Results 211 to 220 of about 79,046 (379)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Human skeletal muscle disuse atrophy has profound and negative effects on the muscle metabolome and lipidome. [PDF]

Am J Physiol Endocrinol Metab
Kilroe SP, Von Ruff ZD, Arentson-Lantz EJ, Romsdahl TB, Linares JJ, Kalenta H, Marchant ED, Volpi E, Paddon-Jones D, Russell WK, Rasmussen BB.   +10 more
europepmc   +1 more source

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

, 2005
Yufeng Yang, Stephan Gehrke, Md. Emdadul Haque, Yuzuru Imai, Jon C. Kosek, Lichuan Yang, M. Flint Beal, Isao Nishimura, Kazumasa Wakamatsu, Shosuke Ito, Ryōsuke Takahashi, Bingwei Lu   +11 more
openalex   +2 more sources

Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains

, 2021
Jongyun Myeong, Cheon-Gyu Park, Byung‐Chang Suh, Bertil Hille   +3 more
openalex   +2 more sources

Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.

Journal of Biological Chemistry, 1994
John D. York, P. Majerus
semanticscholar   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Reduced lipid metabolite abundance in human pancreatic cancer and matched serum samples following neoadjuvant FOLFIRINOX treatment. [PDF]

Metabolomics
Amrutkar M, Guttorm SJT, Labori KJ, Rootwelt H, Elgstøen KBP, Gladhaug IP, Verbeke CS.   +6 more
europepmc   +1 more source

Intermittent pH changes suggest acceleration of the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/ protein kinase B (AKT) pathways.

Ryota Nishida (22258400), Tomoaki Fukui (4777479), Kenichi Sawauchi (22258403), Yohei Kumabe (4777482), Hyuma Kondo (22258406), Yuya Yamamoto (667024), Kyohei Takase (22258409), Ryo Yoshikawa (5075996), Takahiro Niikura (344625), Ryosuke Kuroda (735024), Keisuke Oe (344623)   +10 more
openalex   +1 more source

Nerve Growth Factor Restores p53 Function in Pituitary Tumor Cell Lines via trkA-Mediated Activation of Phosphatidylinositol 3-Kinase [PDF]

, 2003
Marco Facchetti, Daniela Uberti, Maurizio Memo, Cristina Missale   +3 more
openalex   +1 more source