Results 1 to 10 of about 405,250 (376)
Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. [PDF]
PLoS ONE, 2012 The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in many biological processes, including cell cycle progression, cell growth, survival, actin rearrangement and migration, and intracellular vesicular transport.
Heli Hou +8 more
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Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. [PDF]
PLoS ONE, 2010 Poxvirus morphogenesis is a complex process that involves the successive wrapping of the virus in host cell membranes. We screened by plaque assay a focused library of kinase inhibitors for those that caused a reduction in viral growth and identified ...
Shannon McNulty +9 more
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Phosphatidylinositol 3‐kinases in tumor progression [PDF]
European Journal of Biochemistry, 2001 Many cellular processes have been identified in which phosphatidylinositol 3‐kinase has a key regulatory function. As an oncogene, it is also involved in the development of cancer. The transformation and progression of normal cells towards an advanced stage tumor and/or towards metastatic lesions involves a complex series of events, including genetic ...
Roymans, D., Slegers, Herman
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Phosphatidylinositol 3-Kinases.
membrane, 1996 Phosphatidylinositol 3-kinase (PI 3-kinase), which is responsible for phosphorylating phosphatidylinositol (PI), PI(4)P, and PI(4, 5)P2, is a crucial signaling intermediate in the regulation of various biological functions. The site of the lipid kinase action has not been well defined.
Takahiro Suzuki, Osamu Hazeki, Michio Ui
openaire +3 more sources
Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas [PDF]
Haematologica, 2013 Peripheral T-cell lymphomas are very aggressive hematologic malignancies for which there is no targeted therapy. New, rational approaches are necessary to improve the very poor outcome in these patients.
Esperanza Martín-Sánchez +19 more
doaj +2 more sources
Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer
Frontiers in Oncology, 2023 Phosphoinositides, a small group of lipids found in all cellular membranes, have recently garnered heightened attention due to their crucial roles in diverse biological processes and different diseases. Among these, phosphatidylinositol 4,5-bisphosphate (
Yue Jin, Jian Xue
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Phosphatidylinositol 3-Kinase [PDF]
Pancreas, 2016 Even though a strong association between inflammation and cancer has been widely accepted, the underlying precise molecular mechanisms are still largely unknown. A complex signaling network between tumor and stromal cells is responsible for the infiltration of inflammatory cells into the cancer microenvironment.
Birtolo, Chiara +4 more
+7 more sources
Frontiers in Pharmacology, 2021 Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood.
Olivier Preynat-Seauve +11 more
doaj +1 more source
Identification of Key Phospholipids That Bind and Activate Atypical PKCs
Biomedicines, 2021 PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with ...
Suresh Velnati +10 more
doaj +1 more source
Phosphatidylinositol 3‐monophosphate: A novel actor in thrombopoiesis and thrombosis
Research and Practice in Thrombosis and Haemostasis, 2020 Phosphoinositides are lipid second messengers regulating in time and place the formation of protein complexes involved in the control of intracellular signaling, vesicular trafficking, and cytoskeleton/membrane dynamics.
Colin Valet +5 more
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