Designing New Natural‐Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research [PDF]
Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.We report the role of the fatty acyl chains in biological activities of phosphatidic acids (PA). Several PA probes having two different fatty acyl chains were synthesized through a multi‐steps synthesis and bearing various fluorophores or photo‐cross‐linkers (PCL).
Antoine Schlichter +29 more
wiley +3 more sources
Putting the pH into phosphatidic acid signaling [PDF]
BMC Biology, 2011 Abstract: The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA.
Shin, John J, Loewen, Christopher J
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Mass Spectrometry Reviews, EarlyView., 2023 Abstract Analysis of triacylglycerol (TG) and phospholipid sn‐positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods.
Mikael Fabritius, Baoru Yang
wiley +1 more source
Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]
, 2016 Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan +5 more
core +2 more sources
Spontaneous Curvature of Phosphatidic Acid and Lysophosphatidic Acid [PDF]
Biochemistry, 2005 The formation of phosphatidic acid (PA) from lysophosphatidic acid (LPA), diacylglycerol, or phosphatidylcholine plays a key role in the regulation of intracellular membrane fission events, but the underlying molecular mechanism has not been resolved.
Kooijman, E.E. +6 more
openaire +5 more sources
Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis [PDF]
, 2015 This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/
Edwardson, J Michael +4 more
core +2 more sources
Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms [PDF]
, 2013 Peer reviewedPublisher ...
Dennis, Rowena J +5 more
core +2 more sources
Comparative lipid profiling dataset of the inflammation-induced optic nerve regeneration. [PDF]
, 2019 In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RGCs die after acute injury and in progressive degenerative diseases such as glaucoma; this can lead to permanent vision loss and, eventually, blindness ...
Bhattacharya, Sanjoy K +5 more
core +1 more source
Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications [PDF]
, 2019 Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes ...
Alza, Natalia Paola +4 more
core +1 more source
Regulation of mTOR by Phosphatidic Acid? [PDF]
Cancer Research, 2007 Abstract Interest in the regulation of the mammalian target of rapamycin (mTOR) has increased substantially in recent years largely because of an apparent link between mTOR and survival signals in human cancer cells. Much has been learned about the regulation of mTOR in response to survival signals generated by phosphatidylinositol 3 ...
openaire +3 more sources