Results 41 to 50 of about 5,699,048 (257)
iScience, 2023 Aging is characterized by progressive decline in tissue function and represents the greatest risk factor for many diseases. Nevertheless, many fundamental mechanisms driving human aging remain poorly understood. Aging studies using model organisms are often limited in their applicability to humans.
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The X-chromosome instability phenotype in Alzheimer’s disease: A clinical sign of accelerating aging? [PDF]
Medical Hypotheses, 2009 Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD).
Bajić, Vladan +7 more
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eClinicalMedicine, 2022 Accelerated aging leads to increasing burdens of chronic diseases in late life, posing a huge challenge to the society. With two well-developed aging measures (i.e., physiological dysregulation [PD] and frailty index [FI]), this study aimed to evaluate the relative contributions of life course circumstances (e.g., childhood and adulthood socioeconomic ...
Xingqi Cao +9 more
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Phenotypic flexibility and the evolution of organismal design [PDF]
, 2003 Evolutionary biologists often use phenotypic differences between species and between individuals to gain an understanding of organismal design. The focus of much recent attention has been on developmental plasticity – the environmentally induced ...
Piersma, T +4 more
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Photon acceleration in vacuum [PDF]
, 2006 A new process associated with the nonlinear optical properties of the electromagnetic vacuum, as predicted by quantum electrodynamics, is described. This can be called photon acceleration in vacuum, and corresponds to the frequency shift that takes place
Mendonça, J.T. +3 more
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Association of longitudinal body mass index trajectories with phenotypic age acceleration: a cross-sectional study based on growth mixture modeling [PDF]
GeroScienceYalan Liu, He Li
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ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse [PDF]
Cell Cycle, 2006 p63 is highly expressed in the skin and appears to be an early marker of keratinocyte differentiation. To examine the role of p63 in vivo, we generated transgenic mice that overexpress deltaNp63alpha in the skin. These mice exhibited an accelerated aging phenotype in the skin characterized by striking wound healing defects, decreased skin thickness ...
Matthias, Sommer +6 more
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Vertical evolution of auroral acceleration at substorm onset [PDF]
, 2009 This study describes the onset process of auroral substorms in connection with the vertical evolution of auroral particle acceleration, on the basis of auroral kilometric radiation (AKR) dynamics.
Morioka, A. +17 more
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Biology, 2022 Abstract We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardio-metabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, n = 306; aged 45-69 years).
Olga Chervova +13 more
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Solar flare particle acceleration in collapsing magnetic traps [PDF]
, 2012 Electronic redacted version excludes material for which permission has not been granted by the rights holderThe topic of this thesis is a detailed investigation of different aspects of the particle acceleration mechanisms operating in Collapsing Magnetic
Grady, Keith J.
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