Results 21 to 30 of about 114,304 (186)

Sensing Phosphatidylserine in Cellular Membranes

Sensors, 2011
Phosphatidylserine, a phospholipid with a negatively charged head-group, is an important constituent of eukaryotic cellular membranes. On the plasma membrane, rather than being evenly distributed, phosphatidylserine is found preferentially in the inner ...
Jason G. Kay, Sergio Grinstein
doaj   +1 more source

Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia

Frontiers in Neurology, 2021
Introduction: Hereditary spastic paraplegia is a clinically and genetically heterogeneous neurological entity that includes more than 80 disorders which share lower limb spasticity as a common feature.
Ashraf Yahia, Ashraf Yahia, Ashraf Yahia, Ashraf Yahia, Liena E. O. Elsayed, Liena E. O. Elsayed, Remi Valter, Remi Valter, Ahlam A. A. Hamed, Inaam N. Mohammed, Maha A. Elseed, Mustafa A. Salih, Typhaine Esteves, Typhaine Esteves, Nicolas Auger, Nicolas Auger, Rayan Abubaker, Mahmoud Koko, Fatima Abozar, Hiba Malik, Rawaa Adil, Sara Emad, Mhammed Alhassan Musallam, Razaz Idris, Isra Z. M. Eltazi, Arwa Babai, Elhami A. A. Ahmed, Amal S. I. Abd Allah, Mathilde Mairey, Ahmed K. M. A. Ahmed, Ahmed K. M. A. Ahmed, Ahmed K. M. A. Ahmed, Mustafa I. Elbashir, Alexis Brice, Muntaser E. Ibrahim, Ammar E. Ahmed, Foudil Lamari, Giovanni Stevanin, Giovanni Stevanin   +38 more
doaj   +1 more source

Circulating Microparticles in the Pathogenesis and Early Anticoagulation of Thrombosis in COVID-19 With Kidney Injury

Frontiers in Cell and Developmental Biology, 2022
As more is learned about the pathophysiological mechanisms of COVID-19, systemic thrombosis has been recognized as being associated with more severe clinical manifestations, mortality and sequelae.
Chengyue Wang, Chengyue Wang, Chengyuan Yu, Chengyuan Yu, Valerie A. Novakovic, Rujuan Xie, Jialan Shi, Jialan Shi, Jialan Shi   +8 more
doaj   +1 more source

7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]

, 2019
BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M., Attanzio A., Cilla A., Frazzitta A., Livrea M. A., Tesoriere L.   +5 more
core   +1 more source

Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells

Molecular Therapy: Methods & Clinical Development, 2023
Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV)-infected cells express phosphatidylserine (PS) early post infection.
Daniel Corey, Francoise Haeseleer, Joe Hou, Lawrence Corey   +3 more
doaj   +1 more source

Stabilin Receptors: Role as Phosphatidylserine Receptors

Biomolecules, 2019
Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes ...
Seung-Yoon Park, In-San Kim
doaj   +1 more source

Programmed cell death of platelets during their overactivation

Онкогематология, 2015
Programmed cell death – it is a cell death by a strictly defined mechanism with possible impact on him and, due to this, the death control, including using of pharmacological agents.
E. O. Artemenko, A. N. Sveshnikova, M. A. Panteleev   +2 more
doaj   +3 more sources

Influenza A matrix protein M1 induces lipid membrane deformation via protein multimerization [PDF]

, 2019
The matrix protein M1 of the Influenza A virus (IAV) is supposed to mediate viral assembly and budding at the plasma membrane (PM) of infected cells. In order for a new viral particle to form, the PM lipid bilayer has to bend into a vesicle toward the ...
Chiantia, Salvatore, Dahmani, Ismail, Ludwig, Kai   +2 more
core   +1 more source

Translocating the blood-brain barrier using electrostatics [PDF]

, 2012
Copyright © 2012 Ribeiro,Domingues, Freire,Santos and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the ...
Castanho, Miguel A. R. B., Domingues, Marco M., Freire, João M., Ribeiro, Marta M. B., Santos, Nuno C.   +4 more
core   +2 more sources

Vitamin C inhibits endothelial cell apoptosis in congestive heart failure [PDF]

, 2007
Background - Proinflammatory cytokines like tumor necrosis factor- and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced ...
Aicher, A, Dimmeler, S, Freyssinet, JM, Haase, A, Hoffmann, J, Hugel, B, Mallat, Z, Rossig, L, Tedgui, A, Zeiher, AM   +9 more
core   +1 more source