Results 21 to 30 of about 6,093 (247)
Integrated Genome-Wide Association Studies and Selection Signature Analysis Reveal the Genetic Architecture of the Wattle Trait in Goats. [PDF]
Anim GenetABSTRACT Wattles are finger‐like appendages on the ventral neck of goats, serving as a distinctive morphological marker for breed identification that serves potential implications for production performance. However, their genetic basis remains incompletely characterized.
Hu S, Wei C, Feng D, Gan S.
europepmc +2 more sources
A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank [PDF]
PLOS Genetics, 2019 Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric disease risk can be a useful ...
B. Leppert +7 more
semanticscholar +9 more sources
eLife, 2023 Background: Whether natural selection may have attributed to the observed blood group frequency differences between populations remains debatable. The ABO system has been associated with several diseases and recently also with susceptibility to COVID-19 ...
Peter Bruun-Rasmussen +4 more
doaj +1 more source
PheWAS-ME: a web-app for interactive exploration of multimorbidity patterns in PheWAS [PDF]
Bioinformatics, 2019 Abstract Summary Electronic health records (EHRs) linked with a DNA biobank provide unprecedented opportunities for biomedical research in precision medicine. The Phenome-wide association study (PheWAS) is a widely used technique for the evaluation of relationships between genetic variants and ...
Nick Strayer +5 more
openaire +3 more sources
Scientific Reports, 2022 The expanding use of the phenome-wide association study (PheWAS) faces challenges in the context of using International Classification of Diseases billing codes for phenotype definition, imbalanced study population ethnicity, and constrained application ...
Eun Kyung Choe +6 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2020 The aggregation of Electronic Health Records (EHR) and personalized genetics leads to powerful discoveries relevant to population health. Here we perform genome-wide association studies (GWAS) and accompanying phenome-wide association studies (PheWAS) to
Karen A. Schlauch +7 more
doaj +1 more source
ExPheWas: a browser for gene-based pheWAS associations [PDF]
, 2021 Structured Abstract Motivation The relationship between protein coding genes and phenotypes has the potential to inform on the underlying molecular function in disease etiology. We conducted a phenome-wide association study (pheWAS) of protein coding genes using a principal components analysis-based ...
Marc-André Legault +2 more
openaire +1 more source
Landslide Susceptibility Mapping of Phewa Watershed, Kaski, Nepal
Mathematical Models in Engineering, 2023 Abstract The objective of this study was to assess the quantities of association between landslide events and causal factors in order to generate an accurate, updated landslide susceptibility map (LSM) of the Phewa watershed in Kaski, Gandaki District, Nepal.
Bimal Bahadur Kunwar +3 more
openaire +1 more source
medRxiv, 2023 Mendelian Randomisation (MR) is a statistical method that estimates causal effects between risk factors and common complex diseases using genetic instruments.
L. Darrous +3 more
semanticscholar +1 more source
Realising the full potential of MR-PHeWAS in cancer [PDF]
British Journal of Cancer, 2020 SummaryMR-PHeWAS is a powerful new design for discovering causal mechanisms between a disease and its many candidate risk factors in a hypothesis-free manner. This technique has great potential in the field of cancer research, provided that both powerful and principled statistical approaches are used.
openaire +2 more sources