Results 31 to 40 of about 5,699,048 (257)

Human immune phenotyping reveals accelerated aging in type 1 diabetes

JCI Insight, 2023
The proportions and phenotypes of immune cell subsets in peripheral blood undergo continual and dramatic remodeling throughout the human life span, which complicates efforts to identify disease-associated immune signatures in type 1 diabetes (T1D).
Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, Puchong Thirawatananond, Amanda L. Posgai, Leeana Peters, Keshav Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, Clive H. Wasserfall, Michael J. Haller, Desmond A. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda L. Bacher, Todd M. Brusko   +19 more
openaire   +3 more sources

Determination of the phenotypic age in residents of Mexico City: effect of accelerated ageing on lung function and structure [PDF]

ERJ Open Research, 2020
IntroductionPhenotypic age better represents age-related biological dysregulation than chronological age. Recently, a multisystem-based ageing measure, which integrates chronological age and nine biomarkers, was proposed.MethodsPhenotypic age was determined in 774 residents of Mexico City over 60 years old and without respiratory problems.
Ivette Buendía-Roldan, Rosario Fernández-Plata, Abigail Valdes-Bartolo, Mayra Mejia, Luis E. Jaramillo, David Martínez-Briseño, Armando Santiago-Ruiz, Hugo Tapia-Aguilar, Brenda Gómez-Zamora, Annie Pardo, Moises Selman   +10 more
openaire   +3 more sources

Association of Phenotypic Aging Marker with comorbidities, frailty and inflammatory markers in people living with HIV

BMC Geriatrics, 2022
Background Aging characteristics in people living with HIV (PLWH) are heterogeneous, and the identification of risk factors associated with aging-related comorbidities such as neurocognitive impairment (NCI) and frailty is important.
Win Min Han, Tanakorn Apornpong, Sivaporn Gatechompol, Sasiwimol Ubolyam, Pairoj Chattranukulchai, Lalita Wattanachanya, Sarawut Siwamogsatham, Stephen J. Kerr, Kristine M. Erlandson, Anchalee Avihingsanon   +9 more
doaj   +1 more source

Epigenetic Age Acceleration Assessed with Human White-Matter Images [PDF]

, 2017
Item does not contain fulltextThe accurate estimation of age using methylation data has proved a useful and heritable biomarker, with acceleration in epigenetic age predicting a number of age-related phenotypes.
Blangero, J., Almasy, L., Hodgson, K., Goring, H.H., Knowles, E.E., Olvera, R.L., Curran, J.E., Carless, M.A., Mathias, S., Duggirala, R., Yao, N., Fox, P.T., Sprooten, E., Glahn, D.C., Kulkarni, H.   +14 more
core   +2 more sources

The L-shaped link between total antioxidant capacity and phenotypic age acceleration: evidence from NHANES 2003–2010 [PDF]

Biogerontology
Wu Y, Xiang M, Zhao Y, Zhang Y, Cheng W, Deng J.   +5 more
exaly   +2 more sources

Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway [PDF]

Scientific Reports, 2020
AbstractHypercholesterolemia accelerates the phenotypes of aging in hematopoietic stem cells (HSCs). As yet, little is known about the underlying mechanism. We found that hypercholesterolemia downregulates Ten eleven translocation 1 (Tet1) in HSCs.
Tie, Guodong, Yan, Jinglian, Khair, Lyne, Tutto, Amanda A., Messina, Louis M.   +4 more
openaire   +3 more sources

AKR breakup and auroral particle acceleration at substorm onset [PDF]

, 2008
The dynamical behavior of auroral kilometric radiation (AKR) is investigated in connection with auroral particle acceleration at substorm onsets using high-time-resolution wave spectrograms provided by Polar/PWI electric field observations.
Morioka, A., Yumoto, K., Honary, Farideh, Misawa, H., Anderson, R.R., Donovan, E.F., Spanswick, E., Tsuchiya, F., Miyoshi, Y., Parks, G.K., Menietti, J.D.   +10 more
core   +4 more sources

Association of ultra-processed foods with phenotypic age acceleration in US adults: a mediation analysis of body mass index in the NHANES [PDF]

Frontiers in Nutrition
Kong Weiliang
exaly   +2 more sources

Association between work characteristics and epigenetic age acceleration: cross-sectional results from UK – Understanding Society study [PDF]

, 2022
Occupation-related stress and work characteristics are possible determinants of social inequalities in epigenetic aging but have been little investigated.
Vineis, Paolo, Ala-Mursula, Leena, Järvelin, M.-R. (Marjo-Riitta), Virtanen, Marianna, Virtanen, M. (Marianna), Fiorito, G. (Giovanni), Robinson, O. (Oliver), Freni-Sterrantino, A, Fiorito, Giovanni, Freni-Sterrantino, Anna, Vineis, P. (Paolo), Freni Sterrantino, Anna, Ala-Mursula, L, Fiorito, G, Jarvelin, M-R, Robinson, Oliver, d'Errico, A, Freni-Sterrantino, A. (Anna), D'errico, Angelo, Virtanen, M,, Robinson, O, d’Errico, A. (Angelo), Ala-Mursula, L. (Leena), Vineis, P, d’Errico, Angelo, Jarvelin, Marjo-Riitta   +25 more
core   +1 more source

Association between life’s essential 8 and biological ageing among US adults

Journal of Translational Medicine, 2023
Background Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life’s Essential 8 (LE8), a currently updated measure of cardiovascular health (CVH), and biological ageing.
Ronghuai Zhang, Min Wu, Wei Zhang, Xuna Liu, Jie Pu, Tao Wei, Zhanfang Zhu, Zhiguo Tang, Na Wei, Bo Liu, Qianwei Cui, Junkui Wang, Fuqiang Liu, Ying Lv   +13 more
doaj   +1 more source