Results 11 to 20 of about 13,924 (256)

Plasma Membrane Phosphatidylinositol-4-Phosphate Is Not Necessary for Candida albicans Viability yet Is Key for Cell Wall Integrity and Systemic Infection

mBio, 2022
Phosphatidylinositol phosphates are key phospholipids with a range of regulatory roles, including membrane trafficking and cell polarity. Phosphatidylinositol-4-phosphate [PI(4)P] at the Golgi apparatus is required for the budding-to-filamentous-growth ...
Rocio Garcia-Rodas, Hayet Labbaoui, François Orange, Norma Solis, Oscar Zaragoza, Scott G. Filler, Martine Bassilana, Robert A. Arkowitz   +7 more
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Lipid Polarization during Cytokinesis

Cells, 2022
The plasma membrane of eukaryotic cells is composed of a large number of lipid species that are laterally segregated into functional domains as well as asymmetrically distributed between the outer and inner leaflets.
Govind Kunduri, Usha Acharya, Jairaj K. Acharya   +2 more
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Signaling roles of phosphoinositides in the retina

Journal of Lipid Research, 2021
The field of phosphoinositide signaling has expanded significantly in recent years. Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal signaling molecules that directly interact with membrane proteins or with ...
Raju V.S. Rajala
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Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers

Cells, 2021
The genetic code that dictates how nucleic acids are translated into proteins is well known, however, the code through which proteins recognize membranes remains mysterious.
Troy A. Kervin, Michael Overduin
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A conserved function in phosphatidylinositol metabolism for mammalian Vps13 family proteins. [PDF]

PLoS ONE, 2015
The Vps13 protein family is highly conserved in eukaryotic cells. In humans, mutations in the gene encoding the family member VPS13A lead to the neurodegenerative disorder chorea-acanthocytosis.
Jae-Sook Park, Simon Halegoua, Shosei Kishida, Aaron M Neiman   +3 more
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Myoinositol in Autoimmune Thyroiditis

Frontiers in Endocrinology, 2022
Myoinositol (Myo) is an isoform of inositol, a cyclic polyol with 6 hydroxyl groups. Myo is mainly derived from dietary intake while its endogenous production is generated from glucose by enzymatic reactions.
Sabrina Rosaria Paparo, Silvia Martina Ferrari, Armando Patrizio, Giusy Elia, Francesca Ragusa, Chiara Botrini, Eugenia Balestri, Fabrizio Guarneri, Salvatore Benvenga, Salvatore Benvenga, Salvatore Benvenga, Alessandro Antonelli, Poupak Fallahi   +12 more
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Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

Molecules, 2020
Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously ...
Catherine A. Tindall, Sebastian Dommel, Veronika Riedl, David Ulbricht, Stefanie Hanke, Norbert Sträter, John T. Heiker   +6 more
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Electrostatic Interaction Between NS1 and Negatively Charged Lipids Contributes to Flavivirus Replication Organelles Formation

Frontiers in Microbiology, 2021
Flavivirus replication occurs in membranous replication compartments, also known as replication organelles (ROs) derived from the host ER membrane. Our previous study showed that the non-structural (NS) protein 1 (NS1) is the essential factor for RO ...
Yali Ci, Yali Ci, Yang Yang, Yang Yang, Caimin Xu, Caimin Xu, Cheng-Feng Qin, Lei Shi, Lei Shi   +8 more
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MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

Cell Reports, 2014
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A. Sehon, Robert W. Marquis, John Bertin, Peter J. Gough, Savvas Savvides, Jean-Claude Martinou, Mathieu J.M. Bertrand, Peter Vandenabeele   +15 more
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Inorganic polyphosphate modulates TRPM8 channels. [PDF]

PLoS ONE, 2009
Polyphosphate (polyP) is an inorganic polymer built of tens to hundreds of phosphates, linked by high-energy phosphoanhydride bonds. PolyP forms complexes and modulates activities of many proteins including ion channels.
Eleonora Zakharian, Baskaran Thyagarajan, Robert J French, Evgeny Pavlov, Tibor Rohacs   +4 more
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