Results 151 to 160 of about 77,486 (386)

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source

Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver

Journal of Lipid Research, 2021
: Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 (MBOAT7).
Mingfeng Xia, Preethi Chandrasekaran, Shunxing Rong, Xiaorong Fu, Matthew A. Mitsche   +4 more
doaj  

Biosynthesis of phosphatidylinositol in rat brain [PDF]

, 1963
W. Thompson, KP STRICKLAND, R. J. Rossiter   +2 more
openalex   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Analysis of triacylglycerol and phospholipid sn‐positional isomers by liquid chromatographic and mass spectrometric methodologies

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Analysis of triacylglycerol (TG) and phospholipid sn‐positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods.
Mikael Fabritius, Baoru Yang
wiley   +1 more source

Mass spectrometry–based lipidomics of oral squamous cell carcinoma tissue reveals aberrant cholesterol and glycerophospholipid metabolism — A Pilot study

Translational Oncology, 2020
Lipid metabolic reprogramming is one hallmark of cancer. Lipid metabolism is regulated by numerous enzymes, many of which are targeted by several drugs on the market.
Amy Dickinson, Mayank Saraswat, Sakari Joenväärä, Rahul Agarwal, Daniel Jyllikoski, Tommy Wilkman, Antti Mäkitie, Suvi Silén   +7 more
doaj  

The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain [PDF]

, 1978
Robin F. Irvine, N Hemington, R. M. C. Dawson   +2 more
openalex   +1 more source

Protein regulation by phosphatidylinositol lipids

Chemistry & Biology, 1995
Phosphatidylinositol lipids are best known as a source of the second messengers inositol trisphosphate and diacylglycerol. Some phosphatidylinositol lipids may directly regulate cytoskeletal events, however. To understand the role of lipids in signaling, help from both synthetic chemists and physical chemists is needed.
openaire   +3 more sources

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

Advanced Science, EarlyView.
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen, Xiaoman Zhu, Michael Mingze Lu, Qingjian Ou, Xueying Wang, Zhenzhen Zhao, Qi Shen, Qian Wang, Zhe Wang, Jing‐Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Xiaoliang Jin, Yanlong Bi, Lixia Lu, Guo‐Tong Xu, Haibin Tian   +19 more
wiley   +1 more source

Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish

Disease Models & Mechanisms, 2011
SUMMARY The vertebrate heart is one of the first organs to form, and its early function and morphogenesis are crucial for continued embryonic development.
Joshua D. Wythe, Michael J. Jurynec, Lisa D. Urness, Christopher A. Jones, M. Khaled Sabeh, Andreas A. Werdich, Mariko Sato, H. Joseph Yost, David J. Grunwald, Calum A. MacRae, Dean Y. Li   +10 more
doaj   +1 more source