Results 91 to 100 of about 114,039 (255)

Lipid remodeling and ferroptosis in phosphatidylcholine-mediated tumor–stroma crosstalk [PDF]

Tumor progression and therapy resistance are formed not only by cancer cell intrinsic mechanisms but also by dynamic interactions with the surrounding tumor stroma.
Ion Dan Mironescu, Chella Perumal Palanisamy, Monica Mironescu, Gopalakrishnan Velliyur Kanniappan, Lavanya Loganathan, Meenakshi Kaniyur Chandrasekaran, Rathi Muthaiyan Ahalliya, Manikandan Vani Raju, Palanisamy, Chella Perumal, Loganathan, Lavanya, Kaniyur Chandrasekaran, Meenakshi, Mironescu, Monica, Muthaiyan Ahalliya, Rathi, Vani Raju, Manikandan, Mironescu, Ion Dan, Velliyur Kanniappan, Gopalakrishnan   +15 more
core   +1 more source

Phosphatidylcholine-pyridine complex [PDF]

, 1998
Методом спектроскопии ЯМР на ядрах ¹³С обнаружено взаимодействие в D₂O пиридина с фосфатидилхолином – фосфолипидом клеточных мембран. Структура комплекса, установлена полуэмпирическим квантово-химическим методом MNDO вследствие многократного варьирования
Зелеев, М.Х., Спирихин, Л.В., Насибуллин, Р.С., Косарева, Д.И.   +3 more
core   +1 more source

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

Advanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye   +12 more
wiley   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

Clearance of surfactant phosphatidylcholine from adult rabbit lungs

, 1988
Rabbits were given various doses of rabbit surfactant and treatment doses of approximately 100 mg/kg body wt of calf surfactant and Surfactant TA by tracheal injection.
A. Jobe, A. Pettenazzo, M. Ikegami, S. Seidner   +3 more
core   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Comparative Analysis of Biological Sphingolipids with Glycerophospholipids and Diacylglycerol by LC-MS/MS

Metabolites, 2014
Liquid chromatography-electrospray ionization mass spectrometry (LC-MS) is an effective and popular technique used in lipid metabolomic studies. Although many LC-MS methods enabling the determination of sphingolipid molecular species have been reported,
Hideo Ogiso, Makoto Taniguchi, Shinichi Araya, Shinya Aoki, Lusi Oka Wardhani, Yuka Yamashita, Yoshibumi Ueda, Toshiro Okazaki   +7 more
doaj   +1 more source

Theoretical Considerations and the Microelectrophoresis Experiment on the Influence of Selected Chaotropic Anions on Phosphatidylcholine Membrane Surface Charge Density

Molecules, 2019
Influence of sodium salts of selected chaotropic anions from the Hofmeister series (NaCl, NaBr, NaNO3, NaI) on the surface charge density of phosphatidylcholine membranes was studied.
Joanna Kotyńska, Monika Naumowicz
doaj   +1 more source

Differential miscibility properties of various phosphatidylcholine/lysophosphatidylcholine mixtures

, 1980
Using enthalphy data from differential scanning calorimetry experiments and 13C-NMR linewidths of specifically (N-Me-13C)-labelled lipids, the miscibility properties of phosphatidylcholines and lysophosphatidylcholines in liposomal dispersions have been ...
Gier, J. de, Echteld, C.J.A. van, Kruijff, B. de   +2 more
core  

Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues

Journal of Lipid Research, 2005
Lysosomal phospholipase A2 (LPLA2) is an acidic phospholipase that is highly expressed in alveolar macrophages and that may play a role in the catabolism of pulmonary surfactant.
Miki Hiraoka, Akira Abe, James A. Shayman   +2 more
doaj   +1 more source