Results 91 to 100 of about 5,699,048 (257)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner, Hoffmann, D., Assfalg-Machleidt, Irmgard, Helm, K. von der, Nitschko, H., Koszinowski, U.   +5 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Synergistic impact of 25-hydroxyvitamin D concentrations and physical activity on delaying aging

Redox Biology
Objective: Our study aims to examine the independent and combined associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations and physical activity (PA) status with phenotypic age (PhenoAge).
Chang Liu, Lin Hua, Zhong Xin
doaj   +1 more source

Dry ageing: A physiologically realistic alternative to accelerated ageing for phenotyping seed longevity in soybean

Plant Science Today
Seed longevity is a vital trait that influences germplasm storability and seed quality maintenance. The accelerated ageing test (AAT) is often used to measure longevity, but its high-temperature and humidity conditions do not truly represent natural seed ageing.
A Akash, M B Ratnaparkhe, C T M Prasad, B K Naik, M K Kuchlan, H R Archana, S Bhattacharjee, S K Lal, D Vijay, M B Arun Kumar   +9 more
openaire   +1 more source

Age & Opportunity annual report 2011

, 2012
Strategic report for Age & Oppertunity ...
Age & Opportunity
core  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Interpretable prediction of coronary heart disease risk in adults over 50 with accelerated aging using 45 dietary nutrients

Frontiers in Nutrition
BackgroundThe relationship between dietary nutrient intake and coronary heart disease (CHD) risk among older adults with accelerated aging remains inadequately understood.MethodsThis study analyzed data from seven cycles of the National Health and ...
Zhi-qiang Yang, Xiao-hong Zhang
doaj   +1 more source

Computational models for prediction of yeast strain potential for winemaking from phenotypic profiles [PDF]

, 2013
Saccharomyces cerevisiae strains from diverse natural habitats harbour a vast amount of phenotypic diversity, driven by interactions between yeast and the respective environment. In grape juice fermentations, strains are exposed to a wide array of biotic
Mendes, Mendes, Dequin, Sylvie, Schuller, Dorit, João Drumonde-Neves, Ricardo Franco-Duarte, Inês Mendes, João Drumonde-Neves (433942), Mendes Inês, Fonseca Elza, Elza Fonseca (433941), Schuller, Dorit Elisabeth, Fonseca, Elza, Zupan Blaz, Lan Umek, Schuller Dorit, Sylvie Dequin (205208), Dorit Schuller (181699), Franco-Duarte, Ricardo, Sylvie Dequin, Dequin Sylvie, Dorit Schuller, Zupan, Blaz, Umek, Lan, Drumonde-Neves João, Mendes, Inês Isabel Moreira Moutinho Vieira, Lan Umek (433940), Drumonde-Neves, Joao, Umek Lan, Inês Mendes (433938), Elza Fonseca, Blaz Zupan (10031), Mendes, Ines, Franco-Duarte Ricardo, Ricardo Franco-Duarte (433939), Blaz Zupan   +34 more
core   +2 more sources