Results 61 to 70 of about 5,699,048 (257)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Association of biological age acceleration with all-cause and cardiovascular mortality in HSV-positive adults: A population-based longitudinal cohort study.

PLoS ONE
BackgroundBiological age acceleration reflects physiological aging and its link to mortality in HSV-infected adults is unclear.MethodsWe analyzed data from 16,065 HSV-seropositive adults aged 20-59 years from the NHANES 1999-2016 cycles (mean age: 35.4 ± 
Jun Wei, Yuefeng Li, Yang Liu
doaj   +1 more source

Associations between dietary patterns and the incidence of idiopathic pulmonary fibrosis: A cohort study

The Journal of Nutrition, Health and Aging
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive, age-related lung disease with few modifiable risk factors. While healthy dietary patterns have been associated with reduced risk of chronic diseases, their impact on IPF remains unclear ...
Yonghao Li, Xinran Dou, Hui Li, Xuan Li, Luqin Yang, Jiawei Chen, Fengqin Zhang, Huihui Yue, Ruihan Dong, Jianhan He, Xuewen Wang, Wei Wei, Li Liu, Huilan Zhang   +13 more
doaj   +1 more source

Life course circumstances contribute to the acceleration of phenotypic and functional aging in Chinese middle-aged and older adults [PDF]

, 2021
Abstract Accelerated aging implies health inequalities in late life and consequently, poses a huge challenge to society. With two well-validated aging measures, this study aimed to evaluate the relative contributions of life course circumstances to variance in these aging measures with policy implications.
Xingqi Cao, Chao Ma, Zhoutao Zheng, Liu He, Meng Hao, Xi Chen, Eileen M. Crimmins, Thomas M. Gill, Morgan E. Levine, Zuyun Liu   +9 more
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Association of phenotypic age and accelerated aging with severity and disability in patients with acute ischemic stroke

The Journal of nutrition, health and aging
Biological age may be more accurate than chronological age in determining chronic health outcomes. However, few studies have shown the association between biological age and acute ischemic stroke (AIS). In this study we showed the association between phenotypic age (PhenoAge) or accelerated aging and severity and disability in patients with AIS ...
Yongkang Liu, Jiangchuan Wang, Zicheng Wei, Yu Wang, Minghua Wu, Jianhua Wang, Xiao Chen, Rong Chen   +7 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank

The Journal of Nutrition, Health and Aging
Background: Biological age acceleration helps to identify the gap between an individual's actual aging level and chronological age. Whether biological age acceleration mediates the effect of lifestyle factors on the risk of digestive system cancers ...
Wei Huang, Suxin Zhang, Wenying Chen, Wenqing Wang, Ying Lin, Shineng Zhang, Fengting Huang   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dietary diversity contributes to delay biological aging

Frontiers in Medicine
AimsAs aging is a major risk factor for chronic diseases, strategies to promote healthy aging are essential. Dietary diversity has been reported to be beneficial for human health, however, the role in the biological aging process remains underexplored ...
Wen Liao, Meng-ying Li
doaj   +1 more source