Results 1 to 10 of about 154,752 (304)
Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. [PDF]
PLoS One, 2010 Poxvirus morphogenesis is a complex process that involves the successive wrapping of the virus in host cell membranes. We screened by plaque assay a focused library of kinase inhibitors for those that caused a reduction in viral growth and identified ...
McNulty S +9 more
europepmc +2 more sources
Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. [PDF]
PLoS One, 2012 The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in many biological processes, including cell cycle progression, cell growth, survival, actin rearrangement and migration, and intracellular vesicular transport.
Hou H +9 more
europepmc +2 more sources
Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer
Frontiers in Oncology, 2023 Phosphoinositides, a small group of lipids found in all cellular membranes, have recently garnered heightened attention due to their crucial roles in diverse biological processes and different diseases. Among these, phosphatidylinositol 4,5-bisphosphate (
Yue Jin, Jian Xue
doaj +1 more source
Phosphatidylinositol 3-Kinase [PDF]
Pancreas, 2016 Even though a strong association between inflammation and cancer has been widely accepted, the underlying precise molecular mechanisms are still largely unknown. A complex signaling network between tumor and stromal cells is responsible for the infiltration of inflammatory cells into the cancer microenvironment.
Birtolo, Chiara +4 more
+7 more sources
Frontiers in Pharmacology, 2021 Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood.
Olivier Preynat-Seauve +11 more
doaj +1 more source
Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]
, 2004 Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core +2 more sources
Identification of Key Phospholipids That Bind and Activate Atypical PKCs
Biomedicines, 2021 PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with ...
Suresh Velnati +10 more
doaj +1 more source
Phosphatidylinositol 3‐monophosphate: A novel actor in thrombopoiesis and thrombosis
Research and Practice in Thrombosis and Haemostasis, 2020 Phosphoinositides are lipid second messengers regulating in time and place the formation of protein complexes involved in the control of intracellular signaling, vesicular trafficking, and cytoskeleton/membrane dynamics.
Colin Valet +5 more
doaj +1 more source
Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
Frontiers in Cellular and Infection Microbiology, 2019 Phosphatidylinositol (PtdIns) metabolism is indispensable in eukaryotes. Phosphoinositides (PIs) are phosphorylated derivatives of PtdIns and consist of seven species generated by reversible phosphorylation of the inositol moieties at the positions 3, 4,
Kumiko Nakada-Tsukui +4 more
doaj +1 more source
PI(3,4)P2 Signaling in Cancer and Metabolism
Frontiers in Oncology, 2020 The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer metabolism, and cancer cell proliferation.
Luca Gozzelino +4 more
doaj +1 more source