Phosphatidylinositol 3-phosphate is generated in phagosomal membranes [PDF]
Current Biology, 2001 Phagocytic cells such as neutrophils and macrophages engulf and destroy invading microorganisms. After internalization, material captured within the phagosomal membrane is destroyed by a complex process of coordinated delivery of digestive enzymes and reactive oxygen species.
Chris D. Ellson +6 more
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VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. [PDF]
Sci Rep, 2019 AbstractIn cyanobacteria and plants, VIPP1 plays crucial roles in the biogenesis and repair of thylakoid membrane protein complexes and in coping with chloroplast membrane stress. In chloroplasts, VIPP1 localizes in distinct patterns at or close to envelope and thylakoid membranes. In vitro, VIPP1 forms higher-order oligomers of >1 MDa that organize
Theis J +7 more
europepmc +8 more sources
Recognizing Phosphatidylinositol 3-Phosphate [PDF]
Cell, 2001 Phosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins by binding to FYVE and PX domains. New structures of these domains complexed with the phosphoinositide headgroup show how interactions with phosphate and hydroxyl groups differentiate this lipid from all others.
James H. Hurley +2 more
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Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Phagocytes are key to innate immunity, as they ingest, kill, and degrade foreign particles, such as microbes. Particle uptake results in the formation of phagosomes that eventually fuse with lysosomes, the main degradative compartments in cells.
Tamas Balla +11 more
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Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. [PDF]
Proceedings of the National Academy of Sciences, 1991 We have synthesized phosphatidylinositol 3-phosphate from phosphatidylinositol 4-phosphate by using diisopropylcarbodiimide to promote migration of the 4-phosphate via a cyclic phosphodiester intermediate. The product was isolated by a thin-layer chromatographic method that depends on the ability of phosphatidylinositol 4-phosphate, but not ...
James P. Walsh +2 more
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Structural Basis for Phosphatidylinositol-Phosphate Biosynthesis [PDF]
Biophysical Journal, 2015 AbstractPhosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates and proteins to outer cellular membranes. The defining step in phosphatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction, and either inositol
Wayne A. Hendrickson +10 more
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Magnesium Contact Ions Stabilize the Tertiary Structure of Transfer RNA: Electrostatics Mapped by Two-Dimensional Infrared Spectra and Theoretical Simulations [PDF]
J. Phys. Chem. B 2021, 125, 740-747, 2021 Ions interacting with hydrated RNA play a central role in defining its secondary and tertiary structure. While spatial arrangements of ions, water molecules, and phosphate groups have been inferred from X-ray studies, the role of electrostatic and other noncovalent interactions in stabilizing compact folded RNA structures is not fully understood at the
arxiv +1 more source
A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana. [PDF]
, 2020 In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood.
Armbruster, Ute +6 more
core +2 more sources
A conserved function in phosphatidylinositol metabolism for mammalian Vps13 family proteins. [PDF]
PLoS ONE, 2015 The Vps13 protein family is highly conserved in eukaryotic cells. In humans, mutations in the gene encoding the family member VPS13A lead to the neurodegenerative disorder chorea-acanthocytosis.
Jae-Sook Park +3 more
doaj +1 more source
Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers
Cells, 2021 The genetic code that dictates how nucleic acids are translated into proteins is well known, however, the code through which proteins recognize membranes remains mysterious.
Troy A. Kervin, Michael Overduin
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