Results 51 to 60 of about 236,708 (310)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
The Study of the Antioxidant Activity of Phenolic Components of Manuka Honey [PDF]
, 2011 The phenolic compounds of honey have been known to pose significantly antioxidant activity, including iron-binding and free radical scavenging activity. Manuka honey has been widely used in wound treatment and the antioxidant activity of manuka honey is ...
Wang, Hao
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Effect of Storage Temperature on Vitamin C, Total Phenolics, UPLC Phenolic Acid Profile and Antioxidant Capacity of Eleven Potato (Solanum tuberosum) Varieties [PDF]
, 2017 Storage of potato tubers at low temperature affects their metabolism and may alter their phytochemical properties. There is a need to elucidate the changes in antioxidant compounds, activity and enzymes during storage of tubers.
Avadh K. Shah +13 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Development of phenolic concrete mixes and structural behaviour of phenolic concrete components [PDF]
, 1991 This work relates to the development of a method of preparing a filled phenolic resin, for use particularly, but not exclusively, in building materials. The method includes mixing filler and micro-filler, a catalyst, resin and a hetrocyclic alcohol (i.e.
Shariatmadari, Ali Akbar +1 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Comparative study of total phenolic content and radical scavenging activity of conventionally and organically grown herbs [PDF]
, 2010 The aim of the present study was to measure the relative phenolic content in commonly available conventionally and organically grown herbs and to evaluate their antioxidant capacity.
Todorova, M. +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Real time NMR analyses of phenolic resin reactions [PDF]
, 2008 The current investigation presents the development and application of a Rapid NMR acquisition method, capable of identifying transient species and quantitatively monitoring their changes in real time during an in situ phenolic resin preparation.
Woolley, Samuel Lindsay
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source