Results 21 to 30 of about 6,040 (161)
Inference for High-dimensional Differential Correlation Matrices [PDF]
, 2015 Motivated by differential co-expression analysis in genomics, we consider in this paper estimation and testing of high-dimensional differential correlation matrices.
Cai, T. Tony, Zhang, Anru
core +3 more sources
HCLC-FC: A novel statistical method for phenome-wide association studies.
PLoS ONE, 2022 The emergence of genetic data coupled to longitudinal electronic medical records (EMRs) offers the possibility of phenome-wide association studies (PheWAS).
Xiaoyu Liang +3 more
doaj +1 more source
MR-PheWAS:Hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization [PDF]
, 2015 Observational cohort studies can provide rich datasets with a diverse range of phenotypic variables. However, hypothesis-driven epidemiological analyses by definition only test particular hypotheses chosen by researchers.
Davey Smith, George +5 more
core +2 more sources
Pretreatment cognitive and neural differences between sapropterin dihydrochloride responders and non-responders with phenylketonuria [PDF]
, 2017 Sapropterin dihydrochloride (BH4) reduces phenylalanine (Phe) levels and improves white matter integrity in a subset of individuals with phenylketonuria (PKU) known as “responders.” Although prior research has identified biochemical and genotypic ...
Christ, Shawn E +5 more
core +4 more sources
A simulation study investigating power estimates in phenome-wide association studies
BMC Bioinformatics, 2018 Background Phenome-wide association studies (PheWAS) are a high-throughput approach to evaluate comprehensive associations between genetic variants and a wide range of phenotypic measures.
Anurag Verma +6 more
doaj +1 more source
EBioMedicine, 2020 Background: The three main alleles of the APOE gene (ε4, ε3 and ε2) carry differential risks for conditions including Alzheimer's disease (AD) and cardiovascular disease.
Amanda L. Lumsden +3 more
doaj +1 more source
Health effects of milk consumption: phenome-wide Mendelian randomization study
BMC Medicine, 2022 Background We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population.
Shuai Yuan +9 more
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Calcium plays a role in a wide range of biological functions. Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects of ...
Shuai Yuan +13 more
doaj +1 more source
Joint mouse–human phenome-wide association to test gene function and disease risk
Nature Communications, 2016 Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to ...
Xusheng Wang +25 more
doaj +1 more source
Environment International, 2019 The field of environmental epidemiology has been using “-omics” technologies, including the exposome, metabolome, and methylome, to understand the potential effects and biological pathways of a number of environmental pollutants. However, the majority of
Joseph M. Braun +3 more
doaj +1 more source