PHOSPHATIDIC ACID SYNTHESIS IN YEAST [PDF]
Biochemical Journal, 1965 1. The presence of palmitoyl-CoA-l-glycerol 1-phosphate palmitoyltransferase (EC2.3.1.15) has been demonstrated in a particulate fraction of baker's yeast. 2. The enzyme has been characterized, and its activity studied as a function of pH and concentration of substrates. 3. Inhibition by thiol poisons and protection by acyl-CoA have been used to obtain
F. Lynen, N. J. Kuhn
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The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation. [PDF]
PLoS ONE, 2014 PDZGEF is a guanine nucleotide exchange factor for the small G protein Rap. It was recently found that PDZGEF contributes to establishment of intestinal epithelial polarity downstream of the kinase Lkb1.
Sarah V Consonni +3 more
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Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds
Journal of Cell Biology, 2020 Tei et al. developed optogenetic phospholipase D enzymes for precisely generating the pleiotropic lipid second-messenger phosphatidic acid on specific organelle membranes and applied these tools to elucidate that a PM pool of phosphatidic acid can ...
Reika Tei, Jeremy M. Baskin
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Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
, 2009 The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria +2 more
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Recent advances in expanding the coverage of the lipidome [PDF]
, 2017 The lipidome comprises a large array of molecules with diverse physicochemical properties. Lipids are structural components of cells, act as a source of energy, and function as signaling mediators.
Kamphorst, Jurre J., Tumanov, Sergey
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Spontaneous Curvature of Phosphatidic Acid and Lysophosphatidic Acid [PDF]
Biochemistry, 2005 The formation of phosphatidic acid (PA) from lysophosphatidic acid (LPA), diacylglycerol, or phosphatidylcholine plays a key role in the regulation of intracellular membrane fission events, but the underlying molecular mechanism has not been resolved.
Kooijman, E.E. +6 more
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RASSF4: Regulator of plasma membrane PI(4,5)P2. [PDF]
, 2017 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/
Balla +12 more
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Phosphatidic acid modulation of Kv channel voltage sensor function
eLife, 2014 Membrane phospholipids can function as potent regulators of ion channel function. This study uncovers and investigates the effect of phosphatidic acid on Kv channel gating.
Richard K Hite +2 more
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Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]
, 2008 Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ahn +43 more
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Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]
, 2016 Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan +5 more
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