Results 31 to 40 of about 6,040 (161)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration [PDF]

, 2019
Background & Aims: Excess liver iron content is common and is linked to hepatic and extrahepatic disease risk. We aimed to identify genetic variants influencing liver iron content and use genetics to understand its link to other traits and diseases ...
Atabaki-Pasdar, Naeimeh, Banasik, Karina, Banerjee, Rajarshi, Baum, Patrick, Bell, Jimmy D., Beulens, Joline, Beulens, Joline, Bizzotto, Bonneford, Amelie, Brorsson, Caroline, Brunak, Soren, Caiazzo, Robert, Canouil, Mickael, de Masi, Federico, Dhennin, Veronique, Dings, Christiane, Ehrhardt, Beate, Franks, Paul W., Freijer, Jan, Froguel, Philippe, Giorgino, Toni, Graefe-Mody, Ulrike, Grempler, Rolf, Groeneveld, Lenka, Groeneveld, Lenka, Gudmundsdóttir, Valborg, Hemingway, Harry, Hennige, Anita, Hingorani, Aroon D., Jennison, Christopher, Kelly, Matt, Koopman, Anitra, Koopman, Anitra, Koopman, Anitra, Lehr, Thorsten, Lundgaard, Agnete, Mahajan, Anubha, Mari, Andrea, Neubauer, Stefan, Parisinos, Constantinos A., Patel, Riyaz S., Pattou, Francois, Pedersen, Helle, Raverdi, Violeta, Rutters, Femke, Rutters, Femke, Sackett, Peter, Scherer, Nina, Schoelsch, Corinna, Sihinecich, Iryna, Staerfeldt, Hans-Henrik, Thomas, Cecilia, Thomas, E. Louise, Thomas, Louise, Torres, Fanelly, Tura, Andrea, Verkindt, Helene, Whitcher, Brandon, Wilman, Henry R., Yaghootkar, Hanieh   +59 more
core   +7 more sources

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape [PDF]

