Results 61 to 70 of about 6,040 (161)

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms [PDF]

, 2016
Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based Estonian Biobank using high-coverage
Buenrostro, Jason D., Chiarle, Roberto, Esko, Tonu, Fischer, Krista, Gabriel, Stacey B., Guo, Michael H., Hirschhorn, Joel N., Kals, Mart, Kathiresan, Sekar, Lander, Eric S., Magi, Reedik, Metspalu, Andres, Milani, Lili, Mitt, Mario, Nandakumar, Satish K., Natarajan, Pradeep, Palta, Priit, Pärn, Kalle, Salem, Rany M., Sankaran, Vijay G., Ulirsch, Jacob C., Zekavat, Seyedeh M.   +21 more
core   +2 more sources

A Narrative Review of Gene‐Environment Interactions in Pediatric Pulmonology

Pediatric Pulmonology, Volume 61, Issue 3, March 2026.
ABSTRACT Genetic and environmental factors are known to shape the onset, course, and outcomes of pediatric lung disease, yet interactions between these variables are rarely considered in clinical practice. Gene‐environment (GxE) interactions occur when the combined effect of a genetic variant and an environmental exposure differs from what would be ...
Jelte Kelchtermans
wiley   +1 more source

Phenome-wide association study in 25,639 pregnant Chinese women reveals loci associated with maternal comorbidities and child health

Cell Genomics
Summary: Phenome-wide association studies (PheWAS) have been less focused on maternal diseases and maternal-newborn comorbidities, especially in the Chinese population.
Jintao Guo, Qiwei Guo, Taoling Zhong, Chaoqun Xu, Zhongmin Xia, Hongkun Fang, Qinwei Chen, Ying Zhou, Jieqiong Xie, Dandan Jin, You Yang, Xin Wu, Huanhuan Zhu, Ailing Hour, Xin Jin, Yulin Zhou, Qiyuan Li   +16 more
doaj   +1 more source

Exonic Variation in HLA‐C, CFB, and TAP2 Associated With Increased Risk for Comorbid Crohn's Disease and Psoriasis

International Journal of Dermatology, Volume 65, Issue 3, Page 553-562, March 2026.
Our recent work established an association between high polygenic risk scores (PRSes) for both psoriasis and Crohn's disease with the development of comorbid disease. The protein‐coding genetic variation associated with the development of comorbid psoriasis and Crohn's disease is understudied.
Vikram R. Shaw, Jinyoung Byun, Catherine Zhu, Jared Sninsky, Younghun Han, Jeffrey M. Cohen, Christopher I. Amos   +6 more
wiley   +1 more source

PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology [PDF]

, 2017
Integrative Gene-set, Network and Pathway Analysis (GNPA) is a powerful data analysis approach developed to help interpret high-throughput omics data. In PAGER 1.0, we demonstrated that researchers can gain unbiased and reproducible biological insights ...
Chen, Jake Y., Neylon, Michael T., Shin, Jimin, Tan, Aik Choon, Yoo, Minjae, Yue, Zongliang, Zhao, Zhiying, Zheng, Qi   +7 more
core   +1 more source

Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Neuroimaging genetics has advanced our understanding of Alzheimer's disease (AD); however, frameworks using functional genomics are needed to elucidate mechanisms connecting loci to neurological outcomes. To address this need, we explored relationships between AD‐associated variants and disease via their impact on gene expression ...
Xavier Bledsoe, Ting‐Chen Wang, Yiyang Wu, Derek Archer, Hung Hsin Chen, Adam C. Naj, William S. Bush, Timothy J. Hohman, Logan Dumitrescu, Jennifer E. Below, Eric R. Gamazon   +10 more
wiley   +1 more source

Systems genetic validation of the SNP-metabolite association in rice via metabolite-pathway-based phenome-wide association scans

Frontiers in Plant Science, 2015
In the post-GWAS (Genome-Wide Association Scan) era, the interpretation of GWAS results is crucial to screen for highly relevant phenotype-genotype association pairs.
Yaping eLu, Yemao eLiu, Xiaohui eNiu, Qingyong eYang, Xuehai eHu, Hong-Yu eZhang, Jingbo eXia   +6 more
doaj   +1 more source

Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections.

PLoS ONE
BackgroundPhenome-Wide Association study (PheWAS) is a powerful tool designed to systematically screen clinical observations derived from medical records (phenotypes) for association with a variable of interest.
Patrick Allaire, Noha S Elsayed, Richard L Berg, Warren Rose, Sanjay K Shukla   +4 more
doaj   +1 more source

Assessment of Arthrobacter viscosus as reactive medium for forming permeable reactive biobarrier applied to PAHs remediation [PDF]

, 2013
Polycyclic aromatic hydrocarbons (PAHs) are significant environmental contaminants as they are present naturally as well as anthropogenically in soil, air and water.
A Tiehm, AK Haritash, AN Mabbett, C Karigar, C Quintelas, C Quintelas, C Raghukumar, D Çetin, E López, E Manoli, E Rosales, F Costa, F Moscoso, F Moscoso, G Blázquez, G Rytwo, GM Zaitsev, H Peng, J He, K Furukawa, L. Ferreira, M Nadal, M Pazos, M. A. Sanromán, M. Cobas, M. Pazos, MIM Ferreira, MT Alcántara, OB Akpor, R Thiruvenkatachari, RH Peng, S Kocaoba, S Lameiras, S Saponaro, SK Samanta, SM Bamforth, T Srinath, T. Tavares, U Sack   +38 more
core   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, Volume 7, Issue 1, January 2026.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source