Results 151 to 160 of about 79,046 (379)

Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria [PDF]

, 2007
Marcelo E. Guerin, Jana Korduláková, Francis Schaeffer, Zuzana Svetlíková, Alejandro Buschiazzo, David Giganti, Brigitte Gicquel, Katarı́na Mikus̃ová, Mary Jackson, Pedro M. Alzari   +9 more
openalex   +1 more source

Leishmania tarentolae: taxonomic classification and its application as a promising biotechnological expression host

, 2019
In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications.
Klatt, S., Konthur, Z., Maslov, D., Simpson, L.   +3 more
core   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Hydrodynamics of Diffusion in Lipid Membrane Simulations

, 2018
By performing molecular dynamics simulations with up to 132 million coarse-grained particles in half-micron sized boxes, we show that hydrodynamics quantitatively explains the finite-size effects on diffusion of lipids, proteins, and carbon nanotubes in ...
Hummer, Gerhard, Köfinger, Jürgen, Vögele, Martin   +2 more
core   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

On the functional ordering of biomembranes : Implications for drug binding [PDF]

, 2010
Cells are packed with membrane structures, defining the inside and outside, and the different subcellular compartments. These membranes consisting mainly of phospholipids have a variety of functions in addition to providing a permeability barrier for ...
Parry, Mikko
core  

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Faculty Opinions recommendation of Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization.

, 2019
Eamonn J. Dickson
openalex   +2 more sources

Phosphatidylinositol 4,5‐bisphosphate (PIP₂) modulates afterhyperpolarizations in oxytocin neurons of the supraoptic nucleus [PDF]

, 2017
Matthew K. Kirchner, Robert C. Foehring, Lie Wang, Giri K Chandaka, Joseph C. Callaway, William E. Armstrong   +5 more
openalex   +1 more source

Biocompatible Magnetopyroelectric Composite Films for Cell Stimulation

Advanced Science, EarlyView.
Magnetopyroelectric films couple Fe3O4 nanoparticles with pyroelectric P(VDF‐TrFE) to turn alternating magnetic fields into controlled heat and pyroelectric currents. This heavy‐metal free platform safely boosts neural progenitor cells differentiation via synergistic thermal and pyroelectrical cues, engages AKT and calcium pathways, and opens practical
Hao Ye, Joaquin Llacer‐Wintle, Semih Sevim, Elric Zhang, Denis von Arx, Lukas Hertle, Martina Accursi, Minsoo Kim, Josep Puigmartí‐Luis, Bradley J. Nelson, Xiang‐Zhong Chen, Salvador Pané   +11 more
wiley   +1 more source