Results 51 to 60 of about 3,687 (173)

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Med Research, Volume 2, Issue 2, Page 214-226, June 2026.
ABSTRACT Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory disorders. Data sources included the National Health and Nutrition Examination Survey (NHANES), UK
Haolong Zhou, Danyang Ling, Qin Huang, Jiaojun Liang, Guanhua Su, Zhangbo Cui, Ziwei Chen, Xiaowen Ma, Zhou Jiang, Shuo Zheng, Haodong Tian, Qi Wang   +11 more
wiley   +1 more source

Pharmacogenomics in the Age of GWAS, Omics Atlases, and PheWAS

, 2018
The search for causative pharmacogenomic loci is being transformed by integrative omics pipelines, but their outputs have only begun being applied to test design. We assess the direction of the field in light of Biobanks/PheWAS, omics atlases, and AI. We first assess the potential of recent epigenome and spatial genome concepts, datasets, and methods ...
Allyn-Feuer, Ari, Higgins, Gerald A., Athey, Brian D.   +2 more
openaire   +2 more sources

Phenome-wide association study in 25,639 pregnant Chinese women reveals loci associated with maternal comorbidities and child health

Cell Genomics
Summary: Phenome-wide association studies (PheWAS) have been less focused on maternal diseases and maternal-newborn comorbidities, especially in the Chinese population.
Jintao Guo, Qiwei Guo, Taoling Zhong, Chaoqun Xu, Zhongmin Xia, Hongkun Fang, Qinwei Chen, Ying Zhou, Jieqiong Xie, Dandan Jin, You Yang, Xin Wu, Huanhuan Zhu, Ailing Hour, Xin Jin, Yulin Zhou, Qiyuan Li   +16 more
doaj   +1 more source

Sex‐differential associations of MC3R p.F45S with human metabolic profile

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Obesity and related metabolic disorders represent major global health challenges, highlighting the importance of understanding the central regulation of energy homeostasis. The melanocortin system is a conserved circuitry governing food intake and other neuroendocrine processes.
Tanya C. Kaur, Andrew R. Wood, Gareth Hawkes, Robin N. Beaumont, Kartik Chundru, Michael N. Weedon, Hugh D. Piggins, Kate L. J. Ellacott   +7 more
wiley   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

Arthritis Care &Research, Volume 78, Issue 5, Page 662-669, May 2026.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung, John P. Shelley, Gul Karakoc, John Still, Xiaodi Ruan, Jonathan Mosley, C. Michael Stein, Vivian K. Kawai   +7 more
wiley   +1 more source

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank [PDF]

PLOS Genetics, 2019
ABSTRACT Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric disease risk can be a useful alternative for research questions that would traditionally require large ...
Beate Leppert, Louise A. C. Millard, Lucy Riglin, George Davey Smith, Anita Thapar, Kate Tilling, Esther Walton, Evie Stergiakouli   +7 more
openaire   +8 more sources

Systems genetic validation of the SNP-metabolite association in rice via metabolite-pathway-based phenome-wide association scans

Frontiers in Plant Science, 2015
In the post-GWAS (Genome-Wide Association Scan) era, the interpretation of GWAS results is crucial to screen for highly relevant phenotype-genotype association pairs.
Yaping eLu, Yemao eLiu, Xiaohui eNiu, Qingyong eYang, Xuehai eHu, Hong-Yu eZhang, Jingbo eXia   +6 more
doaj   +1 more source

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort

PLOS ONE, 2018
Abstract In this study, we perform a full genome-wide association study (GWAS) to identify statistically significantly associated single nucleotide polymorphisms (SNPs) with three red blood cell (RBC) components and follow it with two independent PheWASs to examine associations between phenotypic data (case-control ...
Robert W. Read, Karen A. Schlauch, Gai Elhanan, William J. Metcalf, Anthony D. Slonim, Ramsey Aweti, Robert Borkowski, Joseph J. Grzymski   +7 more
openaire   +5 more sources

Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections.

PLoS ONE
BackgroundPhenome-Wide Association study (PheWAS) is a powerful tool designed to systematically screen clinical observations derived from medical records (phenotypes) for association with a variable of interest.
Patrick Allaire, Noha S Elsayed, Richard L Berg, Warren Rose, Sanjay K Shukla   +4 more
doaj   +1 more source

PARTICIPATORY GIS FOR SOIL CONSERVATION IN PHEWA WATERSHED OF NEPAL [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2012
Abstract. Participatory Geographic Information Systems (PGIS) can integrate participatory methodologies with geo-spatial technologies for the representation of characteristic of particular place. Over the last decade, researchers use this method to integrate the local knowledge of community within a GIS and Society conceptual framework.
openaire   +3 more sources