Results 31 to 40 of about 6,093 (247)

Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics. [PDF]

PLoS Computational Biology, 2013
Phenome-Wide Association Studies (PheWAS) investigate whether genetic polymorphisms associated with a phenotype are also associated with other diagnoses.
Antoine Neuraz, Laurent Chouchana, Georgia Malamut, Christine Le Beller, Denis Roche, Philippe Beaune, Patrice Degoulet, Anita Burgun, Marie-Anne Loriot, Paul Avillach   +9 more
doaj   +1 more source

Scalable and Robust Regression Methods for Phenome-Wide Association Analysis on Large-Scale Biobank Data

Frontiers in Genetics, 2021
With the advances in genotyping technologies and electronic health records (EHRs), large biobanks have been great resources to identify novel genetic associations and gene-environment interactions on a genome-wide and even a phenome-wide scale.
Wenjian Bi, Wenjian Bi, Wenjian Bi, Seunggeun Lee   +3 more
doaj   +1 more source

Summary statistics from PheWAS.

, 2022
Summary statistics for logistic regression model for PheWAS where disease conditions used as outcomes, adjusted for age, age^2, sex, race and PC1-10. The effects from the rs9274619:A interacting with T2D status is documented and the disease conditions ...
Kaavya Paruchuri (13994019), Margaret Sunitha Selvaraj (13994016), Rachel Bernardo (13994025), Sara Haidermota (13994022), Stephen S. Rich (7634141), Pradeep Natarajan (819434), Gina M. Peloso (12036929)   +6 more
core   +1 more source

Genome‐wide pathogenesis interpretation using a heat diffusion‐based systems genetics method and implications for gene function annotation

Molecular Genetics & Genomic Medicine, 2020
Background Genetics is best dedicated to interpreting pathogenesis and revealing gene functions. The past decade has witnessed unprecedented progress in genetics, particularly in genome‐wide identification of disorder variants through Genome‐Wide ...
Yuan Quan, Qing‐Ye Zhang, Bo‐Min Lv, Rui‐Feng Xu, Hong‐Yu Zhang   +4 more
doaj   +1 more source

A phenome-wide association study (PheWAS) to identify the health impacts of 4-cresol sulfate in the Nagahama Study

Scientific Reports, 2023
Gut-microbiota derived metabolites are important regulators of host biology and metabolism. To understand the impacts of the microbial metabolite 4-cresol sulfate (4-CS) on four chronic diseases [type 2 diabetes mellitus, metabolic syndrome (MetS), non ...
Hui-Ting Ou, S. Kawaguchi, K. Sonomura, T. Kawaguchi, Seri Kitada, Satoshi Yoshiji, F. Brial, D. Gauguier, J. Xia, F. Matsuda   +9 more
semanticscholar   +1 more source

A Case-Crossover Phenome-wide association study (PheWAS) for understanding Post-COVID-19 diagnosis patterns

Journal of Biomedical Informatics, 2022
Graphical ...
Spencer R. Haupert, Xu Shi, Chen Chen, Lars G. Fritsche, B. Mukherjee   +4 more
semanticscholar   +2 more sources

HCLC-FC: A novel statistical method for phenome-wide association studies.

PLoS ONE, 2022
The emergence of genetic data coupled to longitudinal electronic medical records (EMRs) offers the possibility of phenome-wide association studies (PheWAS).
Xiaoyu Liang, Xuewei Cao, Qiuying Sha, Shuanglin Zhang   +3 more
doaj   +1 more source

A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study

Behavior Genetics, 2023
Genetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations are present during childhood remains unclear.
Aaron J. Gorelik, S. Paul, N. Karcher, E. Johnson, I. Nagella, L. Blaydon, Hailey Modi, I. Hansen, S. Colbert, D. Baranger, S. Norton, Isaiah Spears, B. Gordon, W. Zhang, P. Hill, T. Oltmanns, J. Bijsterbosch, A. Agrawal, A. Hatoum, R. Bogdan   +19 more
semanticscholar   +1 more source

PheWAS associations for COVID-19 susceptibility in HES data.

, 2021
PheWAS associations for COVID-19 susceptibility in HES data.
Hanan Musa (11383838), Eirini Marouli (4585735), Areti Papadopoulou (11383835), David McCoy (26701), Panos Deloukas (21564), Mathura Sivaganesan (11383841)   +5 more
core   +1 more source

A simulation study investigating power estimates in phenome-wide association studies

BMC Bioinformatics, 2018
Background Phenome-wide association studies (PheWAS) are a high-throughput approach to evaluate comprehensive associations between genetic variants and a wide range of phenotypic measures.
Anurag Verma, Yuki Bradford, Scott Dudek, Anastasia M. Lucas, Shefali S. Verma, Sarah A. Pendergrass, Marylyn D. Ritchie   +6 more
doaj   +1 more source