Results 51 to 60 of about 2,829,895 (306)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Development of phenolic concrete mixes and structural behaviour of phenolic concrete components [PDF]
, 1991 This work relates to the development of a method of preparing a filled phenolic resin, for use particularly, but not exclusively, in building materials. The method includes mixing filler and micro-filler, a catalyst, resin and a hetrocyclic alcohol (i.e.
Shariatmadari, Ali Akbar +1 more
core
Assessment of the genotoxicity of olive mill waste water (OMWW) with the Vicia faba micronucleus test [PDF]
, 2007 The present study concerns the genotoxicity of olive mill waste water (OMWW) generated in mills producing olive oil in Morocco. The Vicia faba micronucleus test was used to evaluate the genotoxicity of OMWW and the six major phenolic compounds identified
Hafidi, Mohamed +7 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Changes in phenolic profiles and antioxidant activity in rabbiteye blueberries during ripening
International Journal of Food Properties, 2019 Blueberry (Vaccinium spp.) is a widely consumed fruit worldwide. Anthocyanins, phenolic acids, and flavonoids are the main bioactive compounds of blueberry.
Xie Guofang +4 more
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Accumulation of Phenolic Acids during Storage over Differently Handled Fresh Carrots
Foods, 2020 Carrots contain a significant content of phenolic compounds, mainly phenolic acids. Technological processing of carrots inflicts wounding stress and induces accumulation of these compounds, especially caffeic acid derivatives, in the periderm tissue.
Jarkko Hellström +2 more
doaj +1 more source
Real time NMR analyses of phenolic resin reactions [PDF]
, 2008 The current investigation presents the development and application of a Rapid NMR acquisition method, capable of identifying transient species and quantitatively monitoring their changes in real time during an in situ phenolic resin preparation.
Woolley, Samuel Lindsay
core
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source