Results 71 to 80 of about 52,049 (355)

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Advanced phosphocreatine-grafted chitosan hydrogel promote wound healing by macrophage modulation

Frontiers in Bioengineering and Biotechnology, 2023
Background: The repair of wounds usually caused by trauma or other chronic diseases remained challenging in clinics due to the potential risk of inflammation and inadequate tissue regenerative properties.
Weibei Sheng, Haotian Qin, Tiehua Wang, Jin Zhao, Chongzhou Fang, Peng Zhang, Peng Liu, Anjaneyulu Udduttula, Hui Zeng, Yingqi Chen   +9 more
doaj   +1 more source

General features of the retinal connectome determine the computation of motion anticipation [PDF]

, 2015
Motion anticipation allows the visual system to compensate for the slow speed of phototransduction so that a moving object can be accurately located.
Asari, Baylor, Berry, Bischofberger, Blitz, Bollmann, Bonin, Borst, Branco, Branco, Briggman, Bölinger, Cafaro, Calkins, Calkins, Chen, Demb, Dreosti, Esposti, Freed, Gleeson, Gollisch, Goodale, Gouras, Haider, Hao, Hausselt, Haverkamp, Helmstaedter, Hines, Hitchcock, HUBEL, Isaacson, Jakobs, Jarsky, Johnston, Koch, Koizumi, Kolb, Kolb, Kolb, Koontz, Kuzmiski, Lee, Leonardo, Levick, Liu, London, Lukasiewicz, MacNeil, Magee, Malpeli, Manookin, Marshak, Marshak, Masland, Miller, Münch, Nikolaev, Odermatt, Oesch, Olveczky, Owczarzak, Pouille, Quiroga, RALL, Rieke, Roska, Schachter, Schwartz, Schwartz, Sivyer, Smith, Talbot, Tanaka, Taylor, Trenholm, Weber, West, Xu, Yonehara, Zhu   +81 more
core   +2 more sources

ZSF1 lean rats – How healthy are they?

Animal Models and Experimental Medicine, EarlyView.
This study aimed to examine the health status, specifically the physiology and myocardial, vascular, and skeletal muscle function of lean ZSF1 rats by comparing them to age‐ and sex‐matched Wistar rats. Compared to Wistar controls, ZSF1 lean rats exhibited lower body weight, but showed increased heart, and skeletal muscle mass.
Antje Schauer, Beatrice Vahle, Volker Adams, Axel Linke, Antje Augstein   +4 more
wiley   +1 more source

The effect of high carbohydrate meals with different glycemic indices on recovery of performance during prolonged intermittent high intensity shuttle running [PDF]

, 2006
This study examined the effect of high carbohydrate meals with different glycemic indices (GI) on recovery of performance during prolonged intermittent high-intensity shuttle running.
Chamberlain, Siobhan, Crews, Pippa, Erith, Samuel, Rushbury, Ian, Stevenson, Emma, Williams, Clyde   +5 more
core   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

IRES-mediated Pichia pastoris cell-free protein synthesis

Bioresources and Bioprocessing, 2023
Cell-free protein synthesis (CFPS) system is an ideal platform for fast and convenient protein research and has been used for macromolecular assembly, unnatural amino acid embedding, glycoprotein production, and more.
Yanan Wang, Ting Wang, Xinjie Chen, Yuan Lu   +3 more
doaj   +1 more source

Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease [PDF]

, 2009
Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lifethreatening cerebral oedema and dysmyelination in affected individuals.
Ara  jo, Ba  os, Cremer, Crome, Daniel, Dhopeshwarkar, Dodd, G. E. Homanics, H. S. Paul, Hariharan, Hauber, Homanics, J. Lazovic, J. M. Flanagan, Jan, K. C. Cheng, K. F. LaNoue, K. Griffin, K. J. Skvorak, Kamei, Killian, Le Masurier, Lowry, Lo  , M. C. Bewley, Mackenzie, McKean, Morton, O'Callaghan, Ouary, Patel, Patel, Regunathan, Schadewaldt, Schmithorst, Schonberger, Sgaravatti, She, SILBERMAN, Simon, Tews, W. J. Zinnanti, Wajner, Williamson, Yudkoff   +44 more
core   +2 more sources

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low‐Normal Ankle‐Brachial Index

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundLower muscle mitochondrial energy production may contribute to impaired walking endurance in patients with peripheral arterial disease. A borderline ankle‐brachial index (ABI) of 0.91 to 1.10 is associated with poorer walking endurance compared
Majd AlGhatrif, Ariel Zane, Matt Oberdier, Marco Canepa, Stephanie Studenski, Eleanor Simonsick, Richard G. Spencer, Kenneth Fishbein, David Reiter, Edward G. Lakatta, Mary M. McDermott, Luigi Ferrucci   +11 more
doaj   +1 more source