Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates [PDF]
MethodsX, 2021 Single molecule localization microscopy (SMLM) provided an unprecedented insight into the sub-nuclear organization of proteins and nucleic acids but apart from the nuclear envelope the role of the nuclear lipids in the functional organization of the cell
Peter Hoboth +4 more
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Quantitative structural characterization of phosphatidylinositol phosphates from biological samples [PDF]
Journal of Lipid Research, 2017 The aspects of cellular metabolism controlled by phosphatidylinositol phosphates (PtdInsPs) have been broadly expanded, and these phospholipids have drawn tremendous attention as pleiotropic signaling molecules.
Su Hee Kim +8 more
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Acutely Modifying Phosphatidylinositol Phosphates on Endolysosomes Using Chemically Inducible Dimerization Systems [PDF]
Bio-ProtocolPhosphoinositides are rare membrane lipids that mediate cell signaling and membrane dynamics. PI(4)P and PI(3)P are two major phosphoinositides crucial for endolysosomal functions and dynamics, making them the lipids of interest in many studies.
Wei Sheng Yap, Peter Kim, Maxime Boutry
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Inositol metabolism as a broad-spectrum antiviral target [PDF]
Frontiers in MicrobiologyInositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, formation of ...
Kunlakanya Jitobaom +3 more
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Metabolomic and lipidomic changes in heat-stressed chickpea seeds [PDF]
Frontiers in Plant ScienceExtreme climate induced heat stress during the reproductive phase significantly reduces yield and seed quality in chickpea, a vital cool-season pulse crop.
Uday Chand Jha +5 more
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VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. [PDF]
Sci Rep, 2019 Theis J +7 more
europepmc +3 more sources
Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi [PDF]
mBioInositol phosphates are involved in a myriad of biological roles and activities such as Ca2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity.
Mayara S. Bertolini +9 more
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EFR3A, an Intriguing Gene, and Protein with a Scaffolding Function [PDF]
CellsThe EFR3 (Eighty-Five Requiring 3) protein and its homologs are rather poorly understood eukaryotic plasma membrane peripheral proteins. They belong to the armadillo-like family of superhelical proteins.
Magdalena Trybus +3 more
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Nanodisc single-molecule pulldown to study lipid-protein interactions [PDF]
Journal of Lipid ResearchBeyond serving structural roles in the cell membrane, many phospholipids, including phosphatidylinositol phosphates (PIPs), are key signaling molecules that regulate a myriad of cellular processes.
Adriana Reyes-Ordoñez +4 more
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Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity. [PDF]
PLoS ONE, 2016 Myotubularin-related protein 1 (MTMR1) is a phosphatase that belongs to the tyrosine/dual-specificity phosphatase superfamily. MTMR1 has been shown to use phosphatidylinositol 3-monophosphate (PI(3)P) and/or phosphatidylinositol 3,5-bisphosphate (PI(3,5 ...
Seoung Min Bong +9 more
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