Results 61 to 70 of about 5,719,995 (296)

Phenotypic aging mediates the association between neutrophil percentage-to-albumin ratio and muscular dystrophies: a population-based study

Frontiers in Neurology
BackgroundCurrent research on Muscular Dystrophies (MD) suggests that its occurrence is closely related to several mechanisms, including gene mutations, dystrophin deficiency, and alterations in the Akt/mTOR/p70S6K signaling pathway.
Hongyang Gong, Hongyang Gong, Jiajun Wang, Xiaomei Lin, Shaoqun Huang   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Phenotypic changes in different spinach varieties grown and selected under organic conditions [PDF]

, 2011
Organic and low-input agriculture needs flexible varieties that can buffer environmental stress and adapt to the needs of farmers. We implemented an experiment to investigate the evolutionary capacities of a sample of spinach (Spinacia oleracea L ...
Goldringer, I., Chable, V., Goldringer, Isabelle, Edith T. Lammerts van Bueren, Lammerts Van Bueren, E., Schermann, Nicolas, Nicolas Schermann, Serpolay, Estelle, Schermann, N., Isabelle Goldringer, Dawson, J.C., Chable, Veronique, Julie Dawson, Estelle Serpolay, Véronique Chable, Serpolay, E., Lammerts van Bueren, Edith, Dawson, Julie   +17 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Current marijuana use is cross-sectionally associated with accelerated biological aging among U.S. adults: exploring mediating effect of blood cadmium

The Journal of Nutrition, Health and Aging
Background: Global marijuana use has risen markedly in recent decades. Although prior research suggests that marijuana use is associated with epigenetic alterations, its relationship with biological aging remains unclear.
Kai Wei, Xiaotong Chen
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.

PLoS Medicine, 2018
BackgroundA person's rate of aging has important implications for his/her risk of death and disease; thus, quantifying aging using observable characteristics has important applications for clinical, basic, and observational research.
Zuyun Liu, Pei-Lun Kuo, Steve Horvath, Eileen Crimmins, Luigi Ferrucci, Morgan Levine   +5 more
doaj   +1 more source

Bauch_etal_data_Telomeres-and-phenotypic-quality-ProcRSocB

, 2013
Bauch_etal_data_Telomeres-and-phenotypic-quality ...
Peter H. Becker (2913659), Christina Bauch (3192042), Simon Verhulst (143968)   +2 more
core   +1 more source