Results 11 to 20 of about 387,101 (335)

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity

Frontiers in Molecular Biosciences, 2021
Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States per year.
Karen M. Henkels, Kristen M. Rehl, Kwang-jin Cho   +2 more
doaj   +1 more source

Genetic Analysis and Molecular Mapping of the Quantitative Trait Loci Governing Low Phytic Acid Content in a Novel LPA Rice Mutant, PLM11

Plants, 2020
Breeding rice varieties with a low phytic acid (LPA) content is an effective strategy to overcome micronutrient deficiency in a population which consume rice as a staple food.
Prem Chand Gyani, Haritha Bollinedi, Subbaiyan Gopala Krishnan, Kunnummal Kurungara Vinod, Archana Sachdeva, Prolay Kumar Bhowmick, Ranjith Kumar Ellur, Mariappan Nagarajan, Ashok Kumar Singh   +8 more
doaj   +1 more source

Phosphatidylcholine Cation—Tyrosine π Complexes: Motifs for Membrane Binding by a Bacterial Phospholipase C

Molecules, 2022
Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes are a virulence factor in many Gram-positive organisms. The specific activity of the Bacillus thuringiensis PI-PLC is significantly increased by adding phosphatidylcholine (PC) to vesicles ...
Mary F. Roberts, Anne Gershenson, Nathalie Reuter   +2 more
doaj   +1 more source

Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug

Pharmaceutics, 2021
Previously, a liposomal formulation of a chemotherapeutic agent melphalan (Mlph) incorporated in a fluid lipid bilayer of natural phospholipids in the form of dioleoylglyceride ester (MlphDG) was developed and the antitumor effect was confirmed in mouse ...
Daria Tretiakova, Irina Le-Deigen, Natalia Onishchenko, Judith Kuntsche, Elena Kudryashova, Elena Vodovozova   +5 more
doaj   +1 more source

BIOSYNTHESIS OF PHOSPHATIDYLINOSITOL [PDF]

Annals of the New York Academy of Sciences, 1970
Interest in our laboratory in the inositol lipids derives from the presence of relatively high amounts of phosphatidylinositol phosphate (PhIP) and phosphatidylinositol diphosphate (PhIPP) in excitable tissue. It was with this relationship in mind that we embarked on a study of biosynthetic pathways of inositol lipids several years ago. A first step in
Agranoff, Bernard W., Benjamin, Joyce A., Hajra, Amiya K.   +2 more
openaire   +3 more sources

The recruitment and activation of phosphatidylinositol 4-phosphate 5-kinases α critically regulate CD28-dependent signaling responses [PDF]

, 2013
CD28 costimulatory receptor is a crucial determinant of the outcome of T lymphocyte activation. The engagement of CD28 by its natural ligands, B7.1/CD80 or B7.2/CD86, expressed on the surface of professional APC, lowers T cell receptor (TCR) activation ...
Camperio, Cristina, Capuano, Cristina, Caristi, S., Galandrini, R., Muscolini, Michela, Piccolella, Enza, Tuosto, Loretta   +6 more
core   +1 more source

Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]

, 1994
. Lipoprotein lipase (LPL) and glycolipidanchored cAMP-binding ectoprotein (Gcel) are modified by glycosyl-phosphatidylinositol (GPI) in rat adipocytes, however, the linkage is potentially unstable. Incubation of the cells with either insulin (0.1-30 nM)
Bandlow, Wolfhard, Dearey, Elisabeth Ann, Korndörfer, Andrea, Müller, Günter   +3 more
core   +3 more sources

Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids

Journal of Lipid Research, 2007
Glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins is the most complex and metabolically expensive of the lipid posttranslational modifications described to date.
Orlean Peter, Anant K. Menon
doaj   +1 more source

Combinations of idelalisib with rituximab and/or bendamustine in patients with recurrent indolent non-Hodgkin lymphoma [PDF]

, 2016
Key Points Combining phosphatidylinositol-3-kinase δ inhibition with rituximab, bendamustine, or both is feasible and active in relapsed iNHL.
Barrientos, Jacqueline C., Boccia, Ralph V., Boyd, Thomas E., Coutre, Steven E., de Vos, Sven, Flinn, Ian W., Fowler, Nathan H., Furman, Richard R., Godfrey, Wayne R., Kim, Yeonhee, Leonard, John P., Rai, Kanti R., Schreeder, Marshall T., Sharman, Jeff P., Wagner-Johnston, Nina D.   +14 more
core   +2 more sources