Results 71 to 80 of about 6,040 (161)

Association between borderline dysnatremia and mortality insight into a new data mining approach

BMC Medical Informatics and Decision Making, 2017
Background Even small variations of serum sodium concentration may be associated with mortality. Our objective was to confirm the impact of borderline dysnatremia for patients admitted to hospital on in-hospital mortality using real life care data from ...
Yannick Girardeau, Anne-Sophie Jannot, Gilles Chatellier, Olivier Saint-Jean   +3 more
doaj   +1 more source

Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings. [PDF]

, 2019
In order to advance precision medicine, detailed clinical features ought to be described in a way that leverages current knowledge. Although data collected from biomedical research is expanding at an almost exponential rate, our ability to transform that
Baranzini, Sergio E, Butte, Atul J, Nelson, Charlotte A   +2 more
core  

Disease networks identify specific conditions and pleiotropy influencing multimorbidity in the general population [PDF]

, 2018
Multimorbidity is an emerging topic in public health policy because of its increasing prevalence and socio-economic impact. However, the age- and gender-dependent trends of disease associations at fine resolution, and the underlying genetic factors ...
Amell, A., Comellas Padró, Francesc de Paula, Palomero, L., Roso Llorach, Albert   +3 more
core   +2 more sources

Heat transfer and pressure drop characteristics of a plate heat exchanger using water based Al2O3 nanofluid for 30° and 60° chevron angles [PDF]

, 2018
Nanofluid is a new class of engineering fluid that has good heat transfer characteristics which is essential to increase the heat transfer performance in various engineering applications such as heat exchangers and cooling of electronics.
Ben-Mansour, R, Elias, M. M, Hepbasli, A, Kaur, Jesbains *, Rahim, N. A, Saidur Rahman, *   +5 more
core   +1 more source

UK Biobank: Transforming drug discovery and precision medicine

British Journal of Pharmacology, Volume 183, Issue 2, Page 234-248, January 2026.
UK Biobank is a large‐scale, prospective study with extensive genetic and phenotypic data on half a million individuals. Volunteers, aged between 40 and 69 years, were recruited between 2006 and 2010 from the general population of the United Kingdom.
Jelena Bešević, Saredo Said, Reka Nagy, Yalda Jamshidi, Christopher D. Whelan, Lauren Carson, Martin K. Rutter, Adam J. Lewandowski, Mark Effingham, Rory Collins, Ben Lacey, Naomi E. Allen   +11 more
wiley   +1 more source

An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. [PDF]

, 2018
Despite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these undiagnosed disorders often have complex presentations and require treatment by multiple health care ...
Bjonnes, Andrew, Briere, Lauren C, Carmichael, Nikkola, Cassa, Christopher A, Chopra, Sameer S, Fay, Christopher J, Feldweg, Anna, Fieg, Elizabeth, Frank, Alexander, Frank, Natasha Y, Goessling, Wolfram, Green, Robert C, Gupta, Vandana A, Haghighi, Alireza, Hanna, Meredith, Klein, Ophir D, Kooshesh, Kameron, Krier, Joel B, Leshchiner, Ignaty, Liao, Eric, Lincoln, Sharyn, Loscalzo, Joseph, Lucia, Stephanie, Maas, Richard L, MacRae, Calum A, Mannstadt, Michael, Mohanty, Anwoy, Nowak, Catherine B, Ouahed, Jodie, Pantazi, Angeliki, Patsopoulos, Nikolaos A, Perroni, Victoria, Perry, Hazel, Qiu, Haiyan, Raychaudhuri, Soumya, Sanchez-Lara, Pedro A, Seidman, Christine E, Snapper, Scott B, Stitziel, Nathan O, Stoler, Joan M, Sunyaev, Shamil R, Sutti, Sheila, Sweetser, David A, Söylemez, Onuralp, Toth-Petroczy, Agnes, Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM), Valerius, Jamie, Vuzman, Dana   +47 more
core  

Genomic Structural Equation Modeling Combined With Post‐GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block

Genetics Research , Volume 2026, Issue 1, 2026.
Background Cardiac conduction disorders (CCDs) represent a broad spectrum of severe cardiovascular conditions associated with syncope and sudden cardiac death. Therefore, identification of reliable biomarkers is necessary to significantly improve the diagnostic accuracy and therapeutic outcomes of CCDs. This study analyzed GWAS summary datasets using a
Tongyu Wang, Xinge Miao, Yunlong Xia, Irfan Ahmad   +3 more
wiley   +1 more source

Genetic Association Between Sex Hormones, Serum Urate, and Gout: A Comprehensive Mendelian Randomization Study

International Journal of Endocrinology, Volume 2026, Issue 1, 2026.
Background Sex hormones have been associated with the risk of hyperuricemia (HUA) and gout in observational studies, but the potential causal relationships between sex hormones and risk of HUA and gout remain largely unclear. This study aimed to further investigate the mechanism underlying the causality between sex hormones, HUA, and gout in different ...
Shiwei Li, Mengjuan Zhang, Xuemei Wang, Yadi Huang, Bo Huang, Meng Wang, Ming Liu, Jingqiu Cui, Arturo Bevilacqua   +8 more
wiley   +1 more source

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium

Nature Communications
Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic indications or on ...
Ichcha Manipur, Guillermo Reales, Jae Hoon Sul, Myung Kyun Shin, Simonne Longerich, Adrian Cortes, Chris Wallace   +6 more
doaj   +1 more source

Causal Association Between Commonly Used Medicines and Diabetes‐Related Eye Diseases: Univariable and Multivariable Mendelian Randomization Study

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Background Diabetic patients require long‐term polypharmacy, yet the causal effects of these medications on ocular complications—specifically diabetic retinopathy (DR), diabetic maculopathy (DMac), and glaucoma—remain unclear due to confounding in observational studies.
Yu Wang, Chak Kwong Cheng, Lamusi A., Mingyue Jin, Chang Wang, Riccardo Calafiore   +5 more
wiley   +1 more source