Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis [PDF]
, 2015 This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/
Edwardson, J Michael +4 more
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Effect of oral administration of soy-derived phosphatidic acid on concentrations of phosphatidic acid and lyso-phosphatidic acid molecular species in human plasma [PDF]
Journal of the International Society of Sports Nutrition, 2013 Background The glycerophospholipid Phosphatidic acid (PA) has been identified as a potential nutritional treatment for gastrointestinal disorders. Dietary food sources rich in PA include cabbage and radish leaves as well as Mallotus japonicas, a Japanese edible herb historically used for the treatment of stomach ulcers.
Ryan P. Lowery +5 more
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Regulation of mTOR by Phosphatidic Acid? [PDF]
Cancer Research, 2007 Abstract Interest in the regulation of the mammalian target of rapamycin (mTOR) has increased substantially in recent years largely because of an apparent link between mTOR and survival signals in human cancer cells. Much has been learned about the regulation of mTOR in response to survival signals generated by phosphatidylinositol 3 ...
openaire +3 more sources
The role of phosphatidic acid in astrocyte intracellular signalling [PDF]
, 1990 1. Astrocyte-enriched cultures prepared from the neonatal rat cerebral cortex were used to assess the effects of putative mitogens on astroglial proliferation.
Jakobson, Katherine
core +1 more source
An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles
BMC Cell Biology, 2008 Background Insulin stimulates glucose uptake by adipocytes through increasing translocation of the glucose transporter GLUT4 from an intracellular compartment to the plasma membrane.
Welsh Gavin I +5 more
doaj +1 more source
Frontiers in Plant Science, 2022 Pollen germination and subsequent pollen tube elongation are essential for successful land plant reproduction. These processes are achieved through well-documented activation of membrane trafficking and cell metabolism. Despite this, our knowledge of the
Natalia Serrano +4 more
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Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes [PDF]
, 2015 The composition of the mitochondrial membrane is important for its architecture and proper function. Mitochondria depend on a tightly regulated supply of phospholipid via intra-mitochondrial synthesis and by direct import from the endoplasmic reticulum ...
Abid Ali, F +9 more
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Comparative lipid profiling dataset of the inflammation-induced optic nerve regeneration. [PDF]
, 2019 In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RGCs die after acute injury and in progressive degenerative diseases such as glaucoma; this can lead to permanent vision loss and, eventually, blindness ...
Bhattacharya, Sanjoy K +5 more
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Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis [PDF]
, 2014 Mechanistic target of rapamycin (mTOR) controls global translation of mRNA into protein by phosphorylating p70 S6 kinase (S6K) and eIF4E-binding protein-1. Akt and Rheb, a GTP-binding protein, regulate mTOR protein kinase activity. Molting in crustaceans
Abuhagr, Ali M. +3 more
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Plant Physiology, 2018 DGAT1 and DGK2/3/5 modulate the conversion of DAG to TAG and PA, respectively, and determine cold stress tolerance in Arabidopsis. Plants accumulate the lipids phosphatidic acid (PA), diacylglycerol (DAG), and triacylglycerol (TAG) during cold stress ...
Wei-Juan Tan +7 more
semanticscholar +1 more source