Results 11 to 20 of about 5,699,048 (257)

The mediating role of insulin resistance in depression driving phenotypic age acceleration [PDF]

Annals of General Psychiatry
Background Depression, characterized by significant psychological and physiological alterations, has been proved to tightly associate with insulin resistance (IR) and hallmarks of biological aging.
Li Zhang, QianKun Yang, Jie Yu, Yue Hu
doaj   +5 more sources

Association of phenotypic age acceleration with all-cause and cause-specific mortality among U.S. cancer survivors: a retrospective cohort study [PDF]

BMC Cancer
Background Cancer survivors may experience accelerated biological aging, increasing their risk of mortality. However, the association between phenotypic age acceleration (PAA) and mortality among cancer survivors remains unclear.
Xiaoqiang Liu, Yubin Wang, Yingxuan Huang, Chanchan Lin, Boming Xu, Yilin Zeng, Peizhong Chen, Xiaobo Liu, Yisen Huang   +8 more
doaj   +3 more sources

Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration: The Veterans Affairs Normative Aging Study [PDF]

International Journal of Environmental Research and Public Health, 2019
DNA methylation may play a critical role in aging and age-related diseases. DNA methylation phenotypic age (DNAmPhenoAge) is a new aging biomarker and predictor of chronic disease risk.
Joel Schwartz, Cuicui Wang
exaly   +3 more sources

Phenotypic age acceleration as a novel predictor of benign prostatic hyperplasia: a prospective cohort study [PDF]

GeroScience
Abstract This study aims to investigate the predictive value of combined phenotypic age and phenotypic age acceleration (PhenoAgeAccel) for benign prostatic hyperplasia (BPH) and develop a machine learning-based risk prediction model to inform precision prevention and clinical management strategies.
Xiongjun Ye
exaly   +4 more sources

Phenotypic age acceleration and genetic risk synergistically increase age-related eye disease risk in the UK Biobank [PDF]

Scientific Reports
To evaluate the independent and synergistic effects of phenotypic age acceleration (PhenoAgeAccel) and genetic risk on age-related eye diseases (AREDs). We analyzed 395,322 participants from the UK Biobank to assess the association between PhenoAgeAccel ...
Haoyu Yuan, Yuxiang Hu
doaj   +2 more sources

Associations of volatile organic compound exposure with phenotypic age acceleration and the synergistic interaction of dietary micronutrients [PDF]

The Journal of Nutrition, Health and Aging
Objective: This study assesses the association between exposure to volatile organic compounds (VOCs) and phenotypic age acceleration, and evaluates the potential synergistic interaction by dietary micronutrient intake.
Huanrui Zhang, Wen Tian, Guoxian Qi, Baosen Zhou, Yujiao Sun   +4 more
doaj   +2 more sources

Associations of phenotypic age acceleration, genetic risk, and lifestyle with chronic digestive diseases: A large-scale longitudinal cohort study [PDF]

The Journal of Nutrition, Health and Aging
Background: Phenotypic age acceleration (PhenoAgeAccel) is a promising biological aging metric, but its associations with chronic digestive disease risk are unclear.
Shuai Xiang, Yixuan Li, Yunlong Li, Shuzhe Xie, Chengfeng Wang, Xu Che, Yongxing Du   +6 more
doaj   +2 more sources

Association of a newly proposed dietary index for gut microbiota with phenotypic age acceleration: a cross-sectional study of NHANES 1999–2018 [PDF]

Journal of Health, Population and Nutrition
Background Aging is closely linked to chronic diseases, and gut microbiota plays a significant role in this process. The Dietary Index for Gut Microbiota (DI-GM), a novel tool reflecting the potential impact of diet on gut microbiota diversity, has an ...
Boming Xu, Yingxuan Huang, Yilin Zeng, Peizhong Chen, Yubin Wang, Xiaoqiang Liu   +5 more
doaj   +2 more sources

Phenotypic age acceleration and all-cause and cardiovascular mortality among U.S. adults at risk for heart failure [PDF]

American Heart Journal Plus
Objective: To examine the associations of phenotypic age acceleration (PAA) with all-cause and cardiovascular mortality among U.S. adults at risk for heart failure.
Huifang Su, Xiandong Liu
doaj   +2 more sources

Biological aging matters: a cross-sectional study uncovering the association between phenotypic age acceleration and erectile dysfunction based on 2360 male individuals

The Aging Male
Background The current study aimed to explore the potential associations between Phenotypic Age (PhenoAge)/PhenoAge acceleration (PhenoAgeAccel) and erectile dysfunction (ED).Methods We carried out a cross-sectional study based on data from 2360 male ...
Fan Dong, Ping Ping, Yi Ma, Xiang-Feng Chen   +3 more
doaj   +3 more sources