Results 91 to 100 of about 6,040 (161)

Phenome‐wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers

Cancer Medicine
Background Ovarian cancer (OC) is commonly diagnosed among older women who have comorbidities. This hypothesis‐free phenome‐wide association study (PheWAS) aimed to identify comorbidities associated with OC, as well as traits that share a genetic ...
Anwar Mulugeta, Amanda L. Lumsden, Iqbal Madakkatel, David Stacey, S. Hong Lee, Johanna Mäenpää, Martin K. Oehler, Elina Hyppönen   +7 more
doaj   +1 more source

Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study

Frontiers in Pharmacology
BackgroundThe relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.MethodsA two-sample
Yilong Lin, Yilong Lin, Yue Zhang, Songsong Wang, Lin Cao, Ruidan Zhao, Xilai Ma, Qiaolu Yang, Liyi Zhang, Qingmo Yang, Qingmo Yang   +10 more
doaj   +1 more source

Processing of Electronic Health Records using Deep Learning: A review

, 2018
Availability of large amount of clinical data is opening up new research avenues in a number of fields. An exciting field in this respect is healthcare, where secondary use of healthcare data is beginning to revolutionize healthcare.
Danieletto, Matteo, Dudley, Joel, Glicksberg, Benjamin, Li, Li, Mayora, Oscar, Osmani, Venet   +5 more
core  

Novel insights into the pleiotropic health effects of growth differentiation factor 11 gained from genome-wide association studies in population biobanks

BMC Genomics
Background Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β (TGF-β) superfamily that has gained considerable attention over the last decade for its observed ability to reverse age-related deterioration of multiple ...
Jessica Strosahl, Kaixiong Ye, Robert Pazdro   +2 more
doaj   +1 more source

Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population

Translational Psychiatry
Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development and progression are poorly understood.
Sarah M. C. Colbert, Lauren Lepow, Brian Fennessy, Nakao Iwata, Masashi Ikeda, Takeo Saito, Chikashi Terao, Michael Preuss, Jyotishman Pathak, J. John Mann, Hilary Coon, Niamh Mullins   +11 more
doaj   +1 more source

Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height

npj Genomic Medicine
We performed ancestry and sex specific Phenome Wide Association Studies (PheWAS) to explore disease related outcomes associated with genetically predicted height.
A. Papadopoulou, E. M. Litkowski, M. Graff, Z. Wang, R. A. J. Smit, G. Chittoor, I. Dinsmore, N. S. Josyula, M. Lin, J. Shortt, W. Zhu, S. L. Vedantam, L. Yengo, A. R. Wood, S. I. Berndt, I. A. Holm, F. D. Mentch, H. Hakonarson, K. Kiryluk, C. Weng, G. P. Jarvik, D. Crosslin, D. Carrell, I. J. Kullo, O. Dikilitas, M. G. Hayes, W. -Q. Wei, D. R. V. Edwards, T. L. Assimes, J. N. Hirschhorn, J. E. Below, C. R. Gignoux, A. E. Justice, R. J. F. Loos, Y. V. Sun, S. Raghavan, P. Deloukas, K. E. North, E. Marouli   +38 more
doaj   +1 more source

Extracting research-quality phenotypes from electronic health records to support precision medicine [PDF]

, 2015

core   +1 more source

A Method to Combine Signals from Spontaneous Reporting Systems and Observational Healthcare Data to Detect Adverse Drug Reactions [PDF]

, 2015

core   +1 more source

PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly. [PDF]

Curr Osteoporos Rep
Li S, Trajanoska K.
europepmc   +1 more source

Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response. [PDF]

Front Genet
Namjou B, Lape M, Weirauch MT, Kaufman KM, Kottyan LC.   +4 more
europepmc   +1 more source