Protein Kinase C Regulates Meiosis in Mammalian Oocytes
BioEssays, Volume 48, Issue 1, January 2026.Protein kinase C (PKC) participates in the regulation of mammalian oocyte meiosis. PKC is involved in meiosis resumption in prophase I and in the stabilization of meiosis I and meiosis II spindles. PKC stimulates the maturation‐promoting factor during fertilization and stabilizes the mitotic spindle during early embryo development. ABSTRACT The protein
Jaroslav Kalous +2 more
wiley +1 more source
Engineering Liposomes for Neurodegenerative Diseases: Targeted Delivery and Regenerative Potential
ChemNanoMat, Volume 12, Issue 1, January 2026.Liposomal nanocarriers offer therapeutic promise for neurodegenerative diseases by encapsulating diverse agents such as neurotrophic factors and mRNA while targeting the blood‐brain barrier. Designed to stimulate neuronal repair and restore function, these lipid vesicles advance strategies for optimized design and central nervous system delivery ...
Oybek Ashirov +3 more
wiley +1 more source
Resynthesis of phosphatidylinositol in permeabilized neutrophils following phospholipase Cβ activation: transport of the intermediate, phosphatidic acid, from the plasma membrane to the endoplasmic reticulum for phosphatidylinositol resynthesis is not dependent on soluble lipid carriers or vesicular transport [PDF]
, 1999 Jacqueline L. Whatmore +4 more
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Clinical &Translational Immunology, Volume 15, Issue 1, 2026.Extracellular vesicles carry proteins, lipids and metabolites, reflecting cellular health and disease. This review examines how mass spectrometry‐based multi‐omics—proteomics, lipidomics and metabolomics is transforming EV characterisation. We address integration strategies, standardisation challenges and emerging technologies, bridging multi‐omics ...
Akila Wijerathna‐Yapa +2 more
wiley +1 more source
HEPES in Cell Culture Alters the Multi‐Omics Profile Exhibited by Gaucher Disease Fibroblasts
Journal of Cellular Biochemistry, Volume 127, Issue 1, January 2026.ABSTRACT Lysosomal function can be affected by components in cell culture. This in turn may influence cellular metabolism and, consequently, research and diagnostics outcomes. One such component is the commonly used pH buffer 4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic acid (HEPES).
Eleonore M. Corazolla +14 more
wiley +1 more source
Mass Spectrometry Reviews, Volume 45, Issue 1, Page 4-36, January/February 2026.Abstract Analysis of triacylglycerol (TG) and phospholipid sn‐positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods.
Mikael Fabritius, Baoru Yang
wiley +1 more source
Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. [PDF]
J Clin Invest, 2015 Masuda M +9 more
europepmc +1 more source
Fine-tuning phosphatidic acid production for optimal plant stress responses [PDF]
Qiuwen Gong +3 more
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Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges
Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca +2 more
wiley +1 more source