Results 11 to 20 of about 3,687 (173)

Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Dental caries (DC), a chronic and multifactorial disease, affects billions of people globally, posing a significant public health challenge. Despite its prevalence, the molecular mechanisms underlying DC and effective pharmacological targets remain elusive.
Bi J, Liu A, Zhang N, Chen Y, Liu C, Zhu Y, Wen H, Ma C.   +7 more
europepmc   +2 more sources

PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly. [PDF]

Curr Osteoporos Rep
Purpose of review: While GWAS has identified many loci associated with bone mineral density (BMD), translating these findings into functional insights and treatments remains challenging. Post-GWAS methods such as Transcriptome-Wide Association Study (TWAS), Phenome-Wide Association Study (PheWAS), and Mendelian Randomization (MR) provide complementary ...
Li S, Trajanoska K.
europepmc   +2 more sources

PheWAS-ME: a web-app for interactive exploration of multimorbidity patterns in PheWAS [PDF]

Bioinformatics, 2019
Abstract Summary Electronic health records (EHRs) linked with a DNA biobank provide unprecedented opportunities for biomedical research in precision medicine. The Phenome-wide association study (PheWAS) is a widely used technique for the evaluation of relationships between genetic variants and ...
Nick Strayer, Jana K. Shirey-Rice, Yu Shyr, Joshua C. Denny, Jill M. Pulley, Yaomin Xu   +5 more
openaire   +2 more sources

Identification of Alzheimer's disease subtypes and biomarkers from human multi-omics data using subspace merging algorithm. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Song Z, Huang X, Jannu AJ, Johnson TS, Zhang J, Huang K.   +5 more
europepmc   +2 more sources

Landslide Susceptibility Mapping of Phewa Watershed, Kaski, Nepal

Mathematical Models in Engineering, 2023
Abstract The objective of this study was to assess the quantities of association between landslide events and causal factors in order to generate an accurate, updated landslide susceptibility map (LSM) of the Phewa watershed in Kaski, Gandaki District, Nepal.
Bimal Bahadur Kunwar, Nantakan Muensit, Kuaanan Techato, Saroj Gyawali   +3 more
openaire   +1 more source

ExPheWas: a browser for gene-based pheWAS associations [PDF]

, 2021
Structured Abstract Motivation The relationship between protein coding genes and phenotypes has the potential to inform on the underlying molecular function in disease etiology. We conducted a phenome-wide association study (pheWAS) of protein coding genes using a principal components analysis-based ...
Marc-André Legault, Louis-Philippe Lemieux Perreault, Marie-Pierre Dubé   +2 more
openaire   +1 more source

Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The genetic and clinical factors influencing the rate of brain structure change in cognitive decline remain poorly understood. This study aimed to identify genetic variants and risk factors contributing to these changes and explore potential causal relationships.
Jin Y, Topaloudi A, Drineas P, Paschou P.   +3 more
europepmc   +2 more sources

Realising the full potential of MR-PHeWAS in cancer [PDF]

British Journal of Cancer, 2020
SummaryMR-PHeWAS is a powerful new design for discovering causal mechanisms between a disease and its many candidate risk factors in a hypothesis-free manner. This technique has great potential in the field of cancer research, provided that both powerful and principled statistical approaches are used.
openaire   +2 more sources

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts

Frontiers in Genetics, 2014
Objective: We report the first pediatric specific Phenome-Wide Association Study (PheWAS) using electronic medical records (EMRs). Given the early success of PheWAS in adult populations, we investigated the feasibility of this approach in pediatric ...
Bahram eNamjou, Bahram eNamjou, Keith eMarsolo, Keith eMarsolo, Robert eCarroll, Joshua eDenny, Marylyn D Ritchie, shefali esetia, Todd eLingren, Todd eLingren, Aleksey ePorollo, Aleksey ePorollo, Aleksey ePorollo, Beth ecobb, Cassandra ePerry, Leah Claire Kottyan, Leah Claire Kottyan, Leah Claire Kottyan, Ingrid Adele Holm, Isaac eKohane, John Barker Harley, John Barker Harley, John Barker Harley, John Barker Harley   +23 more
doaj   +1 more source

Health effects of milk consumption: phenome-wide Mendelian randomization study

BMC Medicine, 2022
Background We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population.
Shuai Yuan, Jing Sun, Ying Lu, Fengzhe Xu, Doudou Li, Fangyuan Jiang, Zhongxiao Wan, Xue Li, Li-Qiang Qin, Susanna C. Larsson   +9 more
doaj   +1 more source