Results 51 to 60 of about 5,719,995 (296)
Increased Rate of Epigenetic Aging in Men Living With HIV Prior to Treatment
Frontiers in Genetics, 2022 Background: Epigenetic aging is accelerated in tissues of persons living with HIV (PLWH) and may underlie the early onset of age-related illnesses. This study examines the rate-of-change in epigenetic age in PLWH following HIV infection but before HAART,
Mary E. Sehl +13 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Evaluation of a Computable Phenotype for Successful Cognitive Aging
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2023 AbstractBackgroundStudying successful cognitive aging presents an opportunity to identify factors that may mitigate risk for Alzheimer’s disease and related disorders to inform public health initiatives, community interventions, and policy. Yet, identifying these cohorts is challenging, especially at advanced ages. Commutable phenotype algorithms using
Glenn Smith +6 more
openaire +3 more sources
Kilkenny: age friendly county strategy [PDF]
, 2010 This document outlines a new and ambitious plan to improve the lives and well being of all older adults in Kilkenny. The strategy has been developed as a result of detailed consultation with the older people of Kilkenny, the agencies and service ...
Kilkenny Age Friendly County Alliance
core
Glacial history affected phenotypic differentiation in the Alpine plant Campanula thyrsoides [PDF]
, 2013 Numerous widespread Alpine plant species show molecular differentiation among populations from distinct regions. This has been explained as the result of genetic drift during glacial survival in isolated refugia along the border of the European Alps ...
Scheepens J. F. +11 more
core +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Yogurt consumption and risk of accelerated aging: A population-based study from the NHANES 2003–2006
Frontiers in NutritionIntroductionYogurt consumption is beneficial to health, but its association with aging remains unclear. This study aims to explore the relationship between yogurt consumption and aging using data from the 2003–2006 National Health and Nutrition ...
Xinghai Yue +5 more
doaj +1 more source
Generalized Norms of Reaction for Ecological Developmental Biology [PDF]
, 2002 A standard norm of reaction (NoR) is a graphical depiction of the phenotypic value of some trait of an individual genotype in a population as a function of an environmental parameter. NoRs thus depict the phenotypic plasticity of a trait. The topological
Sarkar, Sahotra, Fuller, Trevon
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source