Results 101 to 110 of about 17,374 (201)

Targeting NME3 to Restore Mitochondrial Fission‐Fusion Balance Defines a Novel Disease‐Modifying Strategy for Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
NME3 deficiency disrupts mitochondrial fission‐fusion balance, causing neuronal damage via ROS. Pharmacological Drp1 inhibition (Mdivi‐1) or substantia nigra‐specific NME3 overexpression restores mitochondrial equilibrium, prevents dopaminergic neuron loss, and alleviates motor deficits in PD models.
Chen Qiao, Xiang‐Qi Hu, Shen‐Han Xu, Meng‐Fan Yao, Jun‐Peng Liu, Lei Cao   +5 more
wiley   +1 more source

Genetic Basis of Cuticular Hydrocarbon Variation in the Desert Ant Cataglyphis niger

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Cuticular hydrocarbons (CHCs) are a ubiquitous component of ant cuticles that are used for a wide range of chemical signaling functions, especially recognition. Here we tested for a genetic basis of CHC variation in the desert ant Cataglyphis niger. We applied a genomic mapping approach to discover associations between CHCs and 20 quantitative trait ...
Shani Inbar, Besan Saied, Pnina Cohen, Zeev Frenkel, Yoann Pellen, Abraham B. Korol, Eyal Privman   +6 more
wiley   +1 more source

Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis

Glia, Volume 74, Issue 3, March 2026.
Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Amelia Trimarco, Matteo Audano, Rosa La Marca, Marta Pellegatta, Paolo Canevazzi, Mariaconcetta Cariello, Marta Falco, Silvia Pedretti, Gabriele Imperato, Alessandro Cestaro, Paola Podini, Giorgia Dina, Angelo Quattrini, Luca Massimino, Donatella Caruso, Nico Mitro, Carla Taveggia   +16 more
wiley   +1 more source

Synthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate.

Org Biomol Chem, 2022
Andringa RLH, Jonker M, Minnaard AJ.
europepmc   +1 more source

Longitudinal clinical and preclinical studies identify hetrombopag as a potent chelator for systemic iron overload

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Iron overload (IO) is a pathological condition characterized by excessive iron accumulation, leading to systemic functional impairment. It frequently occurs in patients with congenital or acquired anemia, such as aplastic anemia, who require long‐term transfusions.
Yufei Zhao, Lingxiao Xing, Baohang Zhang, Wenrui Yang, Xiangrong Hu, Xu Liu, Xiawan Yang, Weiru Liang, Yimeng Shi, Jing Hu, Xiaoxia Li, Rui Kang, Guangxin Peng, Yuan Li, Xiao Hu, Youzhen Xiong, Liping Jing, Weiping Yuan, Sidan Li, Fengkui Zhang, Xin Zhao   +20 more
wiley   +1 more source

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, Volume 3, Issue 1, March 2026.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Regulation of phosphatidic acid phosphatase

The FASEB Journal, 2010
Phosphatidic acid phosphatase (PAP) catalyzes the dephosphorylation of phosphatidic acid (PA) to yield diacylglycerol (DAG) and P i . The DAG generated in the reaction is used for the synthesis of triacylglycerol (TAG), and for the synthesis of ...
openaire   +1 more source

Flow Cytometry Role in Unlocking New Frontiers for Nanomedicine Applications of Plant‐Derived Vesicles

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound vesicles released by any cell type under both physiological and pathological conditions. They carry a wide array of bioactive molecules, including microRNAs (miRNAs), lipids, proteins and other small biomolecules, and therefore play a key role in intercellular communication by ...
Tamer Esmail, Sabino Porro, Francesca D'Ascanio, Domenico De Bellis, Arianna Aquilini‐Mummolo, Giulia Colasante, Pasquale Simeone, Ayesha Younas, Marwa Balaha, Mariagiulia Filoso, Luana D'Onofrio, Melania Dovizio, Eleonora Aruffo, Piero Di Carlo, Lorenzo Secondi, Federica Flamminii, Tiziana Pietrangelo, Chiara Porro, Patrizia Ballerini, Angelo Cichelli, Paola Lanuti   +20 more
wiley   +1 more source

Phosphatidic Acid [PDF]

, 2020
openaire   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source