Results 21 to 30 of about 5,699,048 (257)

Phenotypic age acceleration: a novel biomarker associated with increased risk of metabolic dysfunction-associated fatty liver disease [PDF]

Nutrition & Metabolism
Background Metabolic dysfunction-associated fatty liver disease (MAFLD) poses a growing public health challenge, but traditional metabolic markers may not fully capture individual risk, especially in individuals with normal metabolic phenotypes ...
Fangfei Xie, Yu’e Shen, Jing Zhao, Xunzhi Geng, Nimei Zeng, Renfang Han, Yi Wang, Yun Wang, Wenbin Xu, Jingyi Fan   +9 more
doaj   +2 more sources

Associations of sleeping, sedentary and physical activity with phenotypic age acceleration: a cross-sectional isotemporal substitution model [PDF]

BMC Geriatrics, 2023
Background Physical activity was believed to be associated with reduced aging among adults, while the competing nature of the physical activity and sedentary behavior has mainly been neglected in studies. We aimed to estimate the association of sleeping,
Mengying Han, Jiaxin Fang, Yixin Zhang, Xingxu Song, Lina Jin, Yanan Ma   +5 more
doaj   +2 more sources

Association between dietary and behavioral-based oxidative balance score and phenotypic age acceleration: a cross-sectional study of Americans [PDF]

Epidemiology and Health
OBJECTIVES In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging.
Dongzhe Wu, Yulin Shen, Chaoyi Qu, Peng Huang, Xue Geng, Jianhong Zhang, Zhijian Rao, Qiangman Wei, Shijie Liu, Jiexiu Zhao   +9 more
doaj   +2 more sources

The associations between the energy and timing of sugar-sweetened beverage intake and phenotypic age acceleration in U.S. adults: a cross-sectional survey of NHANES 2007–2010 [PDF]

BMC Public Health
Objectives The relationship between sugar-sweetened beverage (SSB) intake and phenotypic age acceleration (PhenoAgeAccel) is unclear. The aim of this study was to explore the associations between the energy and timing of SSB intake and PhenoAgeAccel in ...
Teng Xia, Qian Yuan, Yao Zhang, Guangmei Shan   +3 more
doaj   +2 more sources

Phenotypic Age Acceleration as a Mediator in Thyroid Hormone–Related Cardiovascular Risk Among the Elderly [PDF]

Cardiology Research and Practice
Minmin Wen, Yanjun Hou, Kaijia Shi, Jiaxin Zuo, Cheng Zhang, Shuya Zhang, Zhihua Shen, Wei Jie   +7 more
doaj   +2 more sources

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice [PDF]

Free Radical Biology and Medicine, 2013
Dietary restriction is a powerful aging intervention that extends the life span of diverse biological species ranging from yeast to invertebrates to mammals, and it has been argued that the antiaging action of dietary restriction occurs through reduced oxidative stress/damage.
Yiqiang, Zhang, Yuji, Ikeno, Alex, Bokov, Jon, Gelfond, Carlos, Jaramillo, Hong-Mei, Zhang, Yuhong, Liu, Wenbo, Qi, Gene, Hubbard, Arlan, Richardson, Holly, Van Remmen   +10 more
openaire   +2 more sources

U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study

BMC Geriatrics, 2023
Background Phenotypic age acceleration, which reflects the difference between phenotypic age and chronological age, is an assessment to measure accelerated aging.
Heng Li, Shuai Miao, Min Zhang, Peng Zhang, Yan-Bin Li, Rui-Sheng Duan   +5 more
doaj   +1 more source

BMI Mediates the Association between Macronutrient Subtypes and Phenotypic Age Acceleration. [PDF]

Nutrients
Background: There is growing evidence that diet and aging are associated; however, few studies have examined the relationship between macronutrient subtypes and phenotypic age acceleration, and the extent to which BMI (body mass index) mediates this association is unclear. Methods: This study included 6911 individuals who were 20 years or older and had
He K, Xu T, Song X, Fang J, Jiang K, Hu C, He X, Tao Y, Jin L.   +8 more
europepmc   +3 more sources

Systematic Analysis of Molecular and Cellular Dysfunction in Accelerated Aging Phenotypes [PDF]

, 2022
Accelerated aging in multiple tissues is the connecting characteristic of the group of genetic disorders called segmental progeroid syndromes. At young ages, affected patients show many clinical features of aging-associated pathologies such as hair graying, lipodystrophy, osteoporosis, cataracts, hearing loss, arteriosclerosis, diabetes mellitus, and ...
Werner, Gesa, Wollnik, Bernd, Wollnik, Bernd, Georg-August-Universität Göttingen, Wollnik, Bernd, Rehling, Peter   +5 more
openaire   +2 more sources

COGNITIVE AND NEURAL MECHANISMS OF THE ACCELERATED AGING PHENOTYPE IN PTSD [PDF]

The American Journal of Geriatric Psychiatry, 2019
Introduction Posttraumatic Stress Disorder (PTSD) affects 6.8% of adults in the United States and is associated with high rates of disability, comorbid medical and psychiatric disorders, and suicide. Older adults make up an increasingly large proportion of PTSD patients as the population skews older and Veterans from recent conflicts age.
Madeline Friedman, Chloe Salzman, Yuval Neria, Scott Small, Adam Brickman, Adam Ciarleglio, Frank Provenzano, Rachel Yehuda, Janine Flory, Philip Szeszko, Bret Rutherford   +10 more
openaire   +1 more source