Results 41 to 50 of about 5,719,995 (296)

Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013–2016

Frontiers in Public Health
IntroductionPopulation aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) is a widely used industrial chemical with potential health risks,
Xinyun Chen, Fangyu Shi, Wenhui Yu, Chunying He, Shenju Gou, Ping Fu   +5 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors

Frontiers in Immunology, 2020
MotivationPeople with HIV on successful antiretroviral therapy show signs of premature aging and are reported to have higher rates of age-associated comorbidities.
Davide De Francesco, Caroline A. Sabin, Peter Reiss, Peter Reiss, Peter Reiss, Neeltje A. Kootstra   +5 more
doaj   +1 more source

Association between life’s essential 8 and biological ageing among US adults

Journal of Translational Medicine, 2023
Background Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life’s Essential 8 (LE8), a currently updated measure of cardiovascular health (CVH), and biological ageing.
Ronghuai Zhang, Min Wu, Wei Zhang, Xuna Liu, Jie Pu, Tao Wei, Zhanfang Zhu, Zhiguo Tang, Na Wei, Bo Liu, Qianwei Cui, Junkui Wang, Fuqiang Liu, Ying Lv   +13 more
doaj   +1 more source

Phenotype of Normal Spirometry in an Aging Population [PDF]

American Journal of Respiratory and Critical Care Medicine, 2015
Abstract Rationale In aging populations, the commonly used Global Initiative for Chronic Obstructive Lung Disease (GOLD) may misclassify normal spirometry as respiratory impairment (airflow obstruction and restrictive pattern), including the presumption of respiratory disease (chronic ...
Fragoso, Carlos A Vaz, McAvay, Gail, Van Ness, Peter H, Casaburi, Richard, Jensen, Robert L, MacIntyre, Neil, Gill, Thomas M, Yaggi, H Klar, Concato, John   +8 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Biological aging matters: a cross-sectional study uncovering the association between phenotypic age acceleration and erectile dysfunction based on 2360 male individuals

The Aging Male
Background The current study aimed to explore the potential associations between Phenotypic Age (PhenoAge)/PhenoAge acceleration (PhenoAgeAccel) and erectile dysfunction (ED).Methods We carried out a cross-sectional study based on data from 2360 male ...
Fan Dong, Ping Ping, Yi Ma, Xiang-Feng Chen   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prediction of biological age and blood biomarkers from DNA methylation profiles measured by the methylation screening array: development and validation of models on Japanese data

Epigenetics Reports
Epigenetic clocks based on DNA methylation (DNAm) are widely used indicators of biological aging; however, most models were developed using EPIC arrays and non-Japanese populations.
Tatsuma Shoji, Yui Tomo, Ryo Nakaki
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source