Results 51 to 60 of about 6,310 (247)

Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies

EBioMedicine, 2022
Summary: Background: Calcium plays a role in a wide range of biological functions. Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects of ...
Shuai Yuan, Lili Yu, Wanglong Gou, Lijuan Wang, Jing Sun, Doudou Li, Ying Lu, Xiaxia Cai, Huanling Yu, Changzheng Yuan, Ju-sheng Zheng, Susanna C. Larsson, Evropi Theodoratou, Xue Li   +13 more
doaj   +1 more source

"B1_ALL" PRS PheWAS Meta-Analysis Results for EAS Ancestry, Unadjusted for BMI.

, 2023
"B1_ALL" PRS PheWAS Meta-Analysis Results for EAS Ancestry, Unadjusted for BMI.
Ritoban Kundu (10937289), Stephen Burgess (3368630), Bhramar Mukherjee (90346), Maxwell Salvatore (6836702), Xu Shi (216330), Seunggeun Lee (741906), Lars G. Fritsche (9046596), Kisung Nam (17675388), Jiacong Du (12035845)   +8 more
core   +1 more source

Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network.

PLoS Genetics, 2013
Using a phenome-wide association study (PheWAS) approach, we comprehensively tested genetic variants for association with phenotypes available for 70,061 study participants in the Population Architecture using Genomics and Epidemiology (PAGE) network ...
Sarah A Pendergrass, Kristin Brown-Gentry, Scott Dudek, Alex Frase, Eric S Torstenson, Robert Goodloe, Jose Luis Ambite, Christy L Avery, Steve Buyske, Petra Bůžková, Ewa Deelman, Megan D Fesinmeyer, Christopher A Haiman, Gerardo Heiss, Lucia A Hindorff, Chu-Nan Hsu, Rebecca D Jackson, Charles Kooperberg, Loic Le Marchand, Yi Lin, Tara C Matise, Kristine R Monroe, Larry Moreland, Sungshim L Park, Alex Reiner, Robert Wallace, Lynn R Wilkens, Dana C Crawford, Marylyn D Ritchie   +28 more
doaj   +1 more source

BIGwas: Single-command quality control and association testing for multi-cohort and biobank-scale GWAS/PheWAS data

GigaScience, 2021
Background Genome-wide association studies (GWAS) and phenome-wide association studies (PheWAS) involving 1 million GWAS samples from dozens of population-based biobanks present a considerable computational challenge and are carried out by large ...
J. Kässens, L. Wienbrandt, D. Ellinghaus   +2 more
semanticscholar   +1 more source

PYPE: A Python pipeline for phenome-wide association (PheWAS) and mendelian randomization in investigator-driven phenotypes and genotypes of biobank data

bioRxiv, 2022
Motivation Phenome-wide association studies (PheWASs) serve as a way of documenting the relationship between genotypes and multiple phenotypes, helping to uncover new and unexplored genotype-phenotype associations (known as pleiotropy).
Taykhoom Dalal, C. Patel
semanticscholar   +1 more source

B2_ALL" PRS PheWAS Meta-Analysis Results for EUR Ancestry, Adjusted for BMI.

, 2023
B2_ALL" PRS PheWAS Meta-Analysis Results for EUR Ancestry, Adjusted for BMI.
Ritoban Kundu (10937289), Stephen Burgess (3368630), Bhramar Mukherjee (90346), Maxwell Salvatore (6836702), Xu Shi (216330), Seunggeun Lee (741906), Lars G. Fritsche (9046596), Kisung Nam (17675388), Jiacong Du (12035845)   +8 more
core   +1 more source

An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

Genome Medicine, 2018
Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear.
Junfei Zhao, Feixiong Cheng, Peilin Jia, Nancy Cox, Joshua C. Denny, Zhongming Zhao   +5 more
doaj   +1 more source

Predictive models for abdominal aortic aneurysms using polygenic scores and PheWAS-derived risk factors

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2022
Abdominal aortic aneurysms (AAA) are common enlargements of the abdominal aorta which can grow larger until rupture, often leading to death. Detection of AAA is often by ultrasonography and screening recommendations are mostly directed at men over 65 ...
J. Hellwege, Chad Dorn, M. Irvin, N. Limdi, J. Cimino, T. Beasley, Philip S. Tsao, S. Damrauer, D. Roden, D. Velez Edwards, Wei-Qi Wei, T. Edwards   +11 more
semanticscholar   +1 more source

Results of the PheWAS using the PheWAS codes and passing the PheWAS significance threshold.

, 2019
Results of the PheWAS using the PheWAS codes and passing the PheWAS significance threshold.
A. Katrina Loomis (188711), Myriam Alexander (5622932), Nicholas Galwey (6585521), Liis Kolberg (5967164), Reedik Mägi (667294), Paul Avillach (173608), Dawn Waterworth (160856), Glen James (6585518), Sulev Reisberg (3139788), Jaak Vilo (231157), Kaido Lepik (4442437), Tõnu Esko (102379)   +11 more
core   +1 more source

Cohort-specific "B1_ALL" PRS PheWAS Results for EUR Ancestry, Unadjusted for BMI.

, 2023
Cohort-specific "B1_ALL" PRS PheWAS Results for EUR Ancestry, Unadjusted for BMI.
Ritoban Kundu (10937289), Stephen Burgess (3368630), Bhramar Mukherjee (90346), Maxwell Salvatore (6836702), Xu Shi (216330), Seunggeun Lee (741906), Lars G. Fritsche (9046596), Kisung Nam (17675388), Jiacong Du (12035845)   +8 more
core   +1 more source