, 2016
This is the final version of the article. Available from the publisher via the DOI in this record.Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time.
Abecasis, GR, Ahluwalia, TS, Albrecht, E, Bakker, SJL, Barlassina, C, Bartz, TM, Beilby, J, Bellis, C, Bergman, RN, Bergmann, S, Blangero, J, Blüher, M, Boehnke, M, Boerwinkle, E, Bonnycastle, LL, Boomsma, DI, Borecki, IB, Bornstein, SR, Bouchard, C, Bragg-Gresham, JL, Bruinenberg, M, Cadby, G, Campbell, H, Carola Zillikens, M, Chambers, JC, Chasman, DI, Chen, Y-DI, Chiang, CWK, Chines, PS, Chu, AY, Collins, FS, Couto Alves, A, Cucca, F, Cupples, LA, Cusi, D, D'Avila, F, de Geus, EJC, Dedoussis, G, Deloukas, P, Dimitriou, M, Döring, A, Eklund, N, Eriksson, J, Eriksson, JG, Esko, T, Farmaki, A-E, Farrall, M, Feitosa, MF, Ferreira, T, Fischer, K, Forouhi, NG, Fox, C, Frayling, T, Friedrich, N, Gansevoort, RT, Gieger, C, Gjesing, AP, Glorioso, N, Goel, A, Gorski, M, Graff, M, Grallert, H, Grarup, N, Grewal, J, Groop, LC, Gräßler, J, Hamsten, A, Hansen, T, Harder, MN, Hartman, CA, Hassinen, M, Hastie, N, Hattersley, AT, Havulinna, AS, Hayward, C, Heard-Costa, NL, Heid, IM, Heliövaara, M, Hicks, AA, Hillege, H, Hirschhorn, JN, Hofman, A, Holmen, O, Homuth, G, Hottenga, J-J, Hu, F, Hua Zhao, J, Huffman, JE, Hui, J, Hunter, DJ, Husemoen, LL, Hveem, K, Hysi, PG, Isaacs, A, Ittermann, T, Jackson, AU, Jalilzadeh, S, James, AL, Jarvelin, M-R, Jeff M, J, Jokinen, E, Jousilahti, P, Ju Sung, Y, Jula, A, Justice, AE, Jørgensen, T, Kajantie, E, Kanoni, S, Kaplan, RC, Karaleftheri, M, Keinanen-Kiukaanniemi, SM, Kinnunen, L, Knekt, PB, Koistinen, HA, Kolcic, I, Kooner, IK, Kooner, JS, Koskinen, S, Kovacs, P, Kristiansson, K, Kuh, D, Kutalik, Z, Kuusisto, J, Kyriakou, T, Kähönen, M, Laakso, M, Lahti, J, Laitinen, T, Lakka, TA, Langenberg, C, Leach, IM, Lehtimäki, T, Lewin, AM, Lichtner, P, Lindgren, CM, Lindström, J, Linneberg, A, Loos, RJF, Lorbeer, R, Lorentzon, M, Luan, J, Luben, R, Lyssenko, V, Mahajan, A, Mangino, M, Manunta, P, Marie Justesen, J, McArdle, WL, McCarthy, MI, Mcknight, B, Medina-Gomez, C, Metspalu, A, Mihailov, E, Milani, L, Mills, R, Mohlke, KL, Monda, KL, Montasser, ME, Morris, AP, Musk, AW, Mägi, R, Männistö, S, Müller, G, Müller-Nurasyid, M, Narisu, N, Njølstad, I, Nolte, IM, North, KE, O'Connell, JR, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Oostra, BA, Osmond, C, Palmer, LJ, Palotie, A, Pankow, JS, Paternoster, L, Pedersen, O, Penninx, BW, Perola, M, Peters, A, Pichler, I, Pilia, MG, Polašek, O, Pramstaller, PP, Prokopenko, I, Psaty, BM, Puolijoki, H, Pérusse, L, Qi, L, Raitakari, OT, Rankinen, T, Rao, DC, Rauramaa, R, Rayner, NW, Ribel-Madsen, R, Rice, TK, Richards, M, Ridker, PM, Ried, JS, Rivadeneira, F, Rose, LM, Rudan, I, Ryan, KA, Salomaa, V, Salvi, E, Sanna, S, Sarzynski, MA, Schlessinger, D, Scholtens, S, Schwarz, PEH, Scott, RA, Sebert, S, Shudiner, AR, Smit, JH, Smith, MT, Snieder, H, Southam, L, Sparsø, TH, Spector, TD, Stančáková, A, Stefansson, K, Steinthorsdottir, V, Stirrups, K, Stolk, RP, Strachan, DP, Strauch, K, Stringham, HM, Stumvoll, M, Swertz, MA, Swift, AJ, Sørensen, TIA, Tachmazidou, I, Tee Khaw, K, Teumer, A, Thorleifsson, G, Thorsteinsdottir, U, Tremblay, A, Tsafantakis, E, Tuomilehto, J, Tönjes, A, Uitterlinden, AG, Uusitupa, M, van der Harst, P, van der Most, PJ, van Dongen, J, van Duijn, CM, Van Vliet-Ostaptchouk, JV, Vandenput, L, Vartiainen, E, Venturini, C, Verweij, N, Viikari, JS, Vitart, V, Vohl, M-C, Vollenweider, P, Vonk, JM, Völker, U, Waeber, G, Walker, RW, Wang, SR, Wareham, NJ, Watkins, H, Widén, E, Wild, SH, Willems, SM, Willemsen, G, Wilsgaard, T, Wilson, JF, Winkler, TW, Wong, A, Wright, AF, Yerges-Armstrong, LM, Zeggini, E, Zhang, W   +275 more
core   +32 more sources

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci [PDF]

, 2016
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA.
Abbate, R, Baas, AF, Badger, SA, Bailey, MA, Betsholtz, C, Bjorkegren, JLM, Blair, R, Blankensteijn, JD, Borthwick, KM, Bottinger, EP, Bown, MJ, Bradley, DT, Bridge, K, Bumpstead, S, Carey, DJ, Carrell, DS, Clough, RE, Cockerill, G, Consortium, C, Courtois, A, Crawford, DC, Crosslin, DR, de Andrade, M, de Bakker, PIW, de Graaf, J, de Vries, J-P, Deloukas, P, Drolet, AM, Eicher, JD, Elmore, JR, Erdman, R, Eriksson, P, Ferrell, RE, Folkersen, L, Franco-Cereceda, A, Franklin, DP, Franzen, O, Futers, TS, Galora, S, Geelkerken, RH, Gerhard, GS, Giusti, B, Golledge, J, Goodall, AH, Gottesman, O, Gretarsdottir, S, Griffin, KJ, Hafez, H, Hamby, SE, Harrison, SC, Hill, AA, Hill, GB, Hughes, A, Humphries, SE, Johnson, AD, Jones, GT, Kiemeney, LA, Krysa, J, Kuivaniemi, H, Kullo, IJ, Lewis, DR, Lindholt, JS, Lipovich, L, Malinowski, J, Matthiasson, SE, McCarty, CA, Merriman, TR, Nelson, CP, Norman, PE, Oszkinis, G, Pacheco, JA, Peissig, PL, Pendergrass, S, Phillips, VL, Powell, JT, Pratesi, C, Pressure, ICB, Pulli, R, Rasmussen-Torvik, LJ, Ritchie, MD, Roake, J, Romaine, SPR, Ruusalepp, A, Ryer, EJ, Sakalihasan, N, Samani, NJ, Saracini, C, Saratzis, A, Sayers, RD, Schadt, EE, Scott, DJA, Smelser, DT, Smith, A, Stefansson, K, Stirrups, K, Strauss, E, Teijink, JAW, Thompson, JR, Thompson, MM, Thomson, IA, Thorleifsson, G, Thorsteinsdottir, U, Tromp, G, van Bockxmeer, FM, van Rij, AM, van Sambeek, MR, van Sterkenburg, SM, van't Hof, FNG, Vasudevan, TM, Verhoeven, EL, Verissimo, AR, Verma, A, Verma, SS, Webb, TR, Wei, W, Wijmenga, C, Williams, MJA, Zeebregts, CJ, Zy, ZY   +118 more
core   +11 more sources

