Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates [PDF]
MethodsX, 2021 Single molecule localization microscopy (SMLM) provided an unprecedented insight into the sub-nuclear organization of proteins and nucleic acids but apart from the nuclear envelope the role of the nuclear lipids in the functional organization of the cell
Peter Hoboth +4 more
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Quantitative structural characterization of phosphatidylinositol phosphates from biological samples [PDF]
Journal of Lipid Research, 2017 The aspects of cellular metabolism controlled by phosphatidylinositol phosphates (PtdInsPs) have been broadly expanded, and these phospholipids have drawn tremendous attention as pleiotropic signaling molecules.
Su Hee Kim +8 more
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Acutely Modifying Phosphatidylinositol Phosphates on Endolysosomes Using Chemically Inducible Dimerization Systems [PDF]
Bio-ProtocolPhosphoinositides are rare membrane lipids that mediate cell signaling and membrane dynamics. PI(4)P and PI(3)P are two major phosphoinositides crucial for endolysosomal functions and dynamics, making them the lipids of interest in many studies.
Wei Sheng Yap, Peter Kim, Maxime Boutry
doaj +2 more sources
Inositol metabolism as a broad-spectrum antiviral target [PDF]
Frontiers in MicrobiologyInositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, formation of ...
Kunlakanya Jitobaom +3 more
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VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. [PDF]
Sci Rep, 2019 AbstractIn cyanobacteria and plants, VIPP1 plays crucial roles in the biogenesis and repair of thylakoid membrane protein complexes and in coping with chloroplast membrane stress. In chloroplasts, VIPP1 localizes in distinct patterns at or close to envelope and thylakoid membranes. In vitro, VIPP1 forms higher-order oligomers of >1 MDa that organize
Theis J +7 more
europepmc +8 more sources
Metabolomic and lipidomic changes in heat-stressed chickpea seeds [PDF]
Frontiers in Plant ScienceExtreme climate induced heat stress during the reproductive phase significantly reduces yield and seed quality in chickpea, a vital cool-season pulse crop.
Uday Chand Jha +5 more
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Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi [PDF]
mBioInositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini +9 more
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Recognizing Phosphatidylinositol 3-Phosphate [PDF]
Cell, 2001 Phosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins by binding to FYVE and PX domains. New structures of these domains complexed with the phosphoinositide headgroup show how interactions with phosphate and hydroxyl groups differentiate this lipid from all others.
Misra, Saurav +2 more
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Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Phagocytes are key to innate immunity, as they ingest, kill, and degrade foreign particles, such as microbes. Particle uptake results in the formation of phagosomes that eventually fuse with lysosomes, the main degradative compartments in cells.
Jeschke, Andreas +10 more
openaire +3 more sources
Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity. [PDF]
PLoS ONE, 2016 Myotubularin-related protein 1 (MTMR1) is a phosphatase that belongs to the tyrosine/dual-specificity phosphatase superfamily. MTMR1 has been shown to use phosphatidylinositol 3-monophosphate (PI(3)P) and/or phosphatidylinositol 3,5-bisphosphate (PI(3,5 ...
Seoung Min Bong +9 more
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