Results 101 to 110 of about 6,310 (247)

Genetic evidence supports a cortical neuroprotective role of GLP‐1 receptor activation in Alzheimer's disease: A drug‐target Mendelian randomization study

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Whether glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) activation lowers Alzheimer's disease (AD) risk via peripheral metabolic improvement or direct neuroprotection remains unclear. METHODS Using blood and brain‐cortex cis‐acting expression quantitative trait loci (cis‐eQTLs) for GLP‐1R as instruments, we performed cis ...
Li Jiang   +17 more
wiley   +1 more source

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

open access: yesTranslational Psychiatry, 2023
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders.
Sandra Sanchez-Roige   +26 more
doaj   +1 more source

Cohort-specific "B1_ALL" PRS PheWAS Results for AFR Ancestry, Unadjusted for BMI.

open access: yes, 2023
Cohort-specific "B1_ALL" PRS PheWAS Results for AFR Ancestry, Unadjusted for BMI.
Ritoban Kundu (10937289)   +8 more
core   +1 more source

Genome‐Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID‐19

open access: yesInfluenza and Other Respiratory Viruses, Volume 20, Issue 10, October 2026.
ABSTRACT Background Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although previous studies have explored genetic susceptibility to influenza infection, the genetic basis of influenza hospitalization and its relationship with respiratory diseases like COVID‐19 remain poorly understood ...
Xiao Xue   +4 more
wiley   +1 more source

Cohort-specific "B1_ALL" PRS PheWAS Results for EAS Ancestry, Adjusted for BMI.

open access: yes, 2023
Cohort-specific "B1_ALL" PRS PheWAS Results for EAS Ancestry, Adjusted for BMI.
Ritoban Kundu (10937289)   +8 more
core   +1 more source

A Genome‐Wide Meta‐Analysis of Functional Dyspepsia in 1,168,899 Individuals Implicates Immune Pathways in Disease Susceptibility

open access: yesNeurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
Our findings indicate that genetic variants in immune‐related genes (HLA‐DQB1 and DHX36) may influence functional dyspepsia risk by modulating gastrointestinal inflammatory responses, reinforcing the role of an immune‐mediated component in disease susceptibility and nominating these genes for further mechanistic investigation.
Cristian Díaz‐Muñoz   +19 more
wiley   +1 more source

Pharmacogenomics in the Age of GWAS, Omics Atlases, and PheWAS

open access: yes, 2018
The search for causative pharmacogenomic loci is being transformed by integrative omics pipelines, but their outputs have only begun being applied to test design. We assess the direction of the field in light of Biobanks/PheWAS, omics atlases, and AI. We first assess the potential of recent epigenome and spatial genome concepts, datasets, and methods ...
Allyn-Feuer, Ari   +2 more
openaire   +2 more sources

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort

open access: yesPLOS ONE, 2018
Abstract In this study, we perform a full genome-wide association study (GWAS) to identify statistically significantly associated single nucleotide polymorphisms (SNPs) with three red blood cell (RBC) components and follow it with two independent PheWASs to examine associations between phenotypic data (case-control ...
Robert W. Read   +7 more
openaire   +5 more sources

ghxdghxd/PheWAS-across-Chinese-pregnant-women-from-ulcWGS: v1.0.1

open access: yes
<p>The raw code for "Phenome-wide association study in a Chinese population of 25,639 pregnant women Reveals loci associated with Maternal Comorbidities and Child Health"</p> <p>Phenome-wide association studies (PheWAS) have ...
JT Guo
core   +1 more source

PheWAS analysis for rs1047626 (Gene Atlas, last accessed 16/05/2022).

open access: yes, 2023
PheWAS analysis for rs1047626 (Gene Atlas, last accessed 16/05/2022).
Ana Roca-Umbert (17041620)   +11 more
core   +1 more source

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