Results 51 to 60 of about 5,699,048 (257)

Phenotypic plasticity of senescence inDaphniaunder predation impact: no ageing acceleration when the perceived risk decreases with age [PDF]

Royal Society Open Science, 2020
Recognising the nature of the predation risk, and responding to it accurately, is crucial to fitness. Yet, even the most accurate adaptive responses to predation risk usually entail costs, both immediate and lifelong. Rooting in life-history theory, we hypothesize that an animal can perceive the nuances of prey size and age selectivity by the predator ...
Barbara Pietrzak, Max Rabus, Maciej Religa, Christian Laforsch, Maciej J. Dańko   +4 more
openaire   +3 more sources

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

eLife, 2022
Transposable elements (TEs) are mobile sequences of DNA that can become transcriptionally active as an animal ages. Whether TE activity is simply a by-product of heterochromatin breakdown or can contribute toward the aging process is not known. Here, we place the TE gypsy under the control of
Joyce Rigal, Ane Martin Anduaga, Elena Bitman, Emma Rivellese, Sebastian Kadener, Michael T. Marr   +5 more
openaire   +3 more sources

Acceleration in turbulent channel flow

, 2010
We use Direct Numerical Simulations of turbulent channel flow to study the acceleration A corresponding to the full fluid velocity u and the acceleration a corresponding to the fluctuating velocity u? ? u?hui where hui is the mean flow.
S. W. Coleman, Z. Hu, Chen, L., Vassilicos, J.C., L. Chen, Hu, Zhiwei, Coleman, S.W., J. C. Vassilicos   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The association between SII and aging: evidence from NHANES 1999–2018

Frontiers in Public Health
BackgroundThe study aimed to examine the association between the systemic immune-inflammation index (SII), a contemporary metric of systemic inflammatory response, and biological aging, which are closely interconnected processes.MethodsThis cross ...
Nanbu Wang, Lian Ren, Ziyuan Li, Yunhao Hu, Jingpei Zhou, Quan Sun, Bin Pei, Xinyu Li, Wanqing Peng, Jinyan Yu, Renhui Zhao, Ziting Huang, Zhenhu Chen, Guoxin Huang   +13 more
doaj   +1 more source

Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer

Aging
Epigenetic clocks, estimated via DNA methylation (DNAm), reflect individuals' biological aging in multiple tissues and are associated with age-related diseases, but their functional role in colorectal cancer (CRC), an age-associated disease, remains unconclusive.
Jung, Su Yon, Pellegrini, Matteo, Tan, Xianglong, Yu, Herbert   +3 more
openaire   +2 more sources

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue [PDF]

Aging Cell, 2010
SummaryThe free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. Its role in aging of the connective tissue has not yet been established, even though the incidence of aging‐related disorders in connective tissue‐rich organs is high, causing major disability ...
Nicolai, Treiber, Pallab, Maity, Karmveer, Singh, Matthias, Kohn, Alexander F, Keist, Florentina, Ferchiu, Lea, Sante, Sebastian, Frese, Wilhelm, Bloch, Florian, Kreppel, Stefan, Kochanek, Anca, Sindrilaru, Sebastian, Iben, Josef, Högel, Michael, Ohnmacht, Lutz E, Claes, Anita, Ignatius, Jin H, Chung, Min J, Lee, York, Kamenisch, Mark, Berneburg, Thorsten, Nikolaus, Kerstin, Braunstein, Anne-Dorte, Sperfeld, Albert C, Ludolph, Karlis, Briviba, Meinhard, Wlaschek, Lore, Florin, Peter, Angel, Karin, Scharffetter-Kochanek   +29 more
openaire   +2 more sources

Acceleration: An interpretive study of gifted students within a primary school setting [PDF]

, 2009
The purpose of this study was to investigate the experiences of gifted Primary School aged students who had been year level accelerated in Western Australia.
Gamble, Christina
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype [PDF]

International Immunology, 2008
We and others recently described a method for isolating viable forkhead boxp3 (FoxP3(+)) T regulatory cells (Tregs) by means of the surface phenotype CD4(+)CD127(lo)CD25(+). In this study, we used the new strategy to measure Treg numbers, phenotype and function at different ages.
Brigitte, Santner-Nanan, Nabila, Seddiki, Erhua, Zhu, Verena, Quent, Anthony, Kelleher, Barbara, Fazekas de St Groth, Ralph, Nanan   +6 more
openaire   +2 more sources