Results 251 to 260 of about 77,486 (386)

Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of α‐synuclein aggregates. In Parkinson's disease, increases in monounsaturated fatty acids (MUFA) in phospholipid membranes promote α‐synuclein binding, aggregation, and toxicity ...
Finula I. Isik, YuHong Fu, Russell Pickford, Qi Cheng, Yue Yang, Simon J.G. Lewis, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim   +8 more
wiley   +1 more source

Insights into optimization of oleaginous fungi - genome-scale metabolic reconstruction and analysis of <i>Umbelopsis</i> sp. WA50703. [PDF]

Comput Struct Biotechnol J
Dziurzyński M, Nowak ME, Furman M, Okrasińska A, Pawłowska J, Fondi M.   +5 more
europepmc   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils. [PDF]

, 1983
T Takenawa, Yoshimi Homma, Yuki Nagai
openalex   +1 more source

Chronodisruption that dampens output of the central clock abolishes rhythms in metabolome profiles and elevates acylcarnitine levels in the liver of female rats. [PDF]

Acta Physiol (Oxf)
Arora S, Houdek P, Čajka T, Dočkal T, Sládek M, Sumová A.   +5 more
europepmc   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

Medicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain, Wajiha Arif, Sharjeel Humayun, Nida Shoaib, Saim Mahmood Khan   +4 more
wiley   +1 more source

Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells. [PDF]

, 1987
J J O'Shea, Kevin B. Urdahl, H T Luong, Thomas M. Chused, Lawrence E. Samelson, Richard D. Klausner   +5 more
openalex   +1 more source

Metabolomics of Papanicolaou Tests for the Discovery of Ovarian Cancer Biomarkers. [PDF]

Metabolites
Sah S, Schwiebert EM, Moore SG, Liu Y, Gaul DA, Boylan KLM, Skubitz APN, Fernández FM.   +7 more
europepmc   +1 more source

Phosphatidylinositol-3-Kinase Pathway [PDF]

Journal of Thoracic Oncology, 2012
openaire   +3 more sources

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model

Molecular Nutrition &Food Research, EarlyView.
Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García, Begoña Ayuda‐Durán, Susana González‐Manzano, Celestino Santos‐Buelga, Ana M. González‐Paramás   +4 more
wiley   +1 more source