Results 11 to 20 of about 12,824 (233)
mBio, 2022 Phosphatidylinositol phosphates are key phospholipids with a range of regulatory roles, including membrane trafficking and cell polarity. Phosphatidylinositol-4-phosphate [PI(4)P] at the Golgi apparatus is required for the budding-to-filamentous-growth ...
Rocio Garcia-Rodas +7 more
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Lipid Polarization during Cytokinesis
Cells, 2022 The plasma membrane of eukaryotic cells is composed of a large number of lipid species that are laterally segregated into functional domains as well as asymmetrically distributed between the outer and inner leaflets.
Govind Kunduri +2 more
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Signaling roles of phosphoinositides in the retina
Journal of Lipid Research, 2021 The field of phosphoinositide signaling has expanded significantly in recent years. Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal signaling molecules that directly interact with membrane proteins or with ...
Raju V.S. Rajala
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Structural Basis for Phosphatidylinositol-Phosphate Biosynthesis [PDF]
Biophysical Journal, 2015 AbstractPhosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates and proteins to outer cellular membranes. The defining step in phosphatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction, and either inositol
Belcher Dufrisne, Meagan L. +10 more
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Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. [PDF]
Proceedings of the National Academy of Sciences, 1991 We have synthesized phosphatidylinositol 3-phosphate from phosphatidylinositol 4-phosphate by using diisopropylcarbodiimide to promote migration of the 4-phosphate via a cyclic phosphodiester intermediate. The product was isolated by a thin-layer chromatographic method that depends on the ability of phosphatidylinositol 4-phosphate, but not ...
J P, Walsh, K K, Caldwell, P W, Majerus
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A conserved function in phosphatidylinositol metabolism for mammalian Vps13 family proteins. [PDF]
PLoS ONE, 2015 The Vps13 protein family is highly conserved in eukaryotic cells. In humans, mutations in the gene encoding the family member VPS13A lead to the neurodegenerative disorder chorea-acanthocytosis.
Jae-Sook Park +3 more
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Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers
Cells, 2021 The genetic code that dictates how nucleic acids are translated into proteins is well known, however, the code through which proteins recognize membranes remains mysterious.
Troy A. Kervin, Michael Overduin
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Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)
Molecules, 2020 Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously ...
Catherine A. Tindall +6 more
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Myoinositol in Autoimmune Thyroiditis
Frontiers in Endocrinology, 2022 Myoinositol (Myo) is an isoform of inositol, a cyclic polyol with 6 hydroxyl groups. Myo is mainly derived from dietary intake while its endogenous production is generated from glucose by enzymatic reactions.
Sabrina Rosaria Paparo +12 more
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Frontiers in Microbiology, 2021 Flavivirus replication occurs in membranous replication compartments, also known as replication organelles (ROs) derived from the host ER membrane. Our previous study showed that the non-structural (NS) protein 1 (NS1) is the essential factor for RO ...
Yali Ci +8 more
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