Results 71 to 80 of about 6,310 (247)

Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study.

PLoS Genetics, 2014
We performed a Phenome-wide association study (PheWAS) utilizing diverse genotypic and phenotypic data existing across multiple populations in the National Health and Nutrition Examination Surveys (NHANES), conducted by the Centers for Disease Control ...
Molly A Hall, Anurag Verma, Kristin D Brown-Gentry, Robert Goodloe, Jonathan Boston, Sarah Wilson, Bob McClellan, Cara Sutcliffe, Holly H Dilks, Nila B Gillani, Hailing Jin, Ping Mayo, Melissa Allen, Nathalie Schnetz-Boutaud, Dana C Crawford, Marylyn D Ritchie, Sarah A Pendergrass   +16 more
doaj   +1 more source

netCRS: Network-based comorbidity risk score for prediction of myocardial infarction using biobank-scaled PheWAS data

bioRxiv, 2021
The polygenic risk score (PRS) can help to identify individuals’ genetic susceptibility for various diseases by combining patient genetic profiles and identified single-nucleotide polymorphisms (SNPs) from genome-wide association studies.
Yonghyun Nam, Sang-Hyuk Jung, A. Verma, V. Sriram, H. Won, Jae-Seung Yun, Dokyoon Kim   +6 more
semanticscholar   +1 more source

Results of the PheWAS using exact ICD-10 diagnosis codes and passing the PheWAS significance threshold.

, 2019
Results of the PheWAS using exact ICD-10 diagnosis codes and passing the PheWAS significance threshold.
A. Katrina Loomis (188711), Myriam Alexander (5622932), Nicholas Galwey (6585521), Liis Kolberg (5967164), Reedik Mägi (667294), Paul Avillach (173608), Dawn Waterworth (160856), Glen James (6585518), Sulev Reisberg (3139788), Jaak Vilo (231157), Kaido Lepik (4442437), Tõnu Esko (102379)   +11 more
core   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

B1_ALL" PRS PheWAS Meta-Analysis Results for EAS Ancestry, Adjusted for BMI.

, 2023
B1_ALL" PRS PheWAS Meta-Analysis Results for EAS Ancestry, Adjusted for BMI.
Ritoban Kundu (10937289), Stephen Burgess (3368630), Bhramar Mukherjee (90346), Maxwell Salvatore (6836702), Xu Shi (216330), Seunggeun Lee (741906), Lars G. Fritsche (9046596), Kisung Nam (17675388), Jiacong Du (12035845)   +8 more
core   +1 more source

Delivery mode and maternal health conditions before and after childbirth: A population‐based cohort study from Estonia

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Cesarean section is associated with higher rates of chronic health conditions and pregnancy‐related complications, whereas vaginal delivery is more commonly linked to pelvic floor and perineal complications. These findings emphasize the need for individualized decision‐making and thorough counseling about the risks and benefits of each delivery method.
Katrin Täär, Helle Karro, Merli Saare, Reedik Mägi, Estonian Biobank Research Team, Andres Metspalu, Lili Milani, Tõnu Esko, Mait Metspalu, Mari Nelis, Georgi Hudjashov, Andres Salumets, Triin Laisk, Maire Peters   +13 more
wiley   +1 more source

Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization.

PLoS Genetics, 2019
Mendelian randomization (MR) has been used to estimate the causal effect of body mass index (BMI) on particular traits thought to be affected by BMI. However, BMI may also be a modifiable, causal risk factor for outcomes where there is no prior reason to
Louise A C Millard, Neil M Davies, Kate Tilling, Tom R Gaunt, George Davey Smith   +4 more
doaj   +1 more source

A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans.

PLoS ONE, 2019
We performed a hypothesis-generating phenome-wide association study (PheWAS) to identify and characterize cross-phenotype associations, where one SNP is associated with two or more phenotypes, between thousands of genetic variants assayed on the ...
Sarah A Pendergrass, Steven Buyske, Janina M Jeff, Alex Frase, Scott Dudek, Yuki Bradford, Jose-Luis Ambite, Christy L Avery, Petra Buzkova, Ewa Deelman, Megan D Fesinmeyer, Christopher Haiman, Gerardo Heiss, Lucia A Hindorff, Chun-Nan Hsu, Rebecca D Jackson, Yi Lin, Loic Le Marchand, Tara C Matise, Kristine R Monroe, Larry Moreland, Kari E North, Sungshim L Park, Alex Reiner, Robert Wallace, Lynne R Wilkens, Charles Kooperberg, Marylyn D Ritchie, Dana C Crawford   +28 more
doaj   +1 more source

PheWAS Results for MPV, MCV and PC.

, 2019
PheWAS Results for MPV, MCV and PC.
William J. Metcalf (6837206), Gai Elhanan (6837203), Robert Borkowski (158187), Karen A. Schlauch (6837200), Anthony D. Slonim (6837209), Joseph J. Grzymski (564075), Robert W. Read (6248582), Ramsey Aweti (6837212)   +7 more
core   +1 more source

Cohort-specific "B2_ALL" PRS PheWAS Results for EUR Ancestry, Adjusted for BMI.

, 2023
Cohort-specific "B2_ALL" PRS PheWAS Results for EUR Ancestry, Adjusted for BMI.
Ritoban Kundu (10937289), Stephen Burgess (3368630), Bhramar Mukherjee (90346), Maxwell Salvatore (6836702), Xu Shi (216330), Seunggeun Lee (741906), Lars G. Fritsche (9046596), Kisung Nam (17675388), Jiacong Du (12035845)   +8 more
core   +1 more source