Results 11 to 20 of about 188,850 (296)

BIOSYNTHESIS OF PHOSPHATIDYLINOSITOL [PDF]

Annals of the New York Academy of Sciences, 1970
Interest in our laboratory in the inositol lipids derives from the presence of relatively high amounts of phosphatidylinositol phosphate (PhIP) and phosphatidylinositol diphosphate (PhIPP) in excitable tissue. It was with this relationship in mind that we embarked on a study of biosynthetic pathways of inositol lipids several years ago. A first step in
Agranoff, Bernard W., Benjamin, Joyce A., Hajra, Amiya K.   +2 more
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Phosphatidylinositol 4-kinases [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1998
Polyphosphoinositides are involved in many signal transduction pathways in eukaryotic cells. The first committed step is catalysed by phosphatidylinositol 4‐kinase leading to the formation of phosphatidylinositol 4‐phosphate. In the last four years, ten cDNA molecules have been cloned which code isoforms of phosphatidylinositol 4‐kinase; some of which ...
Ludwig M. G. Heilmeyer, Thor Gehrmann
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Function of Phosphatidylinositol in Mycobacteria [PDF]

Journal of Biological Chemistry, 2005
Phosphatidylinositol (PI) is an abundant phospholipid in the cytoplasmic membrane of mycobacteria and the precursor for more complex glycolipids, such as the PI mannosides (PIMs) and lipoarabinomannan (LAM). To investigate whether the large steady-state pools of PI and apolar PIMs are required for mycobacterial growth, we have generated a Mycobacterium
Helen Billman-Jacobe, Yasu S. Morita, Ruth E. Haites, Malcolm J. McConville   +3 more
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Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells

Journal of Lipid Research, 2006
Maturation of fetal alveolar type II epithelial cells in utero is characterized by specific changes to lung surfactant phospholipids. Here, we quantified the effects of hormonal differentiation in vitro on the molecular specificity of cellular and ...
Anthony D. Postle, Linda W. Gonzales, Wolfgang Bernhard, Graeme T. Clark, Marye H. Godinez, Rodolfo I. Godinez, Philip L. Ballard   +6 more
doaj   +1 more source

Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging

Frontiers in Aging, 2022
The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman disease and cholesteryl ester storage disease.
Lea Hänschke, Christoph Heier, Christoph Heier, Christoph Heier, Santiago José Maya Palacios, Huseyin Erdem Özek, Christoph Thiele, Reinhard Bauer, Ronald P. Kühnlein, Ronald P. Kühnlein, Ronald P. Kühnlein, Margret H. Bülow   +11 more
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Study of the transfer of phospholipids from the endoplasmic reticulum to the outer and inner mitochondrial membranes

Journal of Lipid Research, 1971
Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
doaj   +1 more source

Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids

Journal of Lipid Research, 2007
Glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins is the most complex and metabolically expensive of the lipid posttranslational modifications described to date.
Orlean Peter, Anant K. Menon
doaj   +1 more source

Trehalose Contributes to Gamma-Linolenic Acid Accumulation in Cunninghamella echinulata Based on de Novo Transcriptomic and Lipidomic Analyses

Frontiers in Microbiology, 2018
Gamma-linolenic acid (GLA) is essential for the well-being of humans and other animals. People may lack GLA because of aging or diseases, and thus, dietary supplements or medical reagents containing GLA-enriched lipids are in demand.
Shue Li, Qiang Yue, Shuai Zhou, Jing Yan, Xiaoyu Zhang, Fuying Ma, Fuying Ma   +6 more
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Genomic conservation and putative downstream functionality of the phosphatidylinositol signalling pathway in the cnidarian-dinoflagellate symbiosis

Frontiers in Microbiology, 2023
The mutualistic cnidarian–dinoflagellate symbiosis underpins the evolutionary success of stony corals and the persistence of coral reefs. However, a molecular understanding of the signalling events that lead to the successful establishment and ...
Immy A. Ashley, Sheila A. Kitchen, Lucy M. Gorman, Arthur R. Grossman, Clinton A. Oakley, David J. Suggett, Virginia M. Weis, Sabrina L. Rosset, Simon K. Davy   +8 more
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Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
A. J. Letcher, D. J. Lander, Robin F. Irvine, Alan P. Dawson, Alan Musgrave, Bjørn K. Drøbak   +5 more
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