Results 11 to 20 of about 9,975 (285)

Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease

Metabolites, 2022
(1) Background: This work aims to investigate the metabolomic changes in PIGinH11 pigs and investigate differential compounds as potential therapeutic targets for metabolic diseases.
Jianping Xu, Kaiyi Zhang, Bintao Qiu, Jieying Liu, Xiaoyu Liu, Shulin Yang, Xinhua Xiao   +6 more
doaj   +1 more source

Plasma procoagulant phospholipid clotting time and venous thromboembolism risk

Research and Practice in Thrombosis and Haemostasis, 2021
Background Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles.
Cathrine Ramberg, Line Wilsgård, Nadezhda Latysheva, Sigrid K. Brækkan, Kristian Hindberg, Timofey Sovershaev, Omri Snir, John‐Bjarne Hansen   +7 more
doaj   +1 more source

Fumonisin B Series Mycotoxins’ Dose Dependent Effects on the Porcine Hepatic and Pulmonary Phospholipidome

Toxins, 2022
Male weaned piglets n = 6/group were fed Fumonisin B1+2+3 (FBs) mycotoxins at 0, 15, or 30 mg/kg diet for 3 weeks to assess the fatty acid (FA) composition of membrane lipid classes, lipid peroxidation, and histomorphological changes in the liver and ...
Omeralfaroug Ali, Miklós Mézes, Krisztián Balogh, Melinda Kovács, Janka Turbók, András Szabó   +5 more
doaj   +1 more source

Worms, Fat, and Death: Caenorhabditis elegans Lipid Metabolites Regulate Cell Death

Metabolites, 2021
Caenorhabditis elegans is well-known as the model organism used to elucidate the genetic pathways underlying the first described form of regulated cell death, apoptosis. Since then, C.
Marcos A. Perez, Jennifer L. Watts
doaj   +1 more source

Lipidomic Assessment of Plasma and Placenta of Women with Early-Onset Preeclampsia [PDF]

, 2014
Introduction: Adipose tissue is responsible for triggering chronic systemic inflammatory response and these changes may be involved in the pathophysiology of preeclampsia.
Bonetti, Tatiana, Cerdeira, Ana Sofia, Câmara, Niels Olsen S., Da Silva, Ismael Dale Cotrim Guerreiro, De Oliveira, Leandro, Korkes, Henri Augusto, Moron, Antonio F., Sass, Nelson   +7 more
core   +8 more sources

Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)

Scientific Reports, 2022
Evidence is mounting that the nature of the lipid bound to the endothelial cell protein C receptor (EPCR) has an impact on its biological roles, as observed in anticoagulation and more recently, in autoimmune disease.
Elena Erausquin, María Morán-Garrido, Jorge Sáiz, Coral Barbas, Gilda Dichiara-Rodríguez, Alejandro Urdiciain, Jacinto López-Sagaseta   +6 more
doaj   +1 more source

Effects of Natural Antioxidants on Phospholipid and Ceramide Profiles of 3D-Cultured Skin Fibroblasts Exposed to UVA or UVB Radiation

Antioxidants, 2021
Ultraviolet (UV) radiation is one of the primary factors responsible for disturbances in human skin cells phospholipid metabolism. Natural compounds that are commonly used to protect skin, due to their lipophilic or hydrophilic nature, show only a narrow
Agnieszka Gęgotek, Wojciech Łuczaj, Elżbieta Skrzydlewska   +2 more
doaj   +1 more source

A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife [PDF]

, 2016
Background: This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas. Methods: Patients undergoing elective surgical resection for CRC were recruited at St.
Alexander, J, Balog, J, Darzi, A, Gildea, L, Goldin, R, Hoare, J, Kinross, J, Kontovounisios, C, McKenzie, J, Muirhead, L, Nicholson, J, Rasheed, S, Scott, A, Speller, A, Takats, Z, Teare, J, Tekkis, P, Veselkov, K   +17 more
core   +1 more source

Untargeted Lipidomics and Chemometric Tools for the Characterization and Discrimination of Irradiated Camembert Cheese Analyzed by UHPLC-Q-Orbitrap-MS

Foods, 2023
In this work, an investigation using UHPLC-Q-Orbitrap-MS and multivariate statistics was conducted to obtain the lipid fingerprint of Camembert cheese and to explore its correlated variation with respect to X-ray irradiation treatment.
Michele Tomaiuolo, Valeria Nardelli, Annalisa Mentana, Maria Campaniello, Rosalia Zianni, Marco Iammarino   +5 more
doaj   +1 more source

Tacrine and its analogues impair mitochondrial function and bioenergetics : a lipidomic analysis in rat brain [PDF]

, 2012
Tacrine is an acetylcholinesterase inhibitor used as cognitive enhancer in Alzheimer's disease treatment. However, the low therapeutic efficiency and the high incidence of side effects have limited its clinical use.
Antunes-Madeira, Bartlett, Battino, Berson, Bligh, Brügger, Chicco, Drukarch, Ellman, Fang, Fry, Galisteo, Gornall, Hallivel, Han, Heilbronn, Hsu, Hsu, Kagan, Kiebish, Kiebish, Kiebish, Kozurkova, Lehtonen, Maciel, Madeira, Mansouri, Masson, Meng, Monteiro, Osseni, Petrosillo, Pfeiffer, Pope, Proctor, Pulfer, Salaheldin, Schlame, Selkoe, Sergent, Smith, Spaldin, Talesa, Terry, Tyurin, Tyurina, Vilela, Wallace, Wallace, Walsh, Watkins   +50 more
core   +1 more source