Untargeted Lipidomic Analysis to Broadly Characterize the Effects of Pathogenic and Non-Pathogenic Staphylococci on Mammalian Lipids [PDF]
, 2018 Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the ...
Baker, Paul RS +5 more
core +4 more sources
Interaction between Phosphatidylserine and the Phosphatidylserine Receptor Inhibits Immune Responses In Vivo [PDF]
The Journal of Immunology, 2005 AbstractPhosphatidylserine (PS) on apoptotic cells promotes their uptake and induces anti-inflammatory responses in phagocytes, including TGF-β release. Little is known regarding the effects of PS on adaptive immune responses. We therefore investigated the effects of PS-containing liposomes on immune responses in mice in vivo. PS liposomes specifically
David L. Daleke +8 more
openaire +3 more sources
altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]
, 2018 The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel +3 more
core +1 more source
Membrane Binding and Bending in Ebola VP40 Assembly and Egress
Frontiers in Microbiology, 2014 Lipid-enveloped viruses contain a lipid bilayer coat that protects their genome and helps to facilitate entry into the host cell. Filoviruses are lipid-enveloped viruses that have up to 90% clinical fatality and include Marbug (MARV) and Ebola (EBOV ...
Robert V Stahelin, Robert V Stahelin
doaj +1 more source
Frontiers in Neurology, 2021 Introduction: Hereditary spastic paraplegia is a clinically and genetically heterogeneous neurological entity that includes more than 80 disorders which share lower limb spasticity as a common feature.
Ashraf Yahia +38 more
doaj +1 more source
Phosphatidylserine hide-and-seek [PDF]
Proceedings of the National Academy of Sciences, 2018 Every day, billions of new cells are produced in our bodies, and an equivalent number must die. Normally this occurs by apoptosis (1), during which the chromatin compacts against the nuclear envelope, followed rapidly by nuclear fragmentation and budding into multiple membrane-bound apoptotic bodies. This “dance of death” results from the activation of
openaire +3 more sources
7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]
, 2019 BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M. +5 more
core +1 more source
Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis. [PDF]
, 2016 Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic ...
Feldstein, Ariel E, Povero, Davide
core +2 more sources
Translocating the blood-brain barrier using electrostatics [PDF]
, 2012 Copyright © 2012 Ribeiro,Domingues, Freire,Santos and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the ...
Castanho, Miguel A. R. B. +4 more
core +2 more sources
Stimulation of Erythrocyte Cell Membrane Scrambling by Mushroom Tyrosinase
Toxins, 2014 Background: Mushroom tyrosinase, a copper containing enzyme, modifies growth and survival of tumor cells. Mushroom tyrosinase may foster apoptosis, an effect in part due to interference with mitochondrial function.
Leonie Frauenfeld +3 more
doaj +1 more source