +10 more
europepmc   +2 more sources

Increased Transferrin Sialylation Predicts Phenoconversion in Isolated REM Sleep Behavior Disorder [PDF]

Movement Disorders, 2022
AbstractBackgroundSialic acid–protein interactions are involved in regulating central nervous system immunity; therefore, derangements in sialylation could be involved in neurodegeneration.ObjectivesWe evaluate the differences in serum transferrin sialylation in prodromal and early‐stage Parkinson's disease (PD), its relation to substantia nigra ...
Ranjani Ganapathy S., Kateřina Levová, Lenka Kotačková, Jiří Trnka, David Zogala, Jan Rusz, Tomáš Zima, David Devos, Karel Šonka, Evžen Růžička, Marta Kalousová, Petr Dušek   +11 more
openaire   +2 more sources

Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing [PDF]

, 2019
PURPOSE: A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process
Beitelshees, Amber L., Bell, Gillian C., Bishop, Jeffrey R., Blake, Kathryn, Cavallari, Larisa H., Crona, Daniel J., Dressler, Lynn, Duong, Benjamin Q., Empey, Philip E., Gregg, Ryan A., Hicks, J. Kevin, Hines, Lindsay J., Johnson, Julie A., Lee, James C., Limdi, Nita A., Obeng, Aniwaa Owusu, Peterson, Josh F., Pratt, Victoria M., Prows, Cynthia A., Ramsey, Laura B., Scott, Stuart A., Shelton, Richard C., Skaar, Todd C., Smith, D. Max, Tuteja, Sony, Van Driest, Sara L., Weitzel, Kristin Wiisanen   +26 more
core   +1 more source