Results 21 to 30 of about 6,310 (247)

MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent

iScience, 2021
Summary: Magnesium is integral to many physiological processes, whereas variations in its levels, even within the normal range, can have critical implications for health.
Longman Li, Wenjun Yang, Lulu Huang, Xiuming Feng, Hong Cheng, Xiaoting Ge, Gaohui Zan, Yanli Tan, Lili Xiao, Chaoqun Liu, Xing Chen, Zengnan Mo, Xiaobo Yang   +12 more
doaj   +2 more sources

Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome-Wide Association Studies. [PDF]

Genet Epidemiol
ABSTRACT Most Mendelian randomization (MR) of dietary intake use the full set of genome‐wide significant (GWS) variants in the instrumental variable (IV), likely biasing causal estimates due to pleiotropy. To characterize the common methods to handle pleiotropy in dietary intake MR, we conducted a scoping review of the literature on dietary intake MR ...
Sutton KJ, Gervis JE, Jatoi M, Hwang LD, Hendricks AE, Ghosh D, Westerman KE, Cole JB.   +7 more
europepmc   +2 more sources

Integrated Genome-Wide Association Studies and Selection Signature Analysis Reveal the Genetic Architecture of the Wattle Trait in Goats. [PDF]

Anim Genet
ABSTRACT Wattles are finger‐like appendages on the ventral neck of goats, serving as a distinctive morphological marker for breed identification that serves potential implications for production performance. However, their genetic basis remains incompletely characterized.
Hu S, Wei C, Feng D, Gan S.
europepmc   +2 more sources

PheWAS-ME: a web-app for interactive exploration of multimorbidity patterns in PheWAS [PDF]

Bioinformatics, 2019
Abstract Summary Electronic health records (EHRs) linked with a DNA biobank provide unprecedented opportunities for biomedical research in precision medicine. The Phenome-wide association study (PheWAS) is a widely used technique for the evaluation of relationships between genetic variants and ...
Nick Strayer, Jana K. Shirey-Rice, Yu Shyr, Joshua C. Denny, Jill M. Pulley, Yaomin Xu   +5 more
openaire   +3 more sources

Long-Term Multisystem Comorbidity Patterns in Acute Pancreatitis: Insights From Observational and Genetic Analysis. [PDF]

United European Gastroenterol J
ABSTRACT Introduction Acute pancreatitis (AP) is an inflammatory pancreatic disorder with potentially severe systemic consequences. While its immediate clinical impact is well established, the long‐term multisystem comorbidities of AP remain underexplored.
Che T, Fu T, Zhu Y, Ruan X, Sun Y, Geng J, Dan L, Wang X, Zhou C, Zou D, Arsenault BJ, Yuan S, Li X, Wang Z, Zhang X, Chen J, Zhang Y.   +16 more
europepmc   +2 more sources

ExPheWas: a browser for gene-based pheWAS associations [PDF]

, 2021
Structured Abstract Motivation The relationship between protein coding genes and phenotypes has the potential to inform on the underlying molecular function in disease etiology. We conducted a phenome-wide association study (pheWAS) of protein coding genes using a principal components analysis-based ...
Marc-André Legault, Louis-Philippe Lemieux Perreault, Marie-Pierre Dubé   +2 more
openaire   +1 more source

Landslide Susceptibility Mapping of Phewa Watershed, Kaski, Nepal

Mathematical Models in Engineering, 2023
Abstract The objective of this study was to assess the quantities of association between landslide events and causal factors in order to generate an accurate, updated landslide susceptibility map (LSM) of the Phewa watershed in Kaski, Gandaki District, Nepal.
Bimal Bahadur Kunwar, Nantakan Muensit, Kuaanan Techato, Saroj Gyawali   +3 more
openaire   +1 more source

PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational attainment

medRxiv, 2023
Mendelian Randomisation (MR) is a statistical method that estimates causal effects between risk factors and common complex diseases using genetic instruments.
L. Darrous, G. Hemani, G. Davey Smith, Z. Kutalik   +3 more
semanticscholar   +1 more source

Realising the full potential of MR-PHeWAS in cancer [PDF]

British Journal of Cancer, 2020
SummaryMR-PHeWAS is a powerful new design for discovering causal mechanisms between a disease and its many candidate risk factors in a hypothesis-free manner. This technique has great potential in the field of cancer research, provided that both powerful and principled statistical approaches are used.
openaire   +2 more sources

PLEIOTROPIC EFFECTS OF THE JAK2V617F MUTATION: A PHEWAS AND LABWAS STUDY

Journal of the American College of Cardiology
A. Teymourzadeh, K. Norland, I. Kullo
semanticscholar   +2 more sources