Results 1 to 10 of about 108,878 (236)

Sensing Phosphatidylserine in Cellular Membranes [PDF]

Sensors, 2011
Phosphatidylserine, a phospholipid with a negatively charged head-group, is an important constituent of eukaryotic cellular membranes. On the plasma membrane, rather than being evenly distributed, phosphatidylserine is found preferentially in the inner ...
Jason G. Kay, Sergio Grinstein
doaj   +4 more sources

Phosphatidylserine transport in Rhnull erythrocytes [PDF]

Blood, 1990
Abstract Phosphatidylserine transport in normal and Rhnull red blood cells was determined by measuring characteristic morphologic changes induced by synthetic phospholipids. Treating normal A+ cells with commercial anti- A antisera, anti-Rho(D) antisera, or with saturating concentrations of purified Rho(D) antibodies had no effect on ...
Smith Re, DL Daleke
openalex   +5 more sources

Control of phosphatidylserine biosynthesis through phosphatidylserine-mediated inhibition of phosphatidylserine synthase I in Chinese hamster ovary cells [PDF]

Proceedings of the National Academy of Sciences, 1998
Phosphatidylserine (PtdSer) synthesis in Chinese hamster ovary (CHO) cells occurs through the exchange of l -serine with the base moiety of phosphatidylcholine or phosphatidylethanolamine. The synthesis is depressed on the addition of PtdSer to the culture medium.
Osamu Kuge, Kazuhide Hasegawa, Kyoko Saito, Masahiro Nishijima   +3 more
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Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles. [PDF]

PLoS Pathogens, 2018
Cell surface receptors for phosphatidylserine contribute to the entry of Ebola virus (EBOV) particles, indicating that the presence of phosphatidylserine in the envelope of EBOV is important for the internalization of EBOV particles.
Asuka Nanbo, Junki Maruyama, Masaki Imai, Michiko Ujie, Yoichiro Fujioka, Shinya Nishide, Ayato Takada, Yusuke Ohba, Yoshihiro Kawaoka   +8 more
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How do necrotic cells expose phosphatidylserine to attract their predators—What’s unique and what’s in common with apoptotic cells

Frontiers in Cell and Developmental Biology, 2023
Phosphatidylserine (PS) is a lipid component of the plasma membrane. It is asymmetrically distributed to the inner leaflet in live cells. In cells undergoing apoptosis, phosphatidylserine is exposed to the outer surfaces.
Yoshitaka Furuta, Zheng Zhou
doaj   +1 more source

Phosphatidylserine in atherosclerosis [PDF]

Current Opinion in Lipidology, 2016
Purpose of review It is now widely acknowledged that phosphatidylserine is a multifunctional bioactive lipid. In this review, we focus on the function of phosphatidylserine in modulating cholesterol metabolism, influencing inflammatory response and regulating coagulation system, and discuss promising phosphatidylserine-based ...
Darabi, Maryam, Kontush, Anatol
openaire   +4 more sources

Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

Biology Open, 2021
Phosphatidylethanolamine is an abundant component of most cellular membranes whose physical and chemical properties modulate multiple aspects of organelle membrane dynamics. An evolutionarily ancient mechanism for producing phosphatidylethanolamine is to
Santosh Kumar, Chandramohan Chitraju, Robert V. Farese, Tobias C. Walther, Christopher G. Burd   +4 more
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Circulating Microparticles in the Pathogenesis and Early Anticoagulation of Thrombosis in COVID-19 With Kidney Injury

Frontiers in Cell and Developmental Biology, 2022
As more is learned about the pathophysiological mechanisms of COVID-19, systemic thrombosis has been recognized as being associated with more severe clinical manifestations, mortality and sequelae.
Chengyue Wang, Chengyue Wang, Chengyuan Yu, Chengyuan Yu, Valerie A. Novakovic, Rujuan Xie, Jialan Shi, Jialan Shi, Jialan Shi   +8 more
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Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling

Cellular & Molecular Biology Letters, 2023
Background The dynamics of phosphatidylserine in the plasma membrane is a tightly regulated feature of eukaryotic cells. Phosphatidylserine (PS) is found preferentially in the inner leaflet of the plasma membrane.
Eimina Dirvelyte, Daina Bujanauskiene, Evelina Jankaityte, Neringa Daugelaviciene, Ugne Kisieliute, Igor Nagula, Rima Budvytyte, Urte Neniskyte   +7 more
doaj   +1 more source

Phosphatidylserine, a death knell [PDF]

Cell Death & Differentiation, 2001
Virtually every cell in the body restricts phosphatidylserine (PS) to the inner leaflet of the plasma membrane by energy-dependent transport from the outer to the inner leaflet of the bilayer. Apoptotic cells of all types rapidly randomize the asymmetric distribution, bringing PS to the surface where it serves as a signal for phagocytosis.
Patrick Williamson, Robert A. Schlegel
openaire   +3 more sources