An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

Genome Medicine, 2018
Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear.
Junfei Zhao, Feixiong Cheng, Peilin Jia, Nancy Cox, Joshua C. Denny, Zhongming Zhao   +5 more
doaj   +1 more source

Psychiatric genetics and the structure of psychopathology [PDF]

, 2018
For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to define categorical syndromes based on clusters of symptoms and signs, and, to some extent ...
Andreassen, Ole A., Edenberg, Howard J., Faraone, Stephen V., Glatt, Stephen J., Kendler, Kenneth S., Smoller, Jordan W.   +5 more
core   +1 more source

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.

PLoS Genetics, 2022
The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data.
Anurag Verma, Noah L Tsao, Lauren O Thomann, Yuk-Lam Ho, Sudha K Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C Crawford, Jimmy T Efird, Jennifer E Huffman, Adriana Hung, Kerry L Ivey, Michael G Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D Ritchie, VA Million Veteran Program COVID-19 Science Initiative, Kyong-Mi Chang, Kelly Cho, Juan P Casas, Philip S Tsao, J Michael Gaziano, Christopher O'Donnell, Scott M Damrauer, Katherine P Liao   +36 more
doaj   +1 more source

Increased risk of multisystem comorbidities and disease trajectories following hyperthyroidism: evidence from the 0.5 million UK Biobank population

Endocrine Connections
Methods: After a 1:4 propensity score matching, a total of 5,832 hyperthyroidism patients and 22,579 controls from the UK Biobank were included in this study.
Qiuyuan Chen, Doudou Chen, Xinpan Wang, Yunhao Zheng, Longyao Zhang, Zaiming Li, Xiaoyu Wu, Qin Chen, Ruyang Zhang, Feng Chen, Tao Yang, Xuqin Zheng, Yongyue Wei   +12 more
doaj   +1 more source

EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children [PDF]

, 2013
Common variations at the loci harboring the fat mass and obesity gene (FTO), MC4R, and TMEM18 are consistently reported as being associated with obesity and body mass index (BMI) especially in adult population.
Cobb, Beth, Crimmins, Nancy A., Harley, John B., Holm, Ingrid A., Keddache, Mehdi, Kennebeck, Stephanie, Kohane, Isaac S., Li, Rongling, Lingren, Todd, Marsolo, Keith, Martin, Lisa, Namjou, Bahram, Perry, Cassandra, Solti, Imre, Wagner, Michael   +14 more
core   +1 more source

Flipping the odds of drug development success through human genomics [PDF]

, 2017
Drug development depends on accurately identifying molecular targets that both play a causal role in a disease and are amenable to pharmacological action by small molecule drugs or bio-therapeutics, such as monoclonal antibodies.
Casas, JP, Chopade, S, Denaxas, S, Finan, C, Gaulton, A, Hemingway, H, Hingorani, A, Kruger, F, Kuan, V, MacAllister, R, Overington, J, Prieto, D, Sofat, R   +12 more
core   +1 more source

Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study.

PLoS Genetics, 2014
We performed a Phenome-wide association study (PheWAS) utilizing diverse genotypic and phenotypic data existing across multiple populations in the National Health and Nutrition Examination Surveys (NHANES), conducted by the Centers for Disease Control ...
Molly A Hall, Anurag Verma, Kristin D Brown-Gentry, Robert Goodloe, Jonathan Boston, Sarah Wilson, Bob McClellan, Cara Sutcliffe, Holly H Dilks, Nila B Gillani, Hailing Jin, Ping Mayo, Melissa Allen, Nathalie Schnetz-Boutaud, Dana C Crawford, Marylyn D Ritchie, Sarah A Pendergrass   +16 more
doaj   +1 more source