Results 41 to 50 of about 6,093 (247)
Health effects of milk consumption: phenome-wide Mendelian randomization study
BMC Medicine, 2022 Background We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population.
Shuai Yuan +9 more
doaj +1 more source
Bioinform., 2022 Motivation Understanding comorbidity is essential for disease prevention, treatment and prognosis. In particular, insight into which pairs of diseases are likely or unlikely to co-occur may help elucidate the potential relationships between complex ...
Yonghyun Nam +10 more
semanticscholar +1 more source
, 2022 Additional file 2: Table S1. A list of 56 genes and the associated medical conditions recommended by ACMG for return of results. Table S2. The full list of the extracted PheCodes and the corresponding prevalences among the 15,181 individuals analyzed in
Scott T. Weiss (6956660) +9 more
core +1 more source
EBioMedicine, 2020 Background: The three main alleles of the APOE gene (ε4, ε3 and ε2) carry differential risks for conditions including Alzheimer's disease (AD) and cardiovascular disease.
Amanda L. Lumsden +3 more
doaj +1 more source
Overview of variant selection and PheWAS analysis design.
, 2022 Overview of variant selection and PheWAS analysis design.
Hongyu Zhao (4728) +35 more
core +1 more source
Large-Scale Simultaneous Testing of Cross-Covariance Matrices with Applications to PheWAS [PDF]
Statistica Sinica, 2019 Motivated by applications in phenome-wide association studies (PheWAS), we consider in this paper simultaneous testing of columns of high-dimensional cross-covariance matrices and develop a multiple testing procedure with theoretical guarantees. It is shown that the proposed testing procedure maintains a desired false discovery rate (FDR) and false ...
Cai, Tianxi +3 more
openaire +3 more sources
EBioMedicine, 2022 Summary: Background: Calcium plays a role in a wide range of biological functions. Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects of ...
Shuai Yuan +13 more
doaj +1 more source
medRxiv, 2022 Summary: Deep-PheWAS is a platform for phenome wide association studies that creates clinically-curated composite phenotypes, and integrates quantitative phenotypes from primary care data, longitudinal trajectories of quantitative measures, disease ...
R. Packer +13 more
semanticscholar +1 more source
Forest plot of PheWAS analyses of hospitalised COVID-19 risk.
, 2021 Forest plot of PheWAS analyses of hospitalised COVID-19 risk.
Hanan Musa (11383838) +5 more
core +1 more source
Joint mouse–human phenome-wide association to test gene function and disease risk
Nature Communications, 2016 Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to ...
Xusheng Wang +25 more
doaj +1 more source