Results 81 to 90 of about 114,039 (255)

Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes

Journal of Lipid Research, 2013
ABCB4 is necessary for the secretion of phospholipids from hepatocytes into bile and for the protection of cell membranes against bile salts. Lipid rafts are plasma membrane microdomains containing high contents of cholesterol and sphingolipids, which ...
Shin-ya Morita, Tadanori Tsuda, Manami Horikami, Reiko Teraoka, Shuji Kitagawa, Tomohiro Terada   +5 more
doaj   +1 more source

Interaction of curcumin with phosphatidylcholine: A spectrofluorometric study.

, 1999
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione], the main constituent of the rhizomes of the plant Curcume longa L. (turmeric), is a powerful antioxidant in both enzymatic and nonenzymatic systems.
Sudharshan, E, Udaya Sankar, K., Appu Rao, A. G., Began, G.   +3 more
core  

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

New hypothesis: a gut-lipid-kidney axis in constipated CKD patients—insights from multi-omics triangulation

mSphere
Patients with chronic kidney disease (CKD) frequently experience constipation, often linked to gut microbiota disruptions. We hypothesized that constipation is not merely a comorbidity but a driver of adverse outcomes through a specific host-microbial ...
Yichen Liu, Jin Zhao, Jinguo Yuan, Zixian Yu, Jie Liu, Xiaoxuan Ning, Shiren Sun   +6 more
doaj   +1 more source

Transbilayer distribution and mobility of phosphatidylcholine in intact erythrocyte membranes. A study with phosphatidylcholine exchange protein

, 1980
The exchange of phosphatidylcholine between intact human or rat erythrocytes and rat liver microsomes was greatly stimulated by phosphatidylcholine-specific exchange proteins from rat liver and beef liver.
op den Kamp, J.A.F., Wirtz, K.W.A., van Deenen, L.L.M., Universiteit Utrecht, Poorthuis, B.J.H.M., Sub Membrane Enzymology begr. 01-06-12, van Meer, G., Dep Scheikunde, Membrane Enzymology   +8 more
core  

Phosphatidylcholine-dependent phospholipase C in rat liver chromatin

, 1999
Phosphatidylcholine-dependent phospholipase C is an enzyme which hydrolyses phosphatidylcholine giving origin to diacylglicerol and phosphorylcholine. Diacylglicerol has many effect and activates also protein kinase C.
ALBI, Elisabetta, Viola Magni, Mariapia
core   +1 more source

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Human cytomegalovirus promotes de novo PC synthesis during early virus replication

Journal of Virology
Human cytomegalovirus (HCMV) infection reprograms metabolism, including lipid synthesis. While several metabolite-related pathways exhibit altered activity in infected cells, the alteration of lipid-related pathways by HCMV has not been examined beyond ...
Ian Kline, Rebekah L. Mokry, Yuecheng Xi, Magí Passols Manzano, Sidnie Layesa, Nowroz Sohrab Ali, Melissa A. Moy, Felicia D. Goodrum, John G. Purdy   +8 more
doaj   +1 more source

Ca2+-induced isotropic motion and phosphatidylcholine flip-flop in phosphatidylcholine-cardiolipin bilayers

, 1980
Ca2+ induces a structural change in phosphatidylcholine-cardiolipin bilayers, which is visualised by freeze-fracturing as lipidic particles associated with the bilayer and is detected by 31P-NMR as isotropic motion of the phospholipids. In this structure
Verkleij, A.J., Gier, J. de, Gerritsen, W.J., Kruijff, B. de, Deenen, L.L.M. van   +4 more
core