Results 71 to 80 of about 8,270 (191)

Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling [PDF]

, 2015
© 2015 Mitchell et al. Abstract Background: Mass spectrometry imaging (MSI) is a powerful tool for the study of intact tissue sections. Here, its application to the study of the distribution of lipids in sections of reconstructed living skin equivalents ...
Clench, Malcolm, Donaldson, M., Francese, S., Long, H., Mitchell, C.A.   +4 more
core   +2 more sources

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Phagocytes are key to innate immunity, as they ingest, kill, and degrade foreign particles, such as microbes. Particle uptake results in the formation of phagosomes that eventually fuse with lysosomes, the main degradative compartments in cells.
Jeschke, Andreas, Zehethofer, Nicole, Lindner, Buko, Krupp, Jessica, Schwudke, Dominik, Haneburger, Ina, Jovic, Marko, Backer, Jonathan M, Balla, Tamas, Hilbi, Hubert, Haas, Albert   +10 more
openaire   +3 more sources

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation[S]

Journal of Lipid Research, 2009
Molecular events involved in successful embryo implantation are not well understood. In this study, we used MALDI imaging mass spectrometry (IMS) technologies to characterize the spatial and temporal distribution of phospholipid species associated with ...
Kristin E. Burnum, Dale S. Cornett, Satu M. Puolitaival, Stephen B. Milne, David S. Myers, Susanne Tranguch, H. Alex Brown, Sudhansu K. Dey, Richard M. Caprioli   +8 more
doaj   +1 more source

Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice

Lipids in Health and Disease, 2022
Background Recent findings show that extracellular vesicle constituents can exert short- and long-range biological effects on neighboring cells in the brain, opening an exciting avenue for investigation in the field of neurodegenerative diseases ...
Melissa R. Pergande, Christina Kang, Diann George, Pearl A. Sutter, Stephen J. Crocker, Stephanie M. Cologna, Maria I. Givogri   +6 more
doaj   +1 more source

Characterization of the Lipidome and Biophysical Properties of Membranes from High Five Insect Cells Expressing Mouse P-Glycoprotein

Biomolecules, 2021
The lipid composition of biomembranes influences the properties of the lipid bilayer and that of the proteins. In this study, the lipidome and the lipid/protein ratio of membranes from High Five™ insect cells overexpressing mouse P-glycoprotein was ...
Maria João Moreno, Patrícia Alexandra Teles Martins, Eva F. Bernardino, Biebele Abel, Suresh V. Ambudkar   +4 more
doaj   +1 more source

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

, 2020
A comprehensive characterization of the lipidome from limited starting material remains very challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid chromatography and trapped ion mobility spectrometry (TIMS).
Barsch, A., Brunner, A., Mann, M., Meier, F., Meitei, N., Meyer, S., Schweiger-Hufnagel, U., Sulek, K., Vasilopoulou, C.   +8 more
core   +1 more source

Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients [PDF]

, 2015
There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype.
AG Serrano, AM Fiorenza, Andrew W. Fogarty, CH Oak, D Kong, David A. Barrett, David R. Baldwin, E Wojcik, GL May, H Ulmer, H Yang, Helen L. Barr, J Castro de, J Chee, J Dong, J Liu, JM Poczobutt, K Yanagisawa, K Yang, L Cheng, M Haag, M Hassanein, M Hassanein, M Murphy, MJ Wakelam, MR Wenk, P Brites, R Angelis de, RA Murphy, RA Murphy, RE Smith, RL Keith, RT Sreseli, S Cedres, Srinivasarao Ravipati, WJ Scott, X Gao, X Zeng, Y Guo, YY Tyurina, ZA Fernandis   +40 more
core   +1 more source

Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
R F, Irvine, A J, Letcher, D J, Lander, B K, Drøbak, A P, Dawson, A, Musgrave   +5 more
openaire   +2 more sources

Identification of atypical ether-linked glycerophospholipid species in macrophages by mass spectrometry

Journal of Lipid Research, 2010
A large scale profiling and analysis of glycerophospholipid species in macrophages has facilitated the identification of several rare and atypical glycerophospholipid species.
Pavlina T. Ivanova, Stephen B. Milne, H. Alex Brown   +2 more
doaj   +1 more source

The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development [PDF]

, 2017
Chorioamnionitis is associated with adverse neurodevelopmental outcomes in preterm infants. Ureaplasma spp. are the microorganisms most frequently isolated from the amniotic fluid of women diagnosed with chorioamnionitis.
Barre, F.P.Y., Beeton, Michael L., Cillero-Pastor, B., Gussenhoven, R., Heeren, R.M.A., Jobe, A.H., Kallapur, S.G., Kemp, M.W., Kessels, L., Kramer, B.W., Ophelders, D.R.M.G., Payne, M.S., Rutten, B.P., Spiller, O.B., Stevens, B., Stocks, S.J., Wolfs, T.G.A.M.   +16 more
core   +4 more sources