Results 71 to 80 of about 5,699,048 (257)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Accelerated aging mediates the association between fecal incontinence and mortality: Evidence from the National Health and Nutrition Examination Survey

Journal of International Medical Research
Objective This study was designed to examine the relationship between fecal incontinence and accelerated aging, determine its association with mortality risk, and evaluate whether accelerated aging mediates the link between fecal incontinence and ...
Yizhou Lu, Zixin Yu, Hongxin Chen, Hong Shen   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target

Environment International
Introduction: Although previous studies investigated the potential adverse effects of endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related diseases, the mixed effect of multiple types of EDCs on biological age ...
Weichao Huang, Zilong Zhang, Manuel Colucci, Linghui Deng, Mi Yang, Xinyi Huang, Xianghong Zhou, Yumin Jin, Edoardo Lazzarini, Carolina Balbi, Oriol Juanola, Aurora Valdata, Silvia Bressan, Yu Zhan, Fang Qi, Qiang Wei, Lu Yang, Xiaoli Zou, Shi Qiu   +18 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Photon acceleration by laser produced wakefields on Astra [PDF]

, 2004
This chapter looks at photon acceleration by laser produced wakefields on ...
Thomas, A.G.R., Trines, Raoul M. G. M., Mangles, S.P.D., Norreys, P.A., Bingham, Robert, Divall, E.J., Najmudin, Z, Foster, P.S., Langley, A.J., Collier, J.L., Hooker, C.J., Viskup, Richard, Jaroszynski, Dino, Reitsma, Albert, Gallacher, J. G., Krushelnick, K., Murphy, C.D., Smith, J,M.   +17 more
core   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Interaction between Noise Exposure and Phenotypic Age Acceleration in Hearing Loss: An NHANES Study

Hearing loss is a growing public health burden, and aging and occupational noise exposure are two major contributors. This cross-sectional study examined whether phenotypic age acceleration interacts with occupational noise exposure in relation to ...
Wu Congcong, Dai Junjian, Zhu Changsen, Lv Tian, Xiong Siqi, Yu Xiao   +5 more
core   +1 more source

Additional acceleration of solar-wind particles in current sheets of the heliosphere [PDF]

, 2015
Particles of fast solar wind in the vicinity of the heliospheric current sheet (HCS) or in a front of interplanetary coronal mass ejections (ICMEs) often reveal very peculiar energy or velocity profiles, density distributions with double or triple peaks,
V. Zharkova, Khabarova, Olga, V. Zharkova, O. Khabarova, Zharkova, Valentina   +4 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source