Results 81 to 90 of about 3,687 (173)

Degradation Dynamics and Conservation Imperatives of Phewa Wetland, Nepal

The Himalayan Geographers
Phewa Wetland, a vital ecological area within Nepal’s Phewa Lacustrine Plain, is experiencing rapid degradation due to escalating natural and anthropogenic pressures. This study employs a mixed-method approach combining field observation, GIS-based spatial analysis, and secondary data review to assess the wetland’s ecological status, sedimentation ...
Ramjee Prasad Pokharel, Daya Sagar Subedi   +1 more
openaire   +1 more source

Role of Vegetation for the Protection of Phewa Watershed, Kaski, Nepal [PDF]

Environment and Ecology Research, 2022
Bimal Bahadur Kunwar, Basanta Raj Adhikari, Nantakan Muensit, Kuaanan Techato, Saroj Gyawali   +4 more
openaire   +1 more source

Precision Target Discovery for Migraine: An Integrated GWAS-eQTL-PheWAS Pipeline

Molecules
Migraine is a complex neurological disorder that severely compromises quality of life. Current therapies remain inadequate, creating an urgent need for precision medicine approaches. To bridge this gap, we integrated genome-wide association studies (GWASs) and multi-tissue expression quantitative trait loci (eQTL) data.
Xianting Liu, Qingming Liu, Haoning Zhu, Xiao Zhou, Xinyao Li, Ming Hu, Fu Peng, Jianguang Ji, Shu Yang   +8 more
openaire   +2 more sources

Multiancestry transferability of a polygenic risk score for diverticulitis

BMJ Open Gastroenterology
Objective Polygenic risk scores (PRS) for diverticular disease must be evaluated in diverse cohorts. We sought to explore shared genetic predisposition across the phenome and to assess risk stratification in individuals genetically similar to European ...
Richard Peek, Eric R Gamazon, Jamie Robinson, Jonathan D Mosley, Thomas E Ueland, Christopher Neylan, John P Shelley, Lillias Maguire, Alexander T Hawkins   +8 more
doaj   +1 more source

Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study

Frontiers in Pharmacology
BackgroundThe relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.MethodsA two-sample
Yilong Lin, Yilong Lin, Yue Zhang, Songsong Wang, Lin Cao, Ruidan Zhao, Xilai Ma, Qiaolu Yang, Liyi Zhang, Qingmo Yang, Qingmo Yang   +10 more
doaj   +1 more source

Phenotypic findings associated with variation in elastin

HGG Advances
Summary: Variation in the elastin gene (ELN) may contribute to connective tissue disease beyond the known disease associations of supravalvar aortic stenosis and cutis laxa.
Anne Justice, Melissa A. Kelly, Gary Bellus, Joshua D. Green, Raza Zaidi, Taylor Kerrins, Navya Josyula, Teresa R. Luperchio, Beth A. Kozel, Marc S. Williams   +9 more
doaj   +1 more source

Identifying the high-risk slope locations in Phewa Lake Catchment

OODBODHAN
Landslides in Phewa Lake Catchment, triggered by slope failure, poses risks to life, infrastructure, and degradation of soil quality while contributing to shrinkage of Phewa Lake. This study identifies potentially unstable slope within the catchment using landslide susceptibility mapping and then assesses slope stability of a selected unstable slope. A
Suyogya Pun, Abhay Kumar Mandal, Samrat Poudel   +2 more
openaire   +1 more source

Phenome‐wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers

Cancer Medicine
Background Ovarian cancer (OC) is commonly diagnosed among older women who have comorbidities. This hypothesis‐free phenome‐wide association study (PheWAS) aimed to identify comorbidities associated with OC, as well as traits that share a genetic ...
Anwar Mulugeta, Amanda L. Lumsden, Iqbal Madakkatel, David Stacey, S. Hong Lee, Johanna Mäenpää, Martin K. Oehler, Elina Hyppönen   +7 more
doaj   +1 more source

Novel insights into the pleiotropic health effects of growth differentiation factor 11 gained from genome-wide association studies in population biobanks

BMC Genomics
Background Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β (TGF-β) superfamily that has gained considerable attention over the last decade for its observed ability to reverse age-related deterioration of multiple ...
Jessica Strosahl, Kaixiong Ye, Robert Pazdro   +2 more
doaj   +1 more source

Cross-ancestry genome-wide association studies of liver function biomarkers uncover pleiotropic variants, systemic disease links and therapeutic targets

Genome Medicine
Background Liver function-related quantitative biomarkers (LFQBs) are essential for assessing hepatic health, yet prior genome-wide association studies (GWAS) have largely studied them in isolation. We conducted cross-ancestry GWAS meta-analyses on seven
Wentao Yao, Jingyi Fan, Jing Lu, Haiyan Guo, Chengxiao Yu, Xuehui Wang, Yun Wang, Yu Zhang, Qingning Duan, Lihua Cheng, Chen Zhou, Zhaohui Wang, Juncheng Dai, Hongxia Ma, Qun Zhang, Ci Song, Hongbing Shen   +16 more
doaj   +1 more source