Results 111 to 120 of about 17,374 (201)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Trends in Dietary Exosome‐Like Nanoparticles: Preparation, Nutritional Functions, Bioactive Delivery Efficacy, Human Health Effects, and Future Product Development

Small Structures, Volume 7, Issue 3, March 2026.
This graphical abstract summarizes the current advances in dietary exosome‐like nanoparticles (ELNs), highlighting their biogenesis pathways (MVB‐dependent, vacuole‐mediated, and EXPO routes), molecular composition (nucleic acids, lipids, proteins, and bioactive compounds), and major preparation strategies including differential ultracentrifugation ...
Nidesha Randeni, Jinhai Luo, Min‐Hsiung Pan, Baojun Xu   +3 more
wiley   +1 more source

Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. [PDF]

J Clin Invest, 2015
Masuda M, Miyazaki-Anzai S, Keenan AL, Okamura K, Kendrick J, Chonchol M, Offermanns S, Ntambi JM, Kuro-O M, Miyazaki M.   +9 more
europepmc   +1 more source

Genome‐wide association study identifies consistent genomic loci for yield and nutritional quality in Ethiopian sorghum landraces

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Identifying genomic regions linked to yield and quality is crucial for sorghum (Sorghum bicolor L.) improvement, but limited studies on its genome and diversity hinder breeding efforts. This study aimed to identify phenotypic variance and common quantitative trait nucleotides (QTNs) associated with genomic regions linked with grain yield and ...
Chalachew Endalamaw, Temesgen M. Menamo, Firezer G. Kebede, Zeleke Wondimu, Hailekiros Tadesse Tekle, Kwame Shamuyarira, Angeline Jacoby, Maryke Tine Labuschagne   +7 more
wiley   +1 more source

Phosphatidylinositol transfer protein α binds microcolins in its open conformation

Acta Crystallographica Section D, Volume 82, Issue 3, Page 246-252, March 2026.
We report the crystal structure of human PITPα in complex with microcolin H at 2.0 Å resolution, revealing that microcolins bind covalently within the lipid‐binding cavity and stabilize PITPα in an open conformation with a markedly enlarged cavity relative to the lipid‐bound state.
Andrea Eisenreichova, Martin Klima, Tamas Balla, Evzen Boura   +3 more
wiley   +1 more source

Lactose‐Derived Carbohydrates Induce Sexually Dimorphic Nutritional Programming Effects on Lifespan in Drosophila melanogaster

Aging Cell, Volume 25, Issue 3, March 2026.
Early‐life co‐consumption of galactose and glucose (hydrolyzed lactose) programs Drosophila melanogaster lifespan in a sex‐specific manner. Particularly, the co‐consumption of galactose and glucose programs extended lifespan when female flies were challenged by obesogenic diets later in life, and this is concomitant with remodeling of lipid metabolism,
Peixin Sun, Shiying Shao, Robin W. Creemers, Anna F. Bekebrede, Jing Tang, Steven Driever, Jaap Keijer, Evert M. van Schothorst   +7 more
wiley   +1 more source

Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control

Molecular Ecology, Volume 35, Issue 5, March 2026.
ABSTRACT Malaria, a febrile disease caused by the Plasmodium parasites and transmitted by mosquitoes, is a leading cause of mortality in children under 5 in endemic countries. The widespread deployment of insecticide‐treated bed nets (ITNs) has significantly reduced malaria transmission, but rising levels of insecticide resistance threaten to halt the ...
Harun N. Njoroge, Lilian Namuli, Sanjay C. Nagi, Anastasia Hernandez‐Koutoucheva, Daniel P. McDermott, Erin Knight, Samuel Gonahasa, Amy Lynd, Ambrose Oruni, Catherine Maiteki‐Sebuguzi, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Moses R. Kamya, Grant Dorsey, Janet Hemingway, Sarah G. Staedke, Chris Clarkson, Alistair Miles, Eric R. Lucas, Martin J. Donnelly   +21 more
wiley   +1 more source

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering

New Phytologist, Volume 249, Issue 5, Page 2196-2214, March 2026.
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Prasad Parchuri, Sean T. McGuire, Matthew G. Garneau, Niña Alyssa M. Barroga, Philip D. Bates   +4 more
wiley   +1 more source

Natural Variation in TaFAD8‐D Promoter Enhances Thermotolerance in Wheat Through Fatty Acid and Lipid Remodelling

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1251-1268, March 2026.
ABSTRACT Heat stress (HS) has become an increasing threat to wheat productivity under global warming. However, the genetic loci for thermotolerance and the underlying molecular mechanisms remain largely unknown. In this study, genetic mapping identified a thermotolerance locus, QMpe.cau‐2D, encoding fatty acid desaturase 8 (FAD8), with the transposable
Hongjian Yu, Tianyu Lan, Weiwei Mao, Yongfa Wang, Xiaoyu Zhang, Mengsi Ma, Shuo Chen, Guang Chen, Qiang Li, Zhaorong Hu, Mingming Xin, Yingyin Yao, Weilong Guo, Zhongfu Ni, Qixin Sun, Huiru Peng   +15 more
wiley   +1 more source

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, Volume 49, Issue 3, Page 1598-1616, March 2026.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source