Results 61 to 70 of about 86,343 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Detection of phenolics in the PECCs.

, 2017
Hand sections through a C. mollis leaf as a control plant (A) and PECCs in F. tataricum (B) visualised under UV light, showing the blue autofluorescence of phenolics. The presence of phenolics in a vacuole is marked by a yellow arrow.
Yulia Kostyukova (3826714), Natalya Rumyantseva (3826717), Magdalena Rojek (3366221), Jolanta Kwasniewska (514959), Robert Hasterok (17853), Alexander Betekhtin (112378), Anna Milewska-Hendel (3366215), Ewa Kurczynska (3366227), Joanna Jaskowiak (2816794)   +8 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effect of Enzyme-Assisted Vinification on Wine Phenolics, Colour Components, and Antioxidant Capacity

Polish Journal of Food and Nutrition Sciences, 2020
The aim of this study was to evaluate the impact of the macerating enzyme addition (Sihazym Extro and Vinozym Vintage) on the extraction of phenolics, colour components, and antioxidants in Babica wine.
Ivana Generalić Mekinić, Živko Skračić, Ana Kokeza, Barbara Soldo, Ivica Ljubenkov, Mara Banović, Vida Šimat, Danijela Skroza   +7 more
doaj   +1 more source

HPLC analysis of phenolics / organic acids.

, 2022
(a) Phenolic / organic acids in CFS of Loig. coryniformis BCH-4. (b) Standards of phenolics / organic acids. (DOCX)
Iqra Gill (13190013), Abdul Tawab (5328206), Muhammad Rizwan Javed (11172647), Shazia Naheed (13190010), Muhammad Abid (2154517), Mahwish Salman (5351741), Hazrat Ali (421019), Anam Tariq (9275678), Tanzila Sahar (13190007), Ghulam Mustafa (458105)   +9 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Four distinct pathways involved in a “tug-of-war” lead to the non-linear nature of phenolic chemistry during lactic acid fermentation of fruits and vegetables

Journal of Advanced Research
Introduction: Lactic acid fermentation of fruits and vegetables (F&V) is endowed with new nutrients and flavors. “Phenolics” is a hot spot in this area, which evolve irregularly during fermentation. However, the mechanism about this non-linear phenomenon
Yuqing Duan, Fanqiang Meng, Sivakumar Manickam, Xinyao Zhu, Jie Yang, Yongbin Han, Yang Tao   +6 more
doaj   +1 more source

PENGARUH RASIO PELARUT TERHADAP EKSTRAKSI DARI KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)

Kovalen: Jurnal Riset Kimia, 2019
This study aims to determine the effect of the ratio of solvents to extract yield, phenolics total and IC50 values ​​of red dragon fruit peel and also get the optimal solvent ratio to obtain extract yield, phenolics total and the highest or best IC50 ...
Amalia Noviyanty, Chitra Anggriani Salingkat, Syamsiar Syamsiar   +2 more
doaj   +1 more source

Determination of free phenolics and combined phenolics in foliage of Magnolia sieboldii K. Koch

, 2016
In order to further understand the type and content of phenolics of Magnolia sieboldii K. Koch, the method of high performance liquid chromatography (HPLC) was used for measuring qualitatively and quantitatively free phenolics, combined phenolics and ...
Du Fengguo, Gao Hongbing, Wang Huan
